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Biomedical subjects

L Serup

Publications and source records attributed to L Serup.

8 recordsLinked to original sources
PubMed1987

Fundus fluorescein angiography in generalized scleroderma.

Fundus affliction with generalized scleroderma was studied in 21 patients by ophthalmoscopy, fundus ocular photography and fluorescein angiography. Slitlamp examination of the anterior chamber, the iris and the lens revealed no evident affections. Neither did ophthalmoscopy reveal obvious abnormalities related to scleroderma. Abnormalities of pigmentation were not noted. Visual acuity was normal in 20 patients, and 1 patient had reduced visual acuity due to macular degeneration. Fundus fluorescein angiography was within normal physiological variation in 14, and definitely abnormal in 7 patients as assessed independently by 2 ophthalmologists. Angiographic abnormalities consisted of variable hyperfluorescence of the pigment epithelium layer, and, additionally, in 2 cases minute hyperfluorescence of the retinal layer. These angiographic abnormalities indicated affection of the retinal pigment epithelium probably caused by a vascular lesion of the choroidal layer. Retinal vessels were in general not affected. In conclusion, the choroidal vasculature appears affected in 1/3 of patients with generalized scleroderma as assessed by fundus fluorescein angiography.

Adult↗
PubMed1986

Influence of pregnancy on diabetic retinopathy.

A prospective study of the influence of pregnancy on diabetic retinopathy was started at Rigshospitalet, Copenhagen in 1979. At present 145 women with insulin-dependent diabetes have been included. Preliminarily, it seems that women belonging to White classes B and C do not develop persistent retinopathy as a consequence of pregnancy. Women with retinopathy at the onset of pregnancy deteriorate in 50% of the cases, but post-partum regression is common. Development of proliferative changes is exceptional, and proliferations developed during pregnancy in most cases disappear spontaneously after delivery. Consequently, treatment with photocoagulation during pregnancy and in the early post-partum period should be restricted. Close ophthalmological supervision during pregnancy is essential and the ophthalmologist must be aware of the spontaneous course of diabetic retinopathy in relation to pregnancy.

Diabetes Mellitus, Type 1↗
PubMed1985

Increased central cornea thickness in localized scleroderma (morphoea).

The central cornea thickness (CCT) was measured in 17 patients with localized scleroderma (morphoea) by the Haag-Streit pachymeter. Results were compared with measurements in healthy persons matched with respect to sex and age. CCT was increased (p 0.01) in patients with morphoea (mean 0.535 mm, range 0.510-0.580, SD 0.0217) as compared to the controls (mean 0.511 mm, range 0.490-0.525, SD 0.0094). In 9 (53%) of the patients CCT was more than mean + 2 SD in the controls. CCT was correlated to the duration of morphoea (correlation coefficient 0.660, p 0.01). It is discussed that the increase in cornea thickness may be a sign of minimum cornea "swelling" with alterations of the glycosaminoglycans of the corneal stroma as a possible background. The study demonstrates that morphoea is not simply a local disease confined to the plaques of the skin.

Adolescent↗
PubMed1984

Increased central cornea thickness in systemic sclerosis.

Central cornea thickness (CCT) was measured in 32 patients with systemic sclerosis by the Haag-Streit pachymeter with improved centrality. Results were compared with measurements in 29 healthy adults matched with respect to sex and age. CCT was increased (P less than 0.001) in patients with systemic sclerosis (mean 0.56 mm, average SD right and left side 0.0297 mm) as compared to the controls (mean 0.51 mm, SD 0.0109 mm). CCT of right and left eye was increased in 69% and 72% of patients with systemic sclerosis as compared to controls (mean 0.51 mm +/- 2 SD). CCT increased during the first 8 years of the disease (correlation coefficient 0.593) reaching a plateau after 8 years (correlation coefficient 0.005). CCT did not increase during medical treatment with collagen inhibitors. Measurement of CCT may be useful as a supplement to other quantitative methods for diagnosis and control of systemic sclerosis.

Adult↗
PubMed1980

Interstitial deletion of the long arm of chromosome 7.

Chromosome studies were carried out in a girl because of psychomotor retardation and difficulty in swallowing. The girl was admitted to hospital for the first time when 25 months old. The most characteristic signs revealed by the physical examination were short distal ulnar phalanges, clitoral hypertrophy, and very thin outer ear cartilages. An interstitial deletion of the long arm of chromosome 7 was observed: 7q22::7q31. Laboratory investigations revealed a remarkably high levels of IgG, immunoglobulin, and an elevated value of serum FSH. No evidence of gene loci located at the deleted part of chromosome 7 were found.

Child, Preschool↗