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Biomedical subjects

L Shemen

Publications and source records attributed to L Shemen.

16 recordsLinked to original sources
PubMed2001

Malignant lymphoepithelial lesion of the parotid gland: a case report and review of the literature.

Malignant lymphoepithelial lesions are rare tumors of the major salivary glands. They most often occur in Asians and Greenland Eskimos and are strongly associated with Epstein-Barr virus infection. We report a case of a malignant lymphoepithelial lesion of the parotid gland that developed in an Italian-American woman whose serology was positive for Epstein-Barr virus antibody. The patient underwent a left total parotidectomy and upper neck dissection, followed by radiation therapy. At the 2-year follow-up, she remained free of disease.

Carcinoma, Squamous Cell↗
PubMed1997

Preoperative and postoperative nasal septal surgery assessment with acoustic rhinometry.

INTRODUCTION: Acoustic rhinometry is a relatively new tool used for the measurement of the geometry of the nasal fossa. We hypothesized that acoustic rhinometry would be useful for preoperative and postoperative assessment of patients undergoing septal surgery. METHODS AND MATERIAL: Twenty-four patients undergoing septal surgery performed by two surgeons underwent preoperative and postoperative rhinometry. The indications for surgery were nasal obstruction caused by a deviated nasal septum. Rhinometry was conducted with the Eccovision Acoustic Rhinometry System (Hood Laboratories). Analysis of the data was performed with the Kwikstat program (Texasoft) and Excel (Microsoft). RESULTS: Subjective improvement in nasal patency was significantly correlated with improvement in acoustic rhinometry. CONCLUSIONS: Acoustic rhinometry is valuable in objectively confirming nasal patency after nasal septal and turbinate surgery.

Acoustics↗
PubMed1995

Malignant teratocarcinosarcoma of the sphenoid sinus.

We have presented the first reported case of malignant teratocarcinosarcoma arising in the sphenoid sinus treated successfully with surgery and radiation therapy. The patient shows no signs of recurrence 5 years after surgery. The combined head and neck/neurosurgical approach using complete rhinotomy and medial maxillectomy with transsphenoid/transethmoid approach is advocated for sphenoid sinus tumors of this type.

Carcinosarcoma↗
PubMed1991

Rosai-Dorfman disease involving the premaxilla.

Sinus histiocytosis with massive lymphadenopathy (SHML), introduced in 1969 by Rosai and Dorfman, is a benign and self-limited (albeit often relapsing) pseudolymphomatous entity with characteristic histopathologic features. Although the presence of massive cervical lymphadenopathy often aids in the diagnosis of SHML, the disease may present in the absence of detectable nodal involvement (Rosai-Dorfman disease). Therefore, the physician must be aware of such extranodal presentations. A recent review of the 365 cases in the SHML registry has revealed a preponderance of eyelid and/or orbital involvement; only 26 cases were found with subcutaneous or soft tissue involvement in areas other than the eyelid and/or orbit. This is a case report of one such atypical presentation of SHML without clinically apparent lymphadenopathy or eyelid or orbital involvement.

Adult↗
PubMed1989

Tracheoesophageal puncture for voice restoration after extended laryngopharyngectomy.

Tracheoesophageal puncture was performed in ten of our patients undergoing extended laryngopharyngectomy. Three fistulas were allowed to close, and two patients were dissatisfied with their results, which allowed for an overall 50% success rate in this subgroup. The resultant voice was objectively compared with similar groups of patients undergoing primary and secondary tracheoesophageal puncture after standard laryngectomy. There was no significant difference in maximum phonation time, average speaking intensity, and average fundamental frequency between these groups. However, the maximum intensity and average intensity were significantly lower for the flap group. Our results indicate that tracheoesophageal puncture should be attempted in patients undergoing the extended procedure, notwithstanding a lower expected success rate.

Aged↗
PubMed1988

Microvascular revascularization of the tongue.

Revascularization of the tongue, employing microvascular techniques, is useful in cases where the blood supply to this organ must be interrupted to allow for adequate exposure or for adequate margins. A case is presented in which the left lingual artery was divided for purposes of exposure and the right artery was interrupted to encompass the entire tumor. This patient also underwent a total laryngopharyngectomy with jejunal free flap interposition. The blood supply of the tongue was successfully reestablished by anastomosing the right lingual artery to the right facial artery. The patient made an uneventful recovery.

Anastomosis, Surgical↗
PubMed1986

Primary tracheoesophageal puncture for voice restoration.

A 93 percent success rate of voice restoration after primary tracheoesophageal puncture was achieved in 15 patients. Patients were usually able to talk within 3 weeks after laryngectomy. Male patients without chronic obstructive lung disease achieved better results. The incidence of complication after this procedure were not significantly different from a group of 111 patients who underwent laryngectomy alone. Finally, early speech acquisition provides a substantial psychologic boost for the patient undergoing total laryngectomy.

Adult↗
PubMed1983

Melanosis coli. Changes in appearance when associated with colonic neoplasia.

