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Biomedical subjects

L SOKOLOFF

Publications and source records attributed to L SOKOLOFF.

At least 19 recordsLinked to original sources
PubMed1963

ELASTICITY OF ARTICULAR CARTILAGE: EFFECT OF IONS AND VISCOUS SOLUTIONS.

The deformability of articular cartilage is increased by cations, more so by polyvalent than monovalent ones. Trivalent cations also depress elastic recovery. Failure of viscous solutions to alter the elastic behavior suggests ultra-filtration by cartilage as a possible mechanism in synovial lubrication.

Ammonium Chloride↗
PubMed1963

Thyroxine: effects on amino acid incorporation into protein in vivo.

Treatment of rats with L-thyroxine increases the incorporation in vivo of radioactive amino acids into protein of liver, kidney, and heart, but not of spleen, testis, or brain. The distribution of the effect among the organs is the same as that observed in thyroxine stimulation of oxidative metabolism. Thus, stimulation of protein synthesis seems to be a physiological action of the thyroid hormone.

Amino Acids↗
PubMed1963

Reversal of thyroxine-induced hypermetabolism by puromycin.

Previous studies have demonstrated that in addition to its effects on metabolic rate, thyroxine stimulates protein biosynthesis. The administration of puromycin, a drug which blocks protein synthesis and, therefore, the thyroxine effect on protein synthesis, acutely reverses the hypermetabolism induced in rats by prior administration of thyroxine and restores the oxygen consumption of the thyrotoxic rats to the euthyroid level. The results suggest that a larger fraction of the total body basal oxygen consumption in hyperthyroidism is related to the process of protein synthesis than in the euthyroid state and that the calorigenic effect of thyroxine is secondary to its effect on protein synthesis.

Animals↗