[Action of chlordiazepoxide (Napoton) on the behavior of mice after its administration in association with chlorpromazine, imipramine and nialamide].
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to L Safta.
Explore the source record for details and available documents.
The duration of the analgesic effect of levomepromazine was prolonged in mice when associated with propranolol. The administration of morphine to animals treated with propranolol resulted in an increase of morphine toxicity with death of some animals.
Explore the source record for details and available documents.
The i.v. administration of amphepramone in dogs induced a dose-related depressor reaction. This effect was due to a peripheral myotropic vasodilatation. When the drug was administered intracerebroventricularly it elicited a marked pressor response, due, to the release of catecholamines with its subsequent action on alpha-adrenergic receptors. Small doses of amphepramone administered in dogs, rats and rabbits, induced a sinus tachycardia. Larger doses brought about a sinus bradycardia, bradyarrhythmias, extrasystoles, ventricular bradycardia and ventricular fibrillation or asystolia. The respiratory movements as well as the EEG tracings were depressed by larger doses of amphepramone.