In 30 cases of colonic neoplasia associated with melanosis coli, proliferating or neoplastic colonic epithelium was notable within the melanotic colons by virtue of a striking absence of pigmentation. Microscopically this characteristic was found to be due to an absence or diminution of pigment-laden macrophages in the lamina propria underlying such lesions. Therefore, the absence of pigment-laden macrophages can be considered a marker for abnormally proliferating epithelium. This characteristic may denote a cellular or humoral change mediated by macrophages in association with neoplastic epithelium.

Colonic Diseases↗
PubMed1979

Sodium-independent, high-affinity binding of [3H]gamma-aminobutyric acid in human neurological disorders.

With respect to [3H]GABA-binding in material prepared from human post-mortem brain, the following observations have been made: (1) The [3H]GABA binding site in the cerebellum has the pharmacological characteristics of the physiological GABA-receptor observed in other species. Together with the post-mortem stability exhibited for [3H]GABA-binding, this provides an approach for determining the functional state of the GABA-receptor in various disease states; (2) In Parkinson's disease [3H]GABA-binding in the substantia nigra is significantly decreased whereas that in the putamen and caudate nucleus is unaltered. The former finding likely indicates that GABA binding sites (receptors) occur on nigral dopaminergic cell bodies and/or dendrites. The latter finding may signify that relatively few of the striatal [3H]GABA binding sites occur on dopaminergic nerve terminals in the human caudate or putamen; (3) In Huntington's disease [3H]GABA binding was decreased in the caudate nucleus and putamen, in parallel wih the massive cell loss and gliosis observed in this condition. Membranes prepared from cerebellar tissue of these patients possessed an increased affinity for [3H]GABA-binding; (4) Pre-treatment of cerebellar membranes from control brains with Triton-X-100 (0.02%) or phospholipase-C (0.001 units) results in kinetic changes very similar to those observed in Huntington's brains. In contrast, such treatment was virtually without effect on the IC50 or KD for [3H]GABA on cerebellar membranes prepared from Huntington's brains; (5) These results imply that a phospholipid, possibly related to phosphoglycerolethanolamine, is altered in the membrranes of Huntington's patients and that this phospholipid normally has a role in controlling accessibility to the GABA-receptor.

Binding, Competitive↗
PubMed1977

Distribution of high affinity sodium-independent [3H]gamma-aminobutyric acid [3H]GABA binding in the human brain: alterations in Parkinson's disease.

The regional distribution and properties of the sodium-independent "specific" binding of [3H]GABA to membranes prepared from human brains (control and Parkinsonian patients) have been investigated. The affinity of [3H]GABA for the binding site was similar for human cerebellar cortex (Kd = 3.4 x 10(-7) M) and whole rat brain brain (Kd = 5.1 x 10(-7) M) and was inhibited by bicuculline (ID50 = 2.2 X 10(-5) M). In the normal human brain the cerebellar cortex demonstrated the highest number of binding sites, in accordance with the large number of GABA interneurons in this structure. The hippocampus also displayed a high capacity to bind [3H]GABA, whereas cerebral cortical areas showed a lesser capacity. [3H]GABA binding was similar in many regions of the basal ganglia (amygdala, putamen, caudate or accumbens) but was lower than that for the cortical regions. The binding of [3H]GABA to membranes from the substantia nigra, thalamus and internal or external pallidum was lower than for the above regions. Subcortical white matter did not exhibit specific binding for [3H]GABA. In membranes prepared from Parkinsonian patients [3H]GABA binding was greatly decreased in the substantia nigra, but not in other brain areas examined. From this observation it was concluded that there are [3H]-brain areas examined. From this observation it was concluded that there are [3H]-GABA binding sites on the cell bodies (or dendrites) of the nigral dopamine neurons.

Adult↗
PubMedDate not supplied

Multifocal adult rhabdomyomas of the head and neck.

Rhabdomyomas are usually found in the myocardium. Of the extracardiac sites, the head and neck is the most frequent region where this rare tumor arises. Multifocal head and neck lesions have only been described in 11 cases. We herein present two additional multifocal lesions.

Aged↗
PubMedDate not supplied

Selecting variants in pharyngeal reconstruction.

A dramatic change in the techniques of immediate pharyngeal reconstruction in the last 10 years is largely due to the availability of myocutaneous flaps, microvascular techniques, and the increasing popularity of the "gastric pull-up" operation. The experience of the Head and Neck Service of Memorial Sloan-Kettering Cancer Center in repair of the pharynx following pharyngeal resection between 1974 and 1983 is reviewed and the changing trends in the philosophy of pharyngeal reconstruction are highlighted. The methods of reconstruction used were deltopectoral flap, gastric pull-up, free microvascular bowel transfer, and pectoralis myocutaneous flap. The indications, morbidity, effectiveness, and complications for each of these procedures are discussed. The optimal reconstructive methods for partial and total pharyngeal reconstruction are as follows: 1) primary closure for defects not exceeding one third of the circumference of the pharynx; 2) pectoralis myocutaneous flap repair for pharyngeal defects with loss of up to 70% of the circumference of the pharynx; 3) gastric pull-up with pharyngogastrostomy for defects exceeding 70% of the circumference of the pharynx; 4) gastric pull-up for all pharyngoesophageal defects where the lower margin of resection is below the tracheostome; and 5) reversed pectoralis myocutaneous flap with split thickness skin graft on the muscle for secondary closure of the pharyngostome.

Colon↗