Among the various strategies proposed for the therapy of the luteal phase defects (L.P.D.), the administration of clomiphene citrate during the early follicular phase has proved to be very effective even though it is not one of the most used. Nevertheless, very soon has been risen the question if such drug acts by an overphysiological increase of the hormonal levels or instead by a re-balance of the altered latter ones. In order to answer this question a clinical study was carried out during 265 cycles on 63 normally ovulating and menstruating women, whose 27 with a luteal phase defect (L.P.D.), detected by clinical, echographic, endocrine, and morphological criteria. Each of these latter patients were given clomiphene citrate, 100 mg per day from the 2nd to the 6th day of the cycle, for a total of 108 cycles. The other 36 women without any luteal abnormality, were used during 156 cycles, as a control group. At the end of our study there were no significant differences in all parameters between two studied groups. This suggest that early follicular phase administration of clomiphene citrate in these pathologies can act by gradually improving the luteal function.

Clomiphene↗

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CA-125 and ovarian hyperstimulation.

The ovarian hyperstimulation syndrome (OHSS) has become more and more frequent in relation to the spread of the method of superovulation by means of pharmacologic induction and consequently the necessity of measures suitable for preventing and controlling it has been more and more improved. Among them the discovery of indicators which could reveal as early and sensitive as possible the onset and, when it is possible, also the degree of severity of this syndrome, holds an important position. Till now only the serum estradiol concentration performed this task, among the other things, in an incomplete and not-well defined manner, but its inadequacy has stimulated once again the search for new substances which would allow attention to be drawn to the development, entity and evolution of this syndrome in compliance with necessary requisites with greater timeliness, and tenacity. Therefore the behaviour of the serum CA-125 levels has been evaluated for the first time in 31 cycles of 31 patients, which were stimulated by gonadotropins (FSH, FSH/LH, HCG), of which 21 underwent ovarian hyperstimulation of various degree (10 of I, 8 of II and 3 of III grade), while the other 10 had no complications. The blood levels of this marker rose above the limit considered physiological (35 UI/ml) during the luteal phase in all the stimulated cycles and, in hyperstimulated ones always exceeded 70 UI/ml; in addition the serum CA-125 levels correlated very well with ovarian dimensions, degree of severity of the syndrome and estrogenic concentrations during only luteal phase, in the hyperstimulated cycles and continued to remain high or even increased in case of pregnancy.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

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Efficacy of biochemical vs biological monitoring during the "timing" of the chorionic gonadotropin administration in FSH and HMG stimulated cycles.

The problem of an exact timing of the HCG administration in stimulated cycles (for infertility problems) is of primary importance for optimizing the results. In this study the authors show the results obtained in two groups of patients to whom HCG was administered according to two different methods of monitoring: the first biochemical, the second biological. The examination of the results has proven that the insertion of the biological method (cervical mucus) among those used in the monitoring has allowed a significant increase of the biological response to treatment.

Adult↗

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Prophylaxis of anaerobic infections in obstetric surgery with injectable metronidazole.

Explore the source record for details and available documents.

Administration, Oral↗

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Lag in endometrial morphology in artificially reproduced cycles (ARC).

To observe if endometrial artificially reproduced cycles were identical to the natural spontaneous ones, we have matched for the endometria of 22 assessed spontaneous ovulating women and 16 postmenopausal ones sequentially treated with exogenous ovarian steroid hormones. The endometrial samples were drawn in the middle luteal phase (20th-22nd of an ideal cycle, 6-8 days from ultrasound assessed ovulation or progesterone exposure), because this is the "implantation window" period. These results can be particularly interesting in the FIV-OD technique that implyes the implantation of the zygote in a fully matured endometrium. Adversely to previous reports there was always an endometrial hystologic lag (2 min.-4 max. days) in all the artificially reproduced cycles observed, while no other endometrial anomalies were found in these last ones. Probably the contrasting results of the previous studies agree with the later timing of endometrial biopsy, because in the late luteal artificially reproduced or spontaneous endometrium there is no hystological difference.

Adult↗

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LUF-syndrome biological diagnosis by basal body temperature (BBT) graph.

73 consecutive patients were monitored and submitted to ambulatorial screening for primary infertility. In all of them was also performed a study of the BBT behaviour and the results reported on a graph. All these with LUF syndrome had substantial deviation of the BBT graphs. This observation can make us obtain a new parameter and a first diagnostic approach in the study of the ovulatory infertility.

Basal Metabolism↗

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CA-125 and uterine leiomyomas.

CA-125, in the past considered as marker of ovarian neoplasms, has been proven to be useful successively in several obstetric-gynecologic physiopathologic conditions (Endometriosis, beginning pregnancy, PID), united by the common characteristic of peritoneal involvement. Such evidence has suggested us to search possible correlations with uterine leiomyomatosis disease, which for its frequency has the character of a social disease. Our findings would justify the clinical use of this marker in the first screening of fibromiomas, but above all, its diagnostic utility in evolutive aspects of such pathology.

Adult↗