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Biomedical subjects

L Singer

Publications and source records attributed to L Singer.

At least 217 records · Page 12Linked to original sources
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Fluoride in treated sewage and in rain and snow.

The liquid effluent of a sewage treatment plan contained 1.21 ppm ionic and total fluoride, which was higher than 1.0 ppm fluoride in the fluoridated public water supply. The discharge of the effluent into a river did not greatly raise the fluoride content of the river water because of dilution and other factors. The semisolid waste of sewage treatment also contained fluoride, but very little was volatilized on burning. Rain and snow were found to contain detectable quantities of fluoride, and the fluoride content of snow increased markedly during exposure to an urban environment.

Fluorides↗
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Fluoride in plaque.

Explore the source record for details and available documents.

Binding Sites↗
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Magnesium in bone mineral: an in vitro study.

The solubility of magnesium in bone mineral from control and magnesium-dificient rats receiving varying fluoride intakes was assessed. Evidence for the existence of a fluoride-related pool of skeletal magnesium possessing a diminished solubility was obtained.

Animals↗
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[Memory disorders in schizophrenia].

The current interest in memory disorders in schizophrenia results from the way perceptions of schizophrenia--whose organic origin is becoming increasingly evident--and memory--according to which there exist not one, but several memories--have developed. Memory disorders in the schizophrenic cannot be considered in isolation from knowledge accumulated in other areas of the cognitive and neuro-sciences; a more detailed understanding of these disorders requires a comparison of the different cognitive approaches, both with each other and with the neurobiological and clinical approaches, so that they can be integrated. Despite numerous methodological and conceptual difficulties, it now appears to have been established that the schizophrenic's memory deficit should be seen in the context of a wider cognitive deficit, that the memory tasks are not all disturbed and that the memory deficit cannot be identified with one specific form of memory. Thus, iconic formation, short-term memory in the traditionally accepted sense and implicit memory are hardly, if at all, affected; in contrast, the early processing of information, working memory and explicit memory are disturbed, probably to the extent that they require the implementation of strategies to organise the information to be memorized. Finally, in certain tasks, such as those evaluating latent inhibition or negative priming, schizophrenics perform better than normal subjects, suggesting that schizophrenics' cognitive deficit is localised. This profile of memory disorders is compatible with a dysfunction predominating in the frontal and temporo-hippocampal regions. Neuroleptics and anticholinergics have opposite effects on cognitive and mnesic performance, which is improved by the former and aggravated by the latter. The influence of clinical symptoms, positive or negative, institutionalisation of patients and chronic tardive dyskinesia is unclear. Among the theoretical proposals put forward to account for the observed disorders, those relating to a disturbance of the action planning process and to that of the internal representation of context are compatible with the observed memory disorders. All the clinically derived data and those produced by the cognitive and neurosciences indicate a need to reformulate the links between memory, selective attention and evaluation of the relevance of a stimulus, to develop a general model of the reciprocal interactions between cognition and affectivity and to look for the origin of a pathology as complex as schizophrenia, not in a local lesion in an isolated cerebral structure but in a disturbance of the dynamic interactions within a functional, parallel and distributed network of broadly interconnected regions.

Antipsychotic Agents↗
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Operative treatment of Brodie's abscess.

This manuscript deals with a unique operative management of unilateral Brodie's abscess in a 16-year-old male. Brodie's abscess is a common finding in childhood osteomyelitis. A review of the radiographic appearance, clinical presentation, and surgical management is presented.

Abscess↗
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[Rehabilitation of patients with schizophrenia].

Follow-up of 17 schizophrenic patients on long- or very long-term treatment (3 to 27 years), sectorial follow-up of a group of 57 schizophrenics since 1984 and 24 new patients since 1988, study on the development of 50 schizophrenics followed in an out-patient treatment centre and who had left this centre since 1987, are reported. The authors present their findings on their patients' socio-professional insertion or re-insertion. Thanks to progress in therapy, the long-term follow-up of schizophrenic out-patients is now possible. Complete hospitalisation can be avoided or its duration generally reduced. Socio-professional insertion or re-insertion depends on a certain number of factors affecting the observance by the patient and the regular following of his treatment. These factors and the evolution of the disorders are often unforeseeable, and render the patient's re-insertion problematical. The quality of the re-insertion also depends on the care possibilities available to the patient: sectorial follow-up, job-aid centre, sheltered workshops, associative apartments, leisure. Whatever the case, professional insertion seems much more limited than social insertion. Professional life can however be envisaged in subordinate work or in a sheltered working environment where the schizophrenic feels safe within a definite, fixed architectural and affective frame of reference.

Adult↗
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Preclinical development and characterization of an intravenous dosage form for the ACE inhibitor RS-10029.

Preclinical development of an intravenous dosage form for the ACE inhibitor RS-10029 involved the formulation and characterization of the drug's chemical/physical stability in two prototype formulations (injectable solution and lyophilized powder). Included in these studies were quantitative evaluations of various processing and administration parameters (membrane qualification, terminal sterilization, compatibility/delivery of the drug with typical infusion fluids and administration sets) on finished product integrity and quality. Analytical methodology used in these studies consisted primarily of a stability specific HPLC assay and a light obscuration based sensor (HIAC) for particulate matter analysis. Results of these studies indicate that the drug is relatively stable at ambient temperature and under accelerated storage conditions (predicted T90 at 25 degrees C greater than 2 yr, and T90 at 50 degrees C greater than 2 mo). However, the ability of the product to withstand a full terminal sterilization cycle is limited, and therefore other approaches toward sterile processing were examined. With regard to the stability and compatibility of the drug in a variety of fluids and devices there appears to be no overt limitations in its use for either bolus or infusion delivery.

Angiotensin-Converting Enzyme Inhibitors↗