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Biomedical subjects

L S Matveeva

Publications and source records attributed to L S Matveeva.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

[The nature of the pancreatic hormone secretion and of the metabolic indices during the acute and chronic administration of peroral hypoglycemic preparations].

A comparative study of the effect of acute and chronic administration of sulfanilureal sugar lowering drugs (glipizide and glibenclamide) on the secretion of the pancreatic hormones, indices of microcirculation, the level of triglycerides and nonesterified fatty acids was conducted. Patients with primary detected diabetes mellitus with normal body mass and obesity of I-III degrees were investigated. The principal differences in insulinotropic action of sugar lowering drugs in various groups of patients and significant differences in the mechanism of their hypoglycemic action at varying time of treatment indicate the necessity of a strictly differentiated approach to subscription of these drugs for patients with primary detected diabetes mellitus.

Adult↗
PubMedDate not supplied

[Effect of thyroliberin on the prolactin level in the blood serum of primary hypothyroid patients].

Results of study of the basic prolactin level and its response to the stimulating action of exogenous thyroliberin in 23 women with primary hypothyroidism are presented; alteration of prolactin secretion in these patients under the effect of replacement thyroid hormone therapy is shown. In the majority of patients with primary hypothyroidism prolactin level was elevated in comparison with the normal, and its secretion in response to TRH was considerably increased. There were no significant differences in the basic prolactin level and in its response to TRG in patients with primary hypothyroidism with or without lactorrhea, and with lactorrheaamenorrhea. Lactorrhea can develop in the patients with increased or with normal blood serum prolactin level. Sensitivity of thyrotrophs and lactotrophs to the inhibitory action of thyroid hormones proved to differ. The efficacy of replacement therapy in patients with primary hypothyroidism combined with lactorrhea-amenorrhea, leading to restoration of the patients' fertility, was demonstrated.

Adult↗