PubMed Health⌕ Search

Biomedical subjects

L S Valberg

Publications and source records attributed to L S Valberg.

95 records · Page 6Linked to original sources

The mechanism of plasma albumin loss in carcinoma of the cecum.

Investigation of hypoalbuminemia in an elderly woman with a large papillary adenocarcinoma of the cecum revealed that the hypoproteinemia was due to excessive loss of plasma albumin into the intestinal tract. Results of studies on this patient and analysis of published reports suggest that several factors were involved in the loss of albumin from the neoplasm, namely, the size and location of the tumour, absence of normal surface epithelium, presence of exudate on the surface of the tumour due to tumour necrosis and secondary infection, and bleeding from damaged vessels near the surface of the tumour.

Adenocarcinoma↗

Gastrointestinal absorption and organ distribution of oral cadmium chloride and cadmium-metallothionein in mice.

Body retention and tissue distribution of Cd from oral 109CdCl2 and 109Cd-metallothionein were studied in C57BL/6J mice given identical doses (60 microgram Cd and 2 muCi 109Cd). Measurement of 109Cd radioactivity in mice showed identical absorption but differences in tissue distribution of Cd from the two forms. A significantly greater deposition of Cd was observed in the kidney of mice fed Cd-metallothionein than in the CdCl2 group where a major portion of Cd was deposited in the liver. Most of the radioactive Cd in the renal and hepatic tissue and in the duodenum was bound to metallothionein 24 h after oral Cd-metallothionein, whereas only 30 and 38% of the cadmium in liver and kidney supernatants, respectively, were bound to metallothionein after oral CdCl2. These results suggest that the dietary form of Cd may influence the renal deposition of Cd.

Animals↗