[Temporary occlusion of the bronchi in the combined treatment of pyopneumothorax].
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Biomedical subjects
Publications and source records attributed to L S Lesnitskiĭ.
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The appearance of suppuration of the operation wound is real after resection of lungs for a restricted and spread gangrene despite prophylactic use of antibiotics and washing of the wound with antiseptics. Early diagnosis of local suppuration of the wound, effective drainage of the focus and increase of non-specific resistance give a way out of the situation. Choice of diagnostic criteria of suppuration and a method of correction of healing the thoracotomic wound are presented.
A simple, effective and safe method is proposed to liquidate a persistent residual pleural cavity by a biological filling prepared ex tempore from a solution of fibrinogen with antibacterial drugs. The method was used in 24 patients after pleura empyema. The method of filling is described as well as the conditions for a successful use of the new means of liquidation of the residual pleural cavity and prevention of recurrent pleura empyemas.
On the basis of the experience with the treatment of 69 patients with lung gangrene the authors recommend to use a combination of active aspiration from the pleural cavity, occlusion of the segment bronchus and pneumoperitoneum for the efficient expansion of the lung after its resection in the early postoperative period.
The dependence of the activity of lysosomal enzymes upon the degree of the pyo-destructive process and the character of the course of the postoperative period has been established on the basis of studying the activity of lysosomal enzymes of leukocytes of blood and pleural exudate, titre of natural and heterophyllic antibodies, components of the kallikrein-kinin system in pyo-destructive diseases of the lungs and pleura. Pathogenetically substantiated ways of prevention of postoperative infectious complications are proposed.
In experiments in rabbits the authors have elaborated safe (in relation to a barotrauma of the lungs) regimens of the pressure changes taking place while performing HBO. In the treatment of 127 patients with acute suppurations of the lungs and pleura it was established that a short course of HBO (4-5 sessions) in the regimens used was safe and clinically effective. The method is recommended for the treatment of patients with spreaded injuries of the pulmonary tissue developing with a pronounced endogenous intoxication.
The osmolar status was studied in 63 patients with acute abscesses of lungs and empyema of pleura at different stages of the conservative and operative treatment. The hypoosmolarity syndrome was revealed at the acute stage of the disease against the background of a pronounced purulent intoxication. An increased excretion of nonidentified osmotically active metabolites with urine was registered at the height of pyodestructive process and postoperative disease.
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On the basis of experimental and laboratory investigations high fibrinolytic effect of the home proteolytic enzyme terrilythin and the absence of general toxic reactions after intrapleural administration of the drug have been proved. The article describes results of clinical results of clinical tests of the effectiveness of terrilythin in coagulated hemothorax after traumas of the chest and operations on the lungs and in 55 patients with acute pro-fibrinous pleurisy. The successful preventive sanitation was performed in 43 of 50 patients with coagulated hemothorax and initial symptoms of the infectious process as well at the development of pleural empyema were averted.
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Eleven patients with metastatic acute purulent-destructuve processes in the lungs and pleura in sepsis were operated on. Fifteen operations were performed: 3 lobectomy, 1 pneumonectomy, 8 drainages of the pleural cavity with its sanitation, 1 drainage of a pulmonary abscess with thoracocentesis and 1 thoracotomy. Sepsis was treated by complex methods. Nine patients were discharged in a good condition. Two patients died.
Experimentally it has been shown that diluted Pervomur (1:3) may be used for the intraoperation washing of the pleural cavity. The use of the diluted drug during the operations for acute purulent diseases of the lungs and pleura made it possible to prevent postoperative pleural empyemas and suppluration of soft tissue wounds in most patients.
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