The histogenesis of appendiceal carcinoid tumours.
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Biomedical subjects
Publications and source records attributed to L Sobin.
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Although considerable resources are being allocated globally to cancer research, efforts to implement these findings efficiently are lagging behind. Enough is known about the cause of common tumors such as lung, oral, and liver cancer to allow active measures to be taken for their prevention. Effective early detection programs have been developed for cervical, breast, and oral cancer, and treatment methods exist whereby at least one-third of all cancer patients can be cured if their disease is detected early. Unfortunately, however, most cancer activities currently in place were developed haphazardly and lack overall coordination. National cancer control efforts can be more effectively planned and implemented if they follow a systematic stepwise approach of assessing the current situation, setting health objectives, evaluating the possible strategies, and setting priorities using quantitative assessments. Cancer affects both developed and developing countries of the world, and well planned national efforts emphasizing prevention and early detection can significantly reduce the cancer problem.
Less than 1% of the lung cancer cases from the Surveillance, Epidemiology, and End Results (SEER) Program changed categories as a result of the World Health Organization's revision of histologic classifications of lung tumors. Of the 28,119 microscopically proved lung cancers reported to SEER in 1977-79, 32% were squamous cell carcinoma, 16% were small cell and/or oat cell carcinoma, 27% were adenocarcinoma, 8% were large cell carcinoma, and 5% were other specified types. A further 12% (approximately 3,500 cases) were reported with such nonspecific terms as bronchogenic carcinoma, carcinoma of the lung, and undifferentiated or anaplastic carcinoma. The magnitude of the use of these nonspecific terms showed the need for greater precision in reporting and recording data.
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This memorandum proposes a standardized system of reporting the histology of human lymph nodes based on commonly used simple staining techniques. The purpose is to provide a uniform, internationally acceptable system by which the histological structure of lymph nodes can be correlated with other parameters of immunological status. The proposed protocols are intended to provide information that is not available in conventional written reports that use such terms as ;hyperplasia' or ;nonspecific lymphadenitis'.
This Memorandum proposes a standardized system of reporting the histology of human lymph nodes based on commonly used simple staining techniques. The purpose is to provide a uniform, internationally acceptable system by which the histological structure of lymph nodes can be correlated with other parameters of immunological status. The proposed protocols are intended to provide information that is not available in conventional written reports, that use such terms as "hyperplasia" or "nonspecific lymphadenitis".
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