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Biomedical subjects

L Simionescu

Publications and source records attributed to L Simionescu.

At least 19 recordsLinked to original sources
PubMed2001

Hormonal and metabolic response in elite female gymnasts undergoing strenuous training and supplementation with SUPRO Brand Isolated Soy Protein.

BACKGROUND: This study evaluates the metabolic and hormonal response in elite female gymnasts undergoing strenuous training and supplementation with SUPRO Brand Isolated Soy Protein. METHODS. EXPERIMENTAL DESIGN: 14 top female gymnasts (Romanian Olympic Team), took part in a study to examine their hormonal metabolic profile and to investigate any possible changes resulting from a 4-month program of strenuous training and daily supplementation with soy protein at a level of 1 g/kg body weight. Gymnasts wtare randomly assigned to one of two groups seven to the Supplemented Group (A) and seven to the Non-Supplemented Group (B). Both groups took part in the same program, which consisted of strenuous training for 4-6 hours/day (except on Sunday, controlled food intake and supplements including vitamins and minerals. Group A received a supplement of Sports Beverage Protein Mix with SUPRO Isolated Soy Protein (ISP) twice daily. Group B received a placebo identical in appearance and flavour. Selected parameters were measured before and after the 4-month training program (lean body mass, fat mass, serum hemoglobin, protein, fats, urea and creatinine, liver enzymes, serum total calcium and magnesium, immunoglobulins, urinary mucoproteins, serum T3 and T4, estradiol, progesterone, prolactin, testosterone and urinary 17-ketosteroids). RESULTS: Results demonstrated that the Supplemented Group (A) had an increase in lean body mass and serum levels of prolactin (p < 0.01) and T4 and a decrease in serum alkaline phosphetases (p < 0.01). The Non-Supplemented Group (B) had a decreased level of serum T4 and an increased level of urinary mucoproteins (p < 0.05). CONCLUSIONS: Our preliminary conclusions might suggest lower metabolic-hormonal stress in elite female gymnasts undergoing strenuous training and who received daily supplementation with isolated soy protein.

Adolescent↗
PubMed1996

Sandostatin LAR: a promising therapeutic tool in the management of acromegalic patients.

A stable and sustained suppression of growth hormone (GH) secretion was noted in 101 patients treated long term with individual doses (20 and 30 mg in 89 patients, 40 mg in 12 patients) of Sandostatin LAR (Sandoz Pharma Ltd, Basel, Switzerland). Doses of 20 mg and 30 mg at 4-week intervals delivered average octreotide concentrations of 1,348 +/- 483 ng/L and 2,631 +/- 1,026 ng/L, respectively, in steady-state conditions and provided adequate control of patients who had been well controlled during treatment with 0.1 mg and 0.2 mg thrice-daily subcutaneous (SC) Sandostatin. Suppression of GH serum concentrations to less than 5 micrograms, 2 micrograms, and even 1 microgram/L was recorded in more patients and more consistently during long-term treatment with Sandostatin LAR than Sandostatin. A marked decrease or even a normalization of insulin-like growth factor-1 (IGF-1) serum concentrations was observed after the first double-blind 10-, 20-, or 30-mg dose of Sandostatin LAR. A progressive improvement was recorded during long-term treatment, with normalization of IGF-1 serum concentrations in 65.3% of patients. A marked clinical improvement was observed in parallel, with 36 of 101 patients (35.6%) becoming asymptomatic after the nineteenth injection of Sandostatin LAR. A greater than 20% shrinkage of the GH-secreting adenoma was also recorded in 12 of 14 patients treated with Sandostatin LAR after receiving only 2 to 4 weeks of treatment with SC Sandostatin and in 11 of 18 patients receiving Sandostatin LAR as adjuvant therapy after failure of surgery. The systemic tolerability of Sandostatin LAR was good, and most adverse events were mild and short term (1 to 2 days). No impairment of thyroid function was detected. Newly occurring gallstones were recorded in four of 101 patients and microlithiasis in four of 101 after up to 30 months of treatment with Sandostatin LAR. Due to its excellent efficacy, good tolerability, convenience of administration, and acceptability by patients, Sandostatin LAR is considered a promising therapeutic tool in the management of acromegalic patients.

Acromegaly↗
PubMed1986

Late hypothyroidism following subacute thyroiditis.

The authors followed up the incidence of permanent hypothyroidism in 35 patients with subacute thyroiditis (SAT) in their past history. The investigations were made one to four years after the acute episode. Ten of these presented repeated recurrences despite the therapy with glucocorticoids. The investigations included serum determination by RIA of T4, T3, TSH and thyroglobulin as well as of circulating thyroid antibodies. Permanent hypothyroidism subsequent to SAT occurred in two patients. In one of them it occurred following thyroid surgery performed for repeated recurrences. Both patients presented high levels of circulating thyroglobulin antibodies suggesting a possible transition to autoimmune thyroiditis. In the authors' opinion permanent hypothyroidism is likely to develop after SAT only in association with an autoimmune process or after thyroid surgery.

Adult↗
PubMed1985

Differential effects of some predominantly antiadrenergic and antidopaminergic neuroleptics on the preovulatory surge of FSH, LH and prolactin in rat.

