Biomedical subjects

L Sibert

Publications and source records attributed to L Sibert.

57 records · Page 4Linked to original sources

PubMedDate not supplied

[Hypothyroidism and immunotherapy using interferon or interleukin for metastatic renal adenocarcinoma].

The authors report a case of hypothyroidism occurring during cytokine treatment of metastatic renal cancer. This is a relatively rare complication of immunotherapy, whose aetiopathogenesis remains unclear. Possible hypotheses include an autoimmune process or direct toxicity. Thyroid function tests at the start of immunotherapy and regular monitoring are therefore recommended during treatment with interferon and/or interleukin. If hypothyroidism is not recognised, its clinical symptoms and signs could be attributed to cytokine toxicity, leading to unwarranted discontinuation of treatment when L-thyroxin replacement therapy would have been sufficient.

Adenocarcinoma↗

PubMedDate not supplied

[Drainage of a lymphocele after kidney transplantation, using laparoscopy].

The authors report a case of transperitoneal laparoscopic drainage of a recurrent, compressive lymphocele occurring 3 months after cadaver renal transplantation. The technique consists of creating a transperitoneal breach and resecting the walls of the lymphocele to ensure internal drainage followed by suture of a slip of greater omentum over the opened lymphatic cavity. Preoperative aspiration and computed tomography precisely defined the site of the lymphocele in relation to urinary and vascular structures, confirmed the lymphatic nature of the collection and excluded the presence of infection. This technique has the same indications as classical surgical internal drainage and can be used to easily perform the same procedures. Because of its simplicity and low morbidity, laparoscopic drainage can be proposed as first-line treatment for large, symptomatic and recurrent posttransplantation lymphoceles, in the absence of infection and provided the lymphocele is in an accessible site and the operator has a sufficient experience of laparoscopic techniques.

Adult↗

PubMedDate not supplied

[The role of percutaneous puncture alcohol sclerotherapy in the treatment of symptomatic kidney cysts].

OBJECTIVE: The objective of this study was to prospectively evaluate the results of percutaneous alcohol sclerotherapy of symptomatic renal cysts in adults. MATERIAL AND METHODS: We report a series of 13 patients with a mean age 69 years (47-75 years). The operative indication was pain (9 cases), urinary tract compression (3 cases), very large cyst (1 case). The preoperative assessment (site and dimensions of the cyst) always included ultrasonography (mean diameter: 75 mm). CT scan, for morphological assessment, was performed in 10 cases. The proposed technique consists of intraoperative ultrasound detection followed by puncture of the cyst (under local or general anaesthesia). Insertion of a Malécot tube allows drainage of the cyst with collection of bacteriological and cytological samples and opacification and instillation of an alcoholic solution (98% ethanol) corresponding to one half of the cyst volume, with clamping for 20 minutes. Postoperative surveillance is based on clinical examination and ultrasonography (2 months, 6 months, 1 year). RESULTS: The procedure was very well tolerated in every case, with external drainage for 48 hours. Clinical and ultrasonographic regression was complete in 90% of cases, with a mean follow-up of 15 months (4-40 months). In two cases, ultrasonographic regression was incomplete (diameter less than 20 mm), but the patients remained asymptomatic. CONCLUSION: Our results are concordant with those of most studies reported in the literature and this method therefore appears to be a preferred technique for the treatment of this type of renal cyst.

Aged↗