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Biomedical subjects

L S Ko

Publications and source records attributed to L S Ko.

At least 19 recordsLinked to original sources
PubMed1991

Ocular fundus examination in premature infants.

In order to better acknowledge the ocular fundus picture in premature infants and to determine the incidence and clinical course of retinopathy of prematurity (ROP), from October 1987 to April 1989, 187 cases with a gestational age of less than 38 weeks or a birth weight of less than 2,500 g were enrolled for examination and follow-up study with indirect ophthalmoscope. One hundred and fifty cases (80.21%) were free from ROP bilaterally. Thirty-seven cases (19.79%) had ROP. Except for one case that showed unilateral regressed ROP, all were bilaterally affected. The mean birth weight and gestational age in the nonROP group were 1,824 +/- 426 g and 33.6 +/- 2.9 weeks, respectively, and in the ROP group were 1,395 +/- 490 g and 30.7 +/- 3.9 weeks, respectively. The difference for both factors between the two groups were statistically significant (p less than 0.05). Several specific fundus features were noticed in a high percentage of the nonROP group, these included a small cup to disc (C/D) ratio, pigmented ring around the disc, hypopigmented fundus and a greenish-gray color in the peripheral vascularized retina. In addition, 8.2% of this group had persistent primary vitreous remnant, and 5.6% had retinal hemorrhage. The macular development was subdivided into three stages. In both the ROP and nonROP groups, the difference of gestational age at each advancing stage was statistically significant by the Student t-test. No delay in macular development was noticed in the ROP group.(ABSTRACT TRUNCATED AT 250 WORDS)

Follow-Up Studies↗
PubMed1990

Embedded hard contact lens: reports of a case.

Contact lens migration into the upper eye lid with resultant lid mass is a rare complication of hard contact lens wear. We present a case in which a cosmetically unacceptable upper lid mass was the chief problem. The patient had switched to soft contact lenses and tolerated them well for about 13 months. From computed tomographic scan pictures and the keratoscopic change, surgical exploration through the opening of a discharging sinus in the upper forniceal area delivered a 8 x 8 mm hard contact lens and a flux of tenacious mucoid discharge. Double eversion of the upper tarsus, which was advised by Green in 1963, was the most important technique in reaching the correct diagnosis, and it should be stressed again on examining patients with a history of displaced hard contact lens.

Adult↗
PubMed1989

Clinical observations on occlusion myopia.

The authors studied the refractive errors and axial lengths on thirty patients. A retrospective analysis suggests some degree of monocular vision deprivation early in life. Axial myopia was found in most of the cases, indicating that emmetropization is a vision-dependent phenomenon. But, some exceptions were found, supporting the concept that multiple factors are involved in the pathogenesis of myopia.

Adolescent↗
PubMed1989

[Tear lactoferrin in keratoconjunctivitis sicca].

Keratoconjunctivitis sicca is a commonly encountered disease with decreased lacrimal gland activity. There are several tests to determine the lacrimal gland function, but all have limitations in accuracy, sensitivity or technical difficulty. At present, there is no reliable objective test to render a firm diagnosis of dry eye. Lactoferrin is one of the major proteins secreted by the lacrimal gland. Its concentration was found to correlate well to lacrimal gland activity. In this study we tried to evaluate the diagnostic value of lactoferrin measurement in comparison with other tests for keratoconjunctivitis sicca. Tests including the measurement of tear lactoferrin, Schirmer's-1 test, Schirmer's basal test, tear film break-up time, and rose bengal stain of the cornea were done on 60 healthy eyes and 56 eyes with keratoconjunctivitis sicca. The lactoferrin level was measured by a commercially available "Lactoplate" (Eagle Vision, U.S.A.). It is a plate containing gel loaded with rabbit anti-human-lactoferrin antiserum. Tear-moistened filter paper discs containing lactoferrin were placed on the gel. The lactoferrin concentration could be determined by measuring the concentric ring of precipitate after 72 hours incubation at room temperature. The average concentration of lactoferrin was 1.9 +/- 0.51 mg/ml in the normal group and 1.4 +/- 0.93 mg/ml in the keratoconjunctivitis sicca group. They were significantly different from each other (t-test: p less than 0.05). The results of the other 4 tests also showed a significant difference between the normal and keratoconjunctivitis sicca group, but the lactoferrin measurement had the highest specificity among these 5 tests. Because of the technical simplicity of measurement and its high specificity, lactoferrin measurement could be a valuable tool for the early and accurate diagnosis of keratoconjunctivitis sicca.

Adult↗
PubMed1988

Correlation of optical components with ocular refraction among teen-agers in Taipei.

From 2 senior-high and 2 vocational schools in Taipei, 3251 children with age 16-19 were randomly selected to study the relationship between ocular refraction and its main optical components, corneal curvature and axial length. While the corneal curvature was found to play only a minor role in the determination of ocular refraction, the measurements of axial length parallelled the degree of myopia (r = 0.74). A two-years' longitudinal study of additional 411 children from one junior-high school (age 13 through 15) further pointed to the importance of axial length in the production and progression of myopia.

Adolescent↗