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Biomedical subjects

L Schirmer

Publications and source records attributed to L Schirmer.

8 recordsLinked to original sources
PubMed2005

Neuropsychological function in high-risk breast cancer survivors after stem-cell supported high-dose therapy versus standard-dose chemotherapy: evaluation of long-term treatment effects.

BACKGROUND: Studies on cognitive functioning in breast cancer patients point out that a subset of women exhibit chemotherapy-related neuropsychological impairment. Thereby, high-dose therapy may elevate the risk of cognitive dysfunctions. The primary purpose of the study was to evaluate the impact of high-dose versus standard-dose chemotherapy on the late neuropsychological outcome in randomized assigned high-risk breast cancer survivors. Next to focusing prevalence, function specificity and extent of cognitive impairment, the question as to whether doses-dependent group differences occur was investigated. PATIENTS AND METHODS: Twenty-four high-dose and 23 standard-dose patients 5 years, on average, after treatment underwent a comprehensive neuropsychological assessment. In addition, 29 early-stage breast cancer patients matched for age, education and time since treatment were recruited as a comparison group. RESULTS: Global cognitive impairment was observed in 8% of high-dose versus 13% of standard-dose compared with 3% of early-stage breast cancer patients. Compared with normative data, all patient groups performed worse on one attention subtest measuring the simple reaction time (P < 0.001 in each case). By contrast, no significant between-group differences on the late neuropsychological outcome were found. CONCLUSIONS: Five years after treatment, standard-dose patients were slightly, but not significantly, more impaired in cognitive performance than high-dose patients.

Antineoplastic Agents↗
PubMed1991

[Diabetes mellitus in children under 2 years of age].

We studied the clinical course in 18 children who were admitted to our department during the time period 1973-87 for onset of diabetes mellitus before two years of age. During these years a total number of 242 diabetics (0-14 years) were admitted from a population of approximately 100,000 children. The 18 cases showed a sex ratio (female/male) of 12/6. In nine cases the duration of symptoms before admittance to hospital was one week or less. The onset of the disease showed no particular seasonal pattern. 13 patients presented with a blood glucose of 25 mmol/l or more. Severe ketoacidosis was observed in nine patients. None of the patients exhibited any well-defined remission period. In the course of the disease, 11 patients had frequent hypoglycemic episodes, nine patients had convulsive attacks, poor metabolic control was evident in five cases, and major psychological problems were frequently encountered. In conclusion, diabetes mellitus in small children can be extremely difficult to manage, both from a medical and a psychosocial point of view. All efforts should be made to support the families of children with this disease.

Age Factors↗
PubMed1989

[Child abuse and neglect: medical aspects].

Child abuse and neglect is a global problem that effects children of all ages and social classes. The article discusses some of the medical aspects of child abuse. As the presence of "proof" in the form of an obvious physical injury is often lacking, it is of the utmost importance that professional people are sensitive to the signs and symptoms (signals) to which abuse and neglect may be one of many possible diagnoses. Teamwork between the relevant professional groups is essential to solve the problem.

Child↗
PubMed1980

Complex chromosomal rearrangement leading to partial trisomy 22.

We have examined a boy with a peculiar facial appearance and mental retardation. Cytogenetic studies showed 47,XY, monosomy 22, two marker chromosomes, M1 and M2. The karotype is interpreted as functionally partial trisomy 22. Chromosome analyses of both parents and three sibs were normal.

Child, Preschool↗
PubMed1978

Trisomy 12p syndrome. Evaluation of a family with a t(12;21) (p12.1;p11) translocation with unbalanced offspring.

Two brothers (Nos. 1 and 3), with physical and mental retardation and many other clinical characteristics in common, were both trisomic for 12p(ter leads to 12.1) and monosomic for 21p. Their mother (No. 5), the maternal grandmother (No. 7), aunt (No. 8), and a first-cousin (No. 9) were balanced translocation carriers, 46 rep (12;21) (p12.1;p11). Another cousin (No. 10) had Down syndrome: he had two normal 21 chromosomes in addition to both translocation chromosomes. A sister (No. 2), who died at the age of 1 year without being karyotyped, had several phenotypical features in common with her brothers. Our two cases of trisomy 12p (ter leads to 12.1) were compared with eight cases of trisomy 12p described earlier, and the following common characteristics were found: severe mental and physical retardation; flat and round, broad face with prominent cheeks; flat and broad nasal bridge with short nose; anteverted nostrils and large philtrum; broad and prominent lower lip; low-set or slanting ears, poorly formed with folded helix, prominent antihelix and deep concha; short neck; short sternum; "spade"-shaped fingers, the fifth being short; bilateral genu valgum; bilateral pes planus and talus valgus; increased space between the first and second toes; generalized hypotonia; and certain dermatoglyphic characteristics. An elevated serum lactate dehydrogenase (LDH) was measured in four cases.

Abnormalities, Multiple↗