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Biomedical subjects

L Spitz

Publications and source records attributed to L Spitz.

At least 253 records · Page 14Linked to original sources

Obstructive jaundice secondary to chronic midgut volvulus.

A case of progressive extrahepatic biliary obstruction due to chronic midgut volvulus secondary to malrotation in a 5-month-old girl is presented. The obstruction to the bile duct was relieved after correction of the malrotation and division of the obstructing bands.

Cholestasis, Extrahepatic↗

Antibodies to poliovirus detected by immunoradiometric assay with a monoclonal antibody.

An immunoradiometric assay (IRMA) for the assay of antibodies to poliovirus antigens is described. Dilutions of the test sera or whole (finger prick) blood samples were incubated with the Poliovirus antigen bound to a solid phase and the specific antibody was detected by the addition of a mouse anti-human IgG monoclonal antibody (McAb), which was itself revealed by iodinated sheep IgG anti-mouse F(ab). We have shown that this technique is suitable for the estimation of IgG anti-poliovirus antibodies induced in children following polio vaccine. The present study shows that SPRIA provides a simple and inexpensive method for serological studies with poliovirus particularly for use in large-scale surveys.

Antibodies, Monoclonal↗

A comparative study of scalpel and electrosurgical incision on subsequent wound healing.

The mechanical strength of incisions in the anterior abdominal wall using either scalpel or electrocautery was compared by measuring the bursting stresses of the resulting wounds. Statistically significant differences were shown to occur in the first and thirty-fifth postoperative days. Between the seventh and tenth postoperative days, when wound dehiscence is most likely to occur, no difference in the rupture strength could be detected.

Animals↗

Surgical treatment of gastrooesophageal reflux in severely mentally retarded children.

Twenty severely mentally retarded children with significant gastrooesophageal reflux were submitted to surgical treatment. In all patients vomiting was present to a distressing degree in 5 children, 3 of whom required extensive surgery to overcome the obstruction. All had failed to respond to conservative measures. Although the postoperative complication rate was high (50%), the final result in the majority of patients was highly satisfactory.

Adolescent↗

Combined esophageal and duodenal atresia: experience of 18 patients.

An analysis of 18 infants with combined esophageal and duodenal atresia is presented. A total of 50 other associated anomalies were identified in the 18 infants. These predominantly involved the genitourinary (11), cardiac (9), anorectal (8), and gastrointestinal (8) systems. There were 6 early survivors (33% survival rate), 1 of whom died later from an unrelated cause. It is suggested that in an otherwise health infant the primary approach should be towards the esophageal atresia and tracheoesophageal fistula. A wide gastrostomy is mandatory. Repair of the duodenal obstruction may safely be postponed for a few days. In the absence of an associated tracheoesophageal fistula, a primary duodenoduodenostomy and gastrostomy with a transanastomotic feeding tube is the approach of choice.

Esophageal Atresia↗

Denial and minimization in telephone contacts with patients.

This paper defines and demonstrates mechanisms of denial, disavowal, and minimization as they operate in telephone contacts between patient or family member and the physician. The physician needs to be cognizant that such mechanisms, operating in both physicians and patients, distort patient's reports of their observations of their illnesses or those of family members. These distorted diagnoses affect proposed treatment plans and ultimate outcome. Examples of situations in which distortions contribute to dangerous consequences are developed in the paper. Specific techniques are elaborated to deal with patients who deny, including expert questioning, direct confrontation, and/or interpretation of the hidden motives leading to the denial. Physicians need to be alert to their own tendency to deny or block out crucial factors secondary to conflicting personal and professional priorities, fear of loss of self-esteem, and unresolved psychological conflicts regarding particular medical syndromes.

Denial, Psychological↗

Intrathoracic foregut cyst (foregut duplication) associated with esophageal atresia.

Intrathoracic foregut duplication cysts are rare congenital foregut malformations that usually produce respiratory symptoms in early infancy. Surgical resection of this anomaly is usually followed by permanent cure. Two cases of intrathoracic foregut duplication cyst associated with esophageal atresia are reported. The first patient had an associated tracheoesophageal fistula while the second had an isolated atresia. Both patients survived following resection of the cysts.

Cysts↗

The detection of auditory visual desynchrony.

Subjects were presented with a film and its soundtrack through apparatus which enabled asynchrony between picture and sound to be increased. It was found that asynchrony is more easily detected when sound precedes picture, and for a hammer hitting a peg than for someone speaking. These preliminary results suggest that we learn to tolerate the asynchrony between hearing and vision produced by the slower transmission of sound than of light.

Acoustic Stimulation↗

Phimosis in boys.

Phimosis, defined as scarring of the tip of the prepuce, was studied prospectively in a series of 23 boys aged 4 to 11 years. There was little to support the contention that the condition is caused by trauma, or by ammoniacal or bacterial inflammation of the prepuce, nor could any other aetiological factor be identified. Histological examination of the foreskin showed the appearances of Balanitis Xerotica Obliterans in 20 of 21 specimens submitted for study.

Balanitis↗

Primary vesicoureteric reflux in neonates with imperforate anus.

Cystography, performed in 26 out of a total of 33 consecutive neonates with imperforate anus, revealed primary vesicoureteric reflux in 12 cases. The reflux was usually pronounced, and was particularly common in females and in infants with urinary tract infections. The incidence of reflux was unrelated to the severity of the anorectal anomaly, and reflux was often demonstrated in patients in whom an intravenous pyelogram had shown an undilated upper renal tract.

Anus, Imperforate↗

Ligation of the common bile duct in the fetal lamb: an experimental model for the study of biliary atresia.

Intrauterine ligation of the common bile duct was carried out in ten fetal lambs at approximately 80 days gestational age. Six of the fetal lambs survived until term and were sacrificed at varying periods until the 36th day of life. The lesion which developed resembled a "correctable" type of extrahepatic biliary atresia [Kasai type I (b)]. The lining epithelium was either totally or incompletely denuded in the blind end of the common duct proximal to the obstruction.

Animals↗