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Biomedical subjects

L Sheets

Publications and source records attributed to L Sheets.

5 recordsLinked to original sources
PubMed1989

Liver transplantation.

Liver transplantation celebrated its twenty-fifth anniversary in 1988. However, only in the last decade has it been accepted as a viable treatment alternative for patients with end-stage liver disease. There currently are over 70 centers in the United States with liver transplant programs. Over 1500 transplants were performed in 1988, and there were 644 people awaiting suitable liver donors, with an average of 150 to 200 patients added to the list each month. This growth has resulted from many factors, including improved operative techniques and anesthetic management, immunosuppressive therapies, and improvements in donor recovery, which has served to increase the acceptable organs available for transplantation. The future of liver transplantation, however, may be somewhat uncertain. Will the cost of patient care continue to be supported by the economy? The goal of liver transplantation is simple: to provide the patient with a better quality and longer life. The question remains, is this a goal that society will deem financially feasible?

Adaptation, Psychological↗
PubMed1987

Gait analysis of chicks following treatment with tri-ortho-cresyl phosphate in ovo.

Chick embryos were treated during late embryonic development with tri-ortho-cresyl phosphate (TOCP), an organophosphate compound that causes delayed neurotoxicity in humans and some other species. Embryos were treated on incubation d 14 with either 62 or 250 microliters TOCP/kg egg. The higher dose reduced the number hatched, and signs of cholinergic toxicity were apparent in the newly hatched chick. All chicks that survived this dose were unable to stand. Recovery from the cholinergic effects occurred within a few days after hatching, but the chicks remained severely ataxic through 3 wk of observation. The mortality of embryos treated with 62 microliters TOCP/kg egg was not higher than that of controls, and young chicks showed no overt signs of cholinergic toxicity or ataxia. Motor impairment was detected by measuring gait parameters. These chicks had a short stride and walked with a more open angle of foot placement. These are adjustments in gait that provide a more steady base of support. The change in gait developed over a 3-wk period after hatching. The hindlimb motor impairment detected at both doses is consistent with neuropathy such as is seen in the adult chicken. The value of gait analysis is the ability to quantify effects that are not apparent by simple observation.

Animals↗
PubMed1985

Morphologic alterations in leg muscles of chicks treated with triorthocresyl phosphate in ovo.

Chick embryos were injected on incubation Day 14 with 62 microliter of triorthocresyl phosphate (TOCP)/kg egg. Muscles of the leg were examined from 5 to 25 days after hatching. The sartorius from the thigh and the external gastrocnemius and peroneus longus from the tibial leg region were compared for muscle fiber size and end-plate length over this period. Treated chicks showed no acute toxic effects or overt ataxia and were equal in body weight to controls. At 5, 15, and 25 days after hatching, morphologic alterations consistent with denervation were detected. Muscle fibers were smaller than controls on Day 5 and were hypertrophic on Days 15 and 25. On Day 5 growth of fibers was retarded, an effect consistent with denervation, and the subsequent hypertrophy is predicted as compensation for denervated fibers. Small end plates were seen on Day 15, characteristic of end plates that were delayed in development by denervation. Each of these differences was greater in the tibial muscles than in the more proximally located sartorius. This is consistent with a distal neuropathy, such as that caused by TOCP in adult hens. Some recovery was apparent at the low dose 25 days after hatching. It is suggested that this resulted from reinnervation by repaired axons. This study of the myoneural apparatus and muscle fiber response to TOCP adds evidence to the possibility that the developing chick embryo may develop delayed neuropathy from organophosphorus compounds which produce this effect in adult hens.

Animals↗
PubMed1985

Peripheral nerve damage in chicks following treatment with organophosphorus compounds in ovo.

Chick embryos were treated with tri-o-cresyl phosphate (TOCP) or leptophos, organophosphorus compounds that cause delayed neurotoxicity. Embryos received either TOCP (62 or 250 microliter/kg egg) or leptophos (125 to 750 mg/kg egg) Day 14 of incubation and were examined after hatching for nerve damage. The high doses caused high embryo mortality. Chicks which survived the high doses were grossly ataxic from hatching until the study was ended at 3 weeks posthatching. On Posthatching Day 2, many degenerating nerve fibers were observed in the profundus/superficialis peroneus nerve in chicks surviving the high doses. TOCP-treated chicks were followed in detail for neuromuscular changes. Twenty days after hatching there were fewer large nerve fibers in the distal ischiadic nerve compared with controls and the largest nerve fibers were absent in the peroneus profundus nerve. Consistent with the evidence of denervation there was increased terminal branching of motor axons in femoral (sartorius) and tibial (external gastrocnemius and peroneus longus) leg muscles. The leg nerves of chicks treated with the low dose of TOCP did not show either an excessive number of degenerating nerve fibers or a detectable loss of large nerve fibers. However, terminal branching of motor axons was increased in the external gastrocnemius and peroneus longus muscles of 5- and 15-day-old chicks, followed by recovery by Day 25. The evidence is interpreted as a distal axonopathy in chicks treated with TOCP during late embryonic development.

Animals↗