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Biomedical subjects

L Soifer

Publications and source records attributed to L Soifer.

10 recordsLinked to original sources
PubMed1995

[Multicenter study for the evaluation of the reproducibility in the measurement of rectal sensorial threshold].

A simple way to evaluate the rectal sensorial threshold has been the sloped distention of a rectal balloon, as a way to obtain the required volume to induce desire to defecate (VDE) and pain (VTM). Six medical groups belonging to the Argentine Motility Circle, studied in 14 patients (7M, 7F age 51 +/- 10.1) the VDE and VTM. The measurements were repeated in the same subjects with intervals longer than 24 Hs. The estimate of precision established a coefficient of variation (CV) for VDE of 10.23% (2CV = 20.46%). And so Reproducibility was found to be not acceptable. The CV for VMT was 1.44 (2CV = 2.88%) this could be considered a very good reproducibility. In conclusion, the VTM appears to be a reproducible measurement suitable for clinical and pharmacological studies of the rectal sensorial perception.

Adult↗
PubMed1994

[Do the physical characteristics of radiopaque markers modify the results of the measurement of colonic transit time?].

UNLABELLED: This study was performed in 15 healthy control subjects (8 males- age 23-70 and 7 females age 20-74) as a way to compare the total and segmental colonic transit time with two different type of radiopaque markers. One type of markers was 3 mm cut sections of a radiopaque polietilene 14 French Levine tube, with a medium weight of 64.3 mg and a specific gravity (SG) of 1.28. The other type were 7 mm lenticular insoluble barium (lentils) with medium weight of 231 mg and a SG of 1.87. Each subject ingested 20 markers of each type with the breakfast and front and profile plain films of the abdomen were taken 24 and 48 hs after. The total colonic transit time for the polietilene markers was 17.7 hs and 27.3 hs for the barium type (BM) (p < 0.001). The segmental transit time for right colon was 2.4 hs (PM) and 9.7 hs (PM) and 9.7 hs (BM) (p < 0.001) in the left colon 9.5 hs (PM) and 11.3 hs (BM) and in rectoanun 5.9 hs (BM) with no statistical significance. CONCLUSION: the physical characteristics of the radiopaque markers can modify the results of the colonic transit times.

Adult↗
PubMed1993

[pH-metric variables in gastroesophageal reflux in asthmatic patients].

As there is an increased incidence of gastroesophageal reflux (GER) in asthmatic patients compared with the normal population, in the present trial we have tried to establish the following: 1) Possible differences in pH-metric variables between patients with GER and asthma, and asthmatic patients with or without GER 2) The usefulness of simultaneous evaluation and correlation of reflux episodes with the respiratory peak flow (EPF) in asthmatic patients. 31 patients divided in four groups were compared. A) 16 patients with typical symptoms of GER without respiratory symptoms. B) 10 asthmatic patients with GER symptoms. C) 5 asthmatic patients without GER symptoms. D) 15 asthmatic patients who represents the sum of B and C. In all patients ambulatory computerized, four hours pH recordings were obtained after standard meal. The study was divided in two equal periods (upright and recumbent). The EPF was measured before starting the study and every 20 min during the recumbent period. From de following pH-metrics variables: total number of reflux episodes, percentage of recording time when intra-oesophageal pH < 4 in the upright position or recumbent position and for the total period, duration of longest reflux episode, number of episodes longer than five minutes, and correlation between reflux episodes and patients symptoms. Only differences were seen when the time of the longer period with GER and the number of patients with more than five minutes episodes were compared between groups A and D. From the results we conclude that the GER in asthmatic patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Asthma↗
PubMed1992

[Manometric effects of pinaverium bromide in irritable bowel syndrome].

The effects of pinaverium bromide on colonic motility were investigated in a controlled, controlled, cross-over study in 32 patients with irritable bowel syndrome. Constipation was clearly predominant in one group of 16 patients, and diarrhea in the other group of 16. Manometric measurements were taken of the colonic motor response generated by distention of a balloon inserted to the rectosigmoid junction. Measurements were taken before and one hour after ingestion of two tablets containing placebo or two tablets each containing 50 mg of pinaverium bromide. Following intake of placebo the motility index increased from the basal value in patients with constipation, and resistance to distention decreased in the diarrhea group. These changes were attributable to repetition of the mechanical stimulus within a relatively brief time lapse, or more probably to the ingestion of liquid which accompanied intake of tablets. Compared with placebo, pinaverium bromide induced inhibition of both effects. From the therapeutic point of view, the decrease in motility index seen in patients with irritable bowel syndrome and constipation is particularly interesting.

Adult↗
PubMed1989

[Somatostatin in the emergency treatment of upper digestive hemorrhage in patients with portal hypertension].

During a 2-yr period 15 patients (17 episodes) with variceal bleeding (VB) and 7 with cirrhosis and acute gastroduodenal haemorrhage (GDH) received intravenous somatostatin (250 mcg per hr after a bolus of 250 mcg). Initial control of bleeding was achieved in 13 (76%) with VB and in all with GDH. Three of the 4 patients with VB and 2 with GDH who rebled during treatment were controlled increasing the infusion to 500 mcg/hr. Patients with VB received somatostatin for 24 hrs, time selected for initiating injection sclerotherapy, and those with GDH for 48-72 hrs. At 24 hrs 71% of patients with VB and all with GDH were free of bleeding. Combining different therapies VB was controlled in 16 of the 17 episodes (94%) with only one death. No complications were observed in any of the 22 patients treated.

Adult↗
PubMed1982

[Fiberendoscopic sclerotherapy of esophageal varices: relationship of varices size, quantity of sclerosing agent used and number of sessions].

By means of fiberendoscopic injection sclerotherapy, it was possible to achieve eradication of esophageal varices in 18 patients. At the onset of treatment 9 patients had small varices (grade II) and other 9 had big varices (grade III). It was found in the big varices group there was needed more courses (p less than 0.01) and a greater amount of sclerosing agent (p less than 0.001) than in the group with small varices. Since those patients with big varices required more courses and more volume of sclerosing agent, and in fact they have more risk to rebleed during the pre-eradication period. It is proposed as a solution during this period, the use of a B receptor blocking agent (Propranolol) simultaneously with sclerotherapy.

Adult↗
PubMed1980

[Fiberendoscopic sclerotherapy of esophageal varices (description of a technic)].

We describe a technique used for fiberendoscopic sclerosis of esophageal varices. The addition of a balloon around the endoscope is advocated for three uses: 1) ingurgitation of varices allows better visualization, 2) the methods avoid the quick clearing of the sclerosing agent, 3) it can be used as hemostatic agent in case of necessity. The sclerosant agent used is an association of ethanolamine oleate, hypertonic glucose solution (50%) and natural conjugated strogens.

Esophageal and Gastric Varices↗