Biomedical subjects

L Sandles

Publications and source records attributed to L Sandles.

3 recordsLinked to original sources

PubMed1989

Outcome from multiple joint replacement surgery to the lower limbs.

All patients who had three or more major joints (hips or knees) replaced were identified from operation records at one hospital and reviewed to assess outcome. Forty-three were found to suffer from rheumatoid arthritis, four from osteoarthritis and three from psoriatic arthritis. Eight patients had died an average of 2.6 years (range 1-7 years) after their last operation and this was higher than expected, even for RA. Average follow-up in the 36 surviving RA sufferers was 1.8 years, with a minimum of 6 months since last operation. Range of joint movement, pain relief, satisfaction, mobility, disability and social outcomes were assessed and are reported. Patients were satisfied with outcome because of pain relief and functional improvement. No patient required permanent in-patient care, although they still represented a very disabled group with mean HAQ score of 2.75.

Aged↗

PubMed1983

APUD system neoplasms in renal transplant patients.

Apudomas are uncommon neoplasms composed of neuroendocrine cells. They include carcinoid tumors, islet cell tumors, and small cell lung carcinoma. We found six cases of apudomas in a series of 1028 renal transplants from three medical centers (0.58%). One of these had been reported in 1976. The cases included a carcinoid tumor of a Meckel's diverticulum discovered and removed prior to transplantation, with no evidence of recurrence 9 years later. A small cell lung carcinoma was discovered 40 months after renal transplantation, with a fatal outcome 6 months later. Four clinically occult apudomas were found at autopsy, including one gastric and one bronchial carcinoid tumor, one multicentric pancreatic islet cell neoplasm, and one case of multiple ileal carcinoids. With the exception of the small cell lung cancer, none of the apudomas was clinically significant, and none was associated with carcinoid or other paraneoplastic syndrome. These cases illustrate the difficulty of diagnosis of apudomas in patients with renal failure and the usually benign nature of these tumors despite the administration of potent immunosuppressive agents.

Adenoma↗

PubMed1977

Patterns of astroglial hypertrophy and neuronal degeneration in the hippocampus of ages, memory-deficient rats.

The brains of aged and young Fischer rats were examined using a modified version of Cajal's gold chloride stain for astrocytes. A sizable loss of pyramidal cells and remarkably hypertrophic astrocytes were found in the hippocampus of the aged animals, while the astrocytic changes were not seen in other forebrain regions. Four major characteristics of the pattern of hippocampal astrogliosis were noted: (1) the astrocytes were often found to be grouped in clusters; (2) grouped astrocytes were commonly seen to have similarly oriented processes; (3) small blood vessels were more often stained in regions of pyramidal cell degeneration and astroglial hypertrophy; and (4) reactive astrocytes were in several instances found to be gathered on the "border" between deteriorated regions and healthier appearing areas. This pattern was interpreted to suggest that the astrocyte clusters may be analogous to senile plaques. Since the aged Fischer animals have previously been found to exhibit retention deficits, the possibility that the hippocampal pathology is related to impaired memory in these animals was raised.

Animals↗