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Biomedical subjects

L Shirova

Publications and source records attributed to L Shirova.

At least 19 recordsLinked to original sources

Effect of oxadiarrhot on some mechanisms of the immune system.

The preliminary application of the preparation Oxadiarrhot has no effect on the progress and the result of bacterial and mixed (bacterial-viral) infections. In animals treated with the preparation antigen-reactive and antibody-productive cells show insignificant decrease in number. There is no essential influence of the preparation on the mononuclear phagocytes system--the alveolar macrophages and polymorphonuclears do not change their functions.

Animals↗

[The immunomodulating properties of a macro glycopeptide isolated from serum. II. The activation of macrophages and polymorphonuclear cells].

The stimulating properties of three fractions of a glucomacropeptide consisting of different carbohydrate and peptide components were studied. The phagocytic activity of polymorphonuclears was increased on the 24th hour and of macrophages on the 3rd day after application of the preparations to mice. In vitro fraction 3 stimulates the lysozyme activity and the synthesis of proteins and Clq of the macrophages complement. These properties of the cells are collaborated by the established ultrastructural changes. The different composition of the fractions determines their immunostimulating effect.

Adjuvants, Immunologic↗

[Serum complement level (C'H5O) during treatment of rheumatoid arthritis patients].

Decreased total complement serum level (C'H50) was established in 72 per cent of the 78 patients examined, associated most likely with the developing processes of antigen-antibody reaction and the severe course of the illness. The applied treatment with different antirheumatic remedies, according to their mechanism of action, determined the respective changes in the complement level. Indomethacinum and chinoline derivatives induce complement values elevation, whereas the corticosteroids, salicylate and pyrazolone preparations lead to the complement values normalization.

Adrenal Cortex Hormones↗