Familial malignant atrophic papulosis (Degos' disease)--additional evidence for heredity and a benign course.
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Biomedical subjects
Publications and source records attributed to L S Kisch.
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Three patients had hereditary multiple trichodiscomas of early onset and dominant inheritance. This report is an analysis of the histologic, histochemical, immunohistochemical, and electron microscopic findings in 27 trichodiscomas, the largest published series so far, to our knowledge. The tumors of perifollicular connective tissue are briefly reviewed and a classification is proposed. Hereditary multiple trichodiscomas are regarded as a new entity that should be distinguished from the syndrome recently described by Birt and associates that is characterized by autosomal dominant inherited fibrofolliculomas as the hallmark, associated with trichodiscomas and acrochordons.
A family is described in which a mother and five of her children were affected by malignant atrophic papulosis. This suggests that genetic factors might be involved in this condition.
Four patients engaged on a medium-sized engineering factory were investigated because of hand dermatitis by contact with cooling oils. Two patients showed allergy to formaldehyde. After eliminating all Grotans the two patients with allergy to formaldehyde became free of dermatitis. However no evidence of allergy could be found for the two Grotans which are formaldehyde releasers. In the literature there is a remarkable confusion about the sensitizing capacity of especially Grotan BK. Wet emulsions and finished oil might be important in explaining causative factors in occupational dermatitis of metal workers.