Operation and results of a screening program for cancer of the breast.
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Aged↗
Biomedical subjects
L Sperling
Publications and source records attributed to L Sperling.
Mammography as a screening method for the examination of large populations.
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Adult↗
Lipids of ocular tissues. VII. Positional distribution of the fatty acids in the phospholipids of bovine retina rod outer segments.
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Animals↗
A combined screening program for the detection of carcinoma of the cervix and carcinoma of the breast.
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Adolescent↗
Obstruction of the small intestine.
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Adolescent↗
Management of nonpalpable breast carcinoma discovered by mammography.
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Adult↗
Intubation decompressive therapy in intestinal obstruction.
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Humans↗
Albumin extinction followed by de novo methylation of its gene in somatic hybrids of a rat hepatoma.
We have previously identified an Msp I site at the 5' end of the rat albumin gene whose undermethylation is necessary but not sufficient for stable albumin expression in rat hepatoma cells. We have also shown that the extinction of albumin expression in somatic hybrids is not the result of methylation at this site, since for two different crosses, rapid extinction was found to occur in the absence of any de novo methylation of the previously active gene. In the present study, we examine albumin expression and albumin gene methylation for independent hybrid clones isolated from crosses between albumin expressing rat hepatoma cells and cells of two different non-expressing lines. The cells from hybrid clones of both crosses are characterized by stable extinction of albumin expression. Moreover, we find that de novo methylation of the "extinguished" albumin gene can occur in somatic hybrids, but only some weeks after the gene has ceased to be expressed.
Animals↗