[Research on growth factors in vitro: action of glutamine and glucose on epithelial and fibroblast strains maintained with serum percolated on Sephadex].
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Biomedical subjects
Publications and source records attributed to L Simonelli.
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Popliteal artery entrapment syndrome (PAES) is an uncommon pathological entity, caused by segmental popliteal artery compression by the surrounding myofascial structures. Clinical symptoms may appear acutely, with temporary ischaemic attacks, or chronically, with concerned calf claudicatio intermittens and for 30% are bilateral. Diagnosis, besides being based on clinical objectivity (acute and deep pain to the struck limb, mainly during active plantar hyperextension) and history-taking (subject-age and lack of atherosclerosis), is based on ultrasonographic (eco-color Doppler of the aortic-iliac-femural-popliteal trunks, tensiometric Doppler), angio-RM, angio-CT scan and dynamic angiographic exams. Treatment, essentially, is surgical by simple freeing of the popliteal artery from surrounding myofascial structures or by autologous vein (saphenous v.) interposition grafting and patching, or bypass without vessel resection. About clinical case reported by the authors, 44-years female with left calf acute pain symptoms, cold skin by the thermo-touch, hypo-paraesthesia with fifth toe cyanosis and walking inability, surgical treatment, because of precox diagnosis, consisted of simple cut of myofibrous shoot starting from medial head of the left gastrocnemious muscle and compressing popliteal artery, with clinical chart complete resolution.
Large Bowel is not uncommonly involved by extra pelvic endometriosis, however cecal localization is the lowest reported in literature; the differential diagnosis of intestinal endometriosis remains difficult, especially in those patients who underwent surgery in emergency setting. The Authors report a case of cecal endometriosis, operated on the basis of clinical signs of surgical abdomen. At laparotomy macroscopic appearance of the cecal lesion, suggesting a neoplastic mass, induced the equip to perform a right emicolectomy. The Authors discuss the clinical features and the role of surgery in management of extra pelvic endometriosis in emergency setting, in the light of the newest advances in medical treatment.
The authors report two cases of gastrointestinal bleeding in an emergency setting caused by angiodysplasia of colon and small bowel. They stress the rarity of the lesion and consider the difficulties involved in obtaining a preoperative diagnosis. The optimal management is uncertain and depends on the severity and rate of bleeding. A conservative medical approach is indicated for many patients, while surgery constitutes definitive treatment in case of massive hemorrhage or recurrent bleeding. In the cases reported the diagnosis was performed only via intra-operative enteroscopy. An unusual conservative surgical treatment was performed based on ligation of the vascular elements of the angiodysplasia. This method makes it possible to avoid an intestinal resection and yelds good results.
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