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Biomedical subjects

L Seijo

Publications and source records attributed to L Seijo.

9 recordsLinked to original sources
PubMed1995

Endometrial adenocarcinoma with choriocarcinomatous differentiation in an elderly virginal woman.

A 70-year-old virginal woman underwent hysterectomy and bilateral salpingo-oophorectomy for endometrial carcinoma. Gross examination of the surgical specimen showed normal ovaries and fallopian tubes, an enlarged uterus with several intramural leiomyomata, an endometrium completely carpeted by cancer, and, additionally, a necrotic and hemorrhagic nodular mass that protruded into the endometrial cavity. Histologic examination showed a widespread and superficially invasive, moderately differentiated endometrial adenocarcinoma that merged with a choriocarcinoma. Immunohistochemical studies showed cytoplasmic staining for human chorionic gonadotrophin in syncytiotrophoblast cells, cytotrophoblast-like cells and rare adenocarcinoma cells. A discussion of previously reported similar cases and possible mechanisms of dual differentiation in tumors, as well as comments on histogenesis are included.

Adenocarcinoma↗
PubMed1994

Meningioma phospholipid profiles measured by 31P nuclear magnetic resonance spectroscopy.

Fourteen cases of intracranial meningioma were characterized after chloroform/methanol extraction by 31P nuclear magnetic resonance (NMR) spectroscopy at 202.4 MHz. Each phospholipid class detected in the extracts was identified and quantitated in terms of its molar percentage relative to the total phospholipids measured. The following phospholipids were assayed by 31P NMR: phosphatidylglycerol, phosphatidic acid, diphosphatidylglycerol, ethanolamine plasmalogen, phosphatidylethanolamine (PE), lysophosphatidylinositol, phosphatidylserine, sphingomyelin, lysophosphatidylcholine (LPC), phosphatidylinositol (PI), sphingosylphosphorylcholine and phosphatidylcholine. In addition, two unidentified phospholipids were detected with resonances at 0.13 and -0.78 ppm, respectively. Three distinct types of spectra were obtained on the extracts and grouped accordingly for comparison purposes. Type 1 tumors showed unusual 31P NMR profiles with low levels of PE and PI and elevated levels of LPC; type 2 tumors were characterized by low levels of the ethanolamine phospholipids and near equivalent levels of PI and LPC. The spectra of type 1 and type 2 tumors were characteristic of degenerative cells that lacked membrane permeability associated with loss of ethanolamine plasmalogen in the presence of significant phospholipid turnover. Meningiomas belonging to the third spectral type showed characteristics similar to those of normal tissues with normal levels of PE and ethanolamine plasmalogen, as well as very low levels of LPC relative to PI. Type 3 tumors lacked the characteristic signs of degeneration noted in type 1 and type 2 tumors. The data corroborate and augment in vivo spectroscopic findings reported earlier and demonstrate the value of 31P NMR spectroscopic phospholipid analysis on lipid extracts for the characterization of meningiomas.

Humans↗
PubMedDate not supplied

MRI findings in adenosquamous carcinoma of the gallbladder.

In this report, we present the MRI findings of adenosquamous carcinoma of the gallbladder, a rare type of gallbladder malignancy. MRI examination not only helped established the diagnosis but also accurately depicted the extent of involvement of the adjacent liver. The ability to image in multiple planes was also useful in assessing the anatomic location of the tumor and in determining that the patient could be treated with surgical resection.

Aged↗