FACILITATION OF AVOIDANCE BEHAVIOR BY POSITIVE BRAIN STIMULATION.
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Biomedical subjects
Publications and source records attributed to L STEIN.
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Atropine and scopolamine were compared with their centrally inactive quaternary analogs, atropine methyl nitrate and scopolamine methyl nitrate, for effects on water and food intake in rats. All drugs inhibited eating, but only the centrally active compounds inhibited drinking. Anticholinergic drugs evidently block drinking by a central effect and eating by a peripheral effect.
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A modification of the self-stimulation technique of Olds enabled rats to regulate and maintain at a preferred level the amount of brain-stimulating current they received as reinforcement for lever pressing. The method used two levers to deliver brief brain shocks: each response at one lever increased the current intensity a small step and each response at the other lowered it one step.
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