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Biomedical subjects

L Shea

Publications and source records attributed to L Shea.

11 recordsLinked to original sources
PubMed1975

Rubella and measles serosurvey among a nonurban pediatric population.

A serologic survey for rubella and measles immunity was conducted to determine the immunity levels among a nonurban, relatively isolated pediatric population. Among 1,273 students in grades kindergarten through 9, the overall susceptibility rate was 24.3% for rubella and 16.3% for measles. There was significant variation in susceptibility rates among the various grades and schools involved. The susceptibility rates were similar to those found for urban populations. The results indicated that vaccination efforts for the population have been partially successful, but additional effort was needed.

Adolescent↗
PubMed1975

Reye's syndrome: epidemiologic and viral studies, 1963-1974.

Fifty-eight children with Reye's syndrome (RS) confirmed by liver biopsy were treated at the University of Cincinnati between 1963 and 1974. Cases were clustered in the winter and spring with the peak in February and March. These coincided with the occurrence of influenza and, numerically, were associated more closely with influenza B than with influenza A. Six of the 58 cases were associated with chickenpox. Twenty-six children with RS were seen from 1963 to 1971, before the beginning of a systematic epidemiologic and virologic study. Viral infection was documented in either the patient or a contact in only 19% of those studied. Between 1971 and 1973, after the study was initiated, 16 cases of RS were diagnosed and viral infection was confirmed in 56% of these. In 1974, an epidemic of RS occurred during an influenza B epidemic and viral infection was found in either the patient or a contact in 81% of 16 cases. This study demonstrates that an association with viral infection can be proven in the majority of cases of RS when an intensive investigation is undertaken. During this study no significant environmental toxic exposures could be idenified. Most children had taken aspirin and other medications, and seven children had a history of excessive aspirin ingestion.

Adolescent↗