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Biomedical subjects

L Sorel

Publications and source records attributed to L Sorel.

44 records · Page 3Linked to original sources
PubMedDate not supplied

[Benign grand mal epilepsy in the adult].

In two separate papers submitted to a symposium in Barcelona in December 1987 on primary, generalized grand mal epilepsy becoming manifest in adulthood, the findings were so identical that the authors thought it appropriate to make a joint publication. L. Oller Daurella, after studying 90 cases, and L. Sorel, after studying 80 cases, propose the definition of a particular form of benign grand mal epilepsy in the adult. The various characteristics of this new entity are described.

Adult↗
PubMedDate not supplied

Diclofenamide in the treatment of therapy-resistant epilepsy.

An average daily dose of 33 mg of diclofenamide, a carbonic-anhydrase inhibitor, was added to the anti-epileptic medication already employed in 105 cases of severe epilepsy which had shown insufficient clinical improvement. A favourable action on seizures, often accompanied by an improvement in the EEG tracing, was observed in 83 cases. The effect was of long duration in 47 cases in that it lasted for more than a year. It persisted for one to twelve months in a further 17 cases, while in 19 patients, who had reacted favourably to the treatment, medication had to be suspended because of intolerance.

Adolescent↗
PubMedDate not supplied

[Flunarizine in epilepsy. Evaluation of a 4-month supplementary treatment in patients resistant to treatment with existing antiepileptics].

Twenty patients affected with a form of epilepsy resistant to treatment received 10 to 20 mg of flunarizine per day in addition to the anti-epileptic medication. The majority of the patients suffered from partial epilepsy with or without secondary generalization. The flunarizine treatment was evaluated after four months. On the whole, flunarizine was well tolerated. The number of attacks was reduced by 50% or more in half the patients.

Adult↗
PubMedDate not supplied

[Comparative study of valproic acid and sodium valproate (author's transl)].

The action of valproic acid prescribed instead of sodium valproate in strictly identical conditions was analysed in 11 epileptic children and 24 adults. No change in therapeutic effect was observed in a large proportion of cases. However, blood tests showed an increase in serum levels in most cases. Thus, valproic acid can be of help in cases hitherto treated with sodium valproate, on the same basis as diphenylhydantoin; the acid form sometimes offers an advantage over the use of the sodium salt.

Adolescent↗
PubMedDate not supplied

[Computerized axial tomography and epileptic entities (author's transl)].

On the basis of a personal classification, the authors attempt to establish a correlation between the CAT scan and various forms of epilepsy. Although some results are entirely consistent, the authors find that in a fair number of apparently lesional forms of epilepsy the CAT detects approximately the same percentage of abnormalities in cases with a history of clear pathological antecedents as in those without such antecedents. In the light of this finding, the relation between the CAT record and the true cause of epilepsy is reconsidered.

Adolescent↗
PubMedDate not supplied

[Electroencephalogram and CAT scan in 393 cases of epilepsy. Consistency between focal EEG changes and focal CAT changes (author's transl)].

A simultaneous study of EEG recordings and CAT scans in 393 epileptics led to the following findings:--in our population, the EEG pattern is normal in 6.8% of the cases and the CAT normal in 64.6%;--focal EEG changes give focal CAT changes in 38.6% and diffuse changes in 4.1% of the cases;--diffuse EEG changes give focal CAT changes in 18% and diffuse changes in 8.8% of the cases;--focal CAT changes give focal EEG changes in 68% and diffuse changes in 28% of the cases;--diffuse CAT changes give focal EEG changes in 27.5% and diffuse changes in 51.8% of the cases;--out of the 393 epileptics, 72 presented distinctly focal changes on simultaneous EEG and CAT records. The changes were on the same side in 80.5% of the cases. The reasons for the lack of consistency in 19.5% of the cases are discussed.

Brain↗
PubMedDate not supplied

[Comparative study of source leads, bipolar leads and neck reference leads (author's transl)].

A twelve-channel machine was wired up in such a way that the same signals were recorded simultaneously via source leads, longitudinal bipolar leads and reference leads to an electrode at the base of the neck. This comparative study demonstrated that source leads do not provide a more accurate indication of the location of diffuse or extensive cerebral activity. On the contrary, in some cases we noted a decrease in the amplitude of the activities recorded, the suppression of certain components which were none the less present and even the appearance of a recording in phase opposition where there was no inversion of phases in the electrodes concerned.

Brain Diseases↗