In experiments performed on rats, single subcutaneous doses of predominantly antiadrenergic neuroleptics (thioridazine, propericiazine) significantly depressed the preovulatory serum LH surge. On the contrary, predominantly antidopaminergic drugs (pimozide and in lesser extent thiethylperazine) elevated the circulating LH levels, and reduced pituitary LH content. FSH titers were not altered significantly (excepting by thioridazine). All the neuroleptics increased serum prolactin. The present results, in conjunction with our previous data obtained on the estrous cycle, suggest a stimulatory role of norepinephrine/epinephrine in LH-RH secretion and an inhibitory action of dopamine on the same process. In our experiments only the predominantly antidopaminergic drugs had a pseudopregnancy-inducing effect, which not only elevated PRL levels, but also allowed (rather increased) preovulatory LH surge, and the subsequent development of new corpora lutea. The lack of pseudopregnancy after predominantly antiadrenergic neuroleptics may be attributed mainly to their antiovulatory action preventing the development of fresh corpora lutea.

Animals↗
PubMed1984

Disappearance rate of insulin antibodies after discontinuing insulin treatment in 42 type 2 (non-insulin-dependent) diabetic patients.

The disappearance rate of insulin antibodies was studied after cessation of insulin treatment which had been given for 3 months to 6 years in 42 Type 2 (non-insulin-dependent) diabetic patients. Insulin antibodies were measured before and 15 days after interruption of insulin treatment, and every 30 days until the disappearance of insulin antibodies. The mean +/- SD value of insulin binding in the entire group before the interruption of insulin treatment was 32 +/- 14%. There was no relationship between the antibody level at that time and the duration of insulin treatment. However, the insulin antibody level was significantly higher in 17 diabetic patients on an insulin dose of greater than 20 U/day (p less than 0.02) than in 25 on an insulin dose of less than 20 U/day (39 +/- 13% versus 28 +/- 12%). A positive correlation was found between initial insulin binding and the time required for it to fall below 10% (r = 0.74). Antibodies were absent 60 days after discontinuing insulin treatment in eight of ten subjects presenting with initial binding of less than 20%. In contrast, in only two of 12 patients with an initial binding of greater than 40% were insulin antibodies detectable 150 days after discontinuation of insulin therapy. Disappearance of insulin antibodies sometimes took up to 1 year and occasionally even more than 2 years.

Aged↗
PubMed1982

Gonadotropins in rats with hereditary diabetes insipidus (Brattleboro strain).

In the Brattleboro strain of rats, the genetic defect in vasopressin synthesis seems to be accompanied by a defect in the synthesis of other structurally related nonapeptides, such as the pineal arginine vasotocin which has antigonadotropic properties in animals. It was therefore tempting to investigate gonadotropin secretion in rats with hereditary hypothalamic diabetes insipidus (DI rats).

Animals↗
PubMed1979

The treatment with 2-brom-alfa ergocriptine in the syndrome amenorrhea-galactorrhea.

In this study, the authors present the results obtained in thirteen cases with amenorrhea-galactorrhea treated with 2-brom-alfa-ergocriptine in which the menstruation has reoccurred in eleven patients, three of them becoming pregnant. The authors have accurately described the evolution of the three pregnancies, which were delivered at term and the children born were normal. The present study was elaborated in the Sterility Department of the Clinic of Obstetrics and Gynecology "Giulesti", University School of Medicine, Bucharest. The study refers to the use of 2-brom-alfa-ergocriptine (Parlodel-Sandoz) in the treatment of the amenorrhea-galactorrhea syndrome associated with sterility.

Adult↗
PubMed1977

[Luteotropic hormone (LTH) level in men with alcoholism].

The authors examined 46 male patients with alcoholic disease and 10 healthy ones, aged from 20 to 50. The LTH dosing is performed by radioimmunologic method with double antibodies. A significant LTH decrease was found in the alcoholic male patients, as compared with the healthy control ones, convincingly speaking of the LTH affection in chronic alcoholism. The absence of discrepancy in LTH level in patients with and without sexual disorders gave grounds to the authors to persume that that hormone has not a definite participation in the sexual disturbances origination in alcoholism.

Adult↗
PubMed1976

Clinical use of glycine intravenous load for diagnosis of growth hormone deficiency.

Intravenous glycine injection (250 mg/kg of body weight) resulted in growth hormone release in normal children but not in those with growth hormone deficiency diagnosed by insulin-induced hypoglycaemia. In the latter significantly higher peak concentrations of serum alpha-amino nitrogen were also found. False negative responses to glycine (no GH release) were observed in two patients of short stature but normal pituitary function. In them the peak levels of serum alpha-amino nitrogen were lower than in those with hypopituitarism. We propose the clinical use of glycine as an inexpensive and innocuous procedure for the detection of GH deficiency in children. A post-glycine GH peak greater than 10-0 mu/l seems to be a good index of an intact GH reserve.

Blood Glucose↗
PubMed1975

Modified technique of perfusion of isolated rat pancreas tested by insulin release after glucose administration.

A method of in vitro perfusion of isolated rat pancreas in a closed circuit is presented. The surgical procedure was slightly modified as compared to the methods published by others the superior mesenteric and coeliac arteries being fixed with tubings for the arterial inflow and the portal vein for the venous outflow. When the attached duodenum is perfused too, it is possible to study both the pancreatic and duodenal excretion. The perfusion of the pancreatic tissue was made with the aid of original equipment. The secretion of insulin into the perfusion fluid after the administration of glucose was measured by radioimmunoassay and a rapid increase of insulin level was found. This observation together with several histological aspects were considered to show the unimpaired viability of tissue.

Animals↗