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Biomedical subjects

L Shahinian

Publications and source records attributed to L Shahinian.

17 recordsLinked to original sources
PubMed1997

Dilute topical proparacaine for pain relief after photorefractive keratectomy.

PURPOSE: The purpose of the study is to determine whether there is a nonanesthetic and nontoxic concentration of topical proparacaine that can be applied repeatedly to the cornea to reduce pain after photorefractive keratectomy (PRK). METHODS: Part I: To determine a nonanesthetic concentration, the corneal sensitivity of 50 healthy volunteers was assessed using aesthesiometry before and after a drop of either 0.01%, 0.025%, 0.05%, 0.1%, or 0.2% topical proparacaine. Ten volunteers similarly were tested with multiple doses of 0.05% proparacaine. To evaluate toxicity, ten healthy volunteers self-administered 0.05% proparacaine to one eye and placebo to the other eye every 15 minutes for 12 hours on day 1 and every hour for 12 hours on days 2 through 7. Subjects were assessed throughout the week using visual acuity, slitlamp examination, aesthesiometry, and ultrasonic pachometry. Part II: In a prospective, double-masked study, 34 patients who underwent PRK (48 eyes) self-administered either topical 0.05% proparacaine or placebo for 1 week after PRK as needed to reduce pain. Patients recorded their pain score before and after drop use and answered a pain-relief questionnaire. RESULTS: Part I: Proparacaine concentrations greater than or equal to 0.1% eliminated sensation from some corneas; concentrations of less than or equal to 0.05% were never fully anesthetic. No corneal toxicity was observed except for some minimal punctate staining in both treatment and placebo eyes. Part II: Patients in the treatment group had significantly more pain relief (P < 0.001) for a longer period (P < 0.001) than did patients in the control group. Average change in pain score was significantly greater in the treatment group (P < 0.002). No significant difference in the number of days needed to reach complete epithelial healing was found between the two groups (P < 0.18). CONCLUSIONS: Dilute (0.05%) topical proparacaine is nonanesthetic and nontoxic, and can be used safely for at least 1 week to reduce pain after PRK.

Administration, Topical↗
PubMed1992

Histologic study of healing after ab interno laser sclerostomy.

We examined the histologic characteristics of healing after ab interno laser sclerostomy in a human eye. A KTP 532 green laser coupled to a 300-microns quartz fiberoptic probe was used to create an ab interno sclerostomy in a terminally ill patient with pigmentary glaucoma. The intraocular pressure increased five days postoperatively and did not respond to medical treatment. The patient died six weeks postoperatively of metastatic lung cancer. Histopathologic analysis showed a patent 150-microns scleral lumen from the anterior chamber to the episclera, surrounded by a 300-microns zone of acellular thermal damage. There was no healing of the lumen. The subconjunctival end of the lumen was capped with a thick episcleral scar, which caused the failure of the operation.

Cicatrix↗
PubMed1987

An improved radial marker for radial keratotomy.

Radial marks on the peripheral cornea in radial keratotomy can lead to confusion during incision placement. I have designed and successfully used a small radial marker that indicates the starting position for each incision, but does not mark the peripheral cornea.

Humans↗
PubMed1984

Contact lens wear.

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Contact Lenses, Hydrophilic↗
PubMed1984

Corneal valance: a tear film pattern in map-dot-fingerprint corneal dystrophy.

A scalloped line of tear film thinning (corneal valance), running horizontally across the top third of the cornea, was readily seen with slit lamp, fluorescein, and blue filter in 25 patients. Careful retrospective examination of these patients revealed barely discernible map and fingerprint lines corresponding to the areas of tear film irregularity. A corneascope photograph suggests that the tear film thinning in corneal valance is caused by localized elevations of the epithelial surface. The importance of corneal valance is that it is easily seen, and makes possible the diagnosis of map-dot-fingerprint corneal dystrophy in cases that might otherwise be misdiagnosed or overlooked.

Adult↗
PubMed1982

Iridocyclitis.

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Complement System Proteins↗
PubMed1978

Retrolental fibroplasia: a new analysis of risk factors based on recent cases.

Over an 18-month period, four severe and eight mild cases of retrolental fibroplasia (RLF) were diagnosed. All infants had gestational age less than 34 weeks. While the percentage of infants with RLF increased with decreasing gestational age, the severity of RLF was not related to birth weight or gestational age. These RLF infants were compared with premature infants having normal fundi. The arterial blood gas values in the first week of life were similar for the two groups. However, during the subsequent weeks of oxygen therapy, the infants who developed severe RLF had a significantly greater number of hours of capillary oxygen tension at undesirable levels (Pcap O2 greater than 50 mm Hg) than the mild RLF or control infants. These results suggest that infants may be at greatest risk of severe retinal damage from oxygen relatively late in the course of their oxygen therapy.

Humans↗
PubMed1978

Diagnosis and treatment of ocular rosacea.

Eighteen patients with ocular rosacea were treated with oral tetracycline which resulted in marked improvement in all patients. Approximately one half of the patients were able to taper and stop the medication without recurrence of symptoms. The remaining have tapered their medication but could not stop without recurrence of symptoms. The majority of the patients in the series had Staphylococcus aureus on their conjunctiva and lids before and after surgery.

Adult↗
PubMed1977

Postoperative complications with protruding monofilament nylon sutures.

Cut ends of 10-0 monofilament nylon sutures protruded and caused various combinations of severe pain, conjunctival inflammation, tarsal conjunctival ulcerations, eyelid edema, and corneal epithelial erosions in six patients postoperatively. These changes occurred one to three weeks after keratoplasty and one to three months after cataract surgery. In all six patients the signs and symptoms cleared after we trimmed or removed the offending sutures.

Adult↗
PubMed1976

Peters' anomaly with the fetal transfusion syndrome.

Of identical twins with the fetal transfusion syndrome, the second twin who was anemic and hypoxemic from early gestation had Peters' anomaly by histologic examination of the host cornea excised during corneal transplantation at 7 months of age. The absence of a normally positioned lens with the incorporation of lens epithelium, capsule, and cortex within the posterior corneal stroma suggested a developmental disturbance in the separation of the lens from the cornea. The severe lenticular disturbance, microphthalmos, and fetal growth retardation in this case reflected early anemia and the resultant hypoxemia. To our knowledge, this is the first time that the fetal transfusion syndrome and Peters' anomaly have been associated.

Corneal Diseases↗
PubMed1966

Decompression of the facial nerve. A surgical emergency.

The chance of return of normal function in cases of facial paralysis is enhanced by early surgical decompression and repair of the facial nerve. Modern precision testing is of considerable aid in prognosis as well as diagnosis. Faradic testing and electromyography can offer relatively early information as to the possibility of permanent facial deformity. Now that microscopic surgical techniques have considerably facilitated operations on the facial nerve, early operation is the treatment of choice in such cases.

Adolescent↗