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Biomedical subjects

L Stankler

Publications and source records attributed to L Stankler.

At least 19 recordsLinked to original sources
PubMed1992

Atrophoderma of Pasini and Pierini. An immunopathologic case study.

Atrophoderma of Pasini and Pierini (APP) is a rare and distinctive form of dermal atrophy of uncertain origin. In only one previous report have immunopathologic methods been used to study a case of atrophoderma of Pasini and Pierini, and on the basis of the results obtained it was concluded that immunologic mechanisms were relevant to the pathogenesis of the condition. A detailed investigation of a case of atrophoderma of Pasini and Pierini was conducted using immunofluorescence and immunoperoxidase techniques. The epidermal Langerhans cells were abundant and expressed polyclonal immunoglobulin M on the cell-surface membrane. Biopsy of the same lesion was repeated 6 months later and revealed staining for immunoglobulins A and M and also for C3. This pattern of staining could not be reproduced in a range of other atrophic or scarring cutaneous lesions. Immunophenotypic analysis of the mild perivascular mononuclear cell infiltrate revealed an aberrant T-cell phenotype of uncertain significance.

Adult↗
PubMed1991

Breast vasculitis in association with breast gigantism in a pregnant patient with systemic lupus erythematosus.

A 24 year old woman with systemic lupus erythematosus (SLE) developed widespread necrotic skin ulceration and gigantism of both breasts during an exacerbation of SLE in the last trimester of her second pregnancy. Over the remainder of the pregnancy the ulceration was only controlled by high dose corticosteroids. After parturition, however, it was possible to reduce the steroid dose without recurrence of the ulceration.

Adult↗
PubMed1988

Zinc deficiency: specific scalp hair defects seen by scanning electron microscopy may provide a valuable new test.

Zinc deficiency in man results in multisystem disease. It may be acquired or hereditary; the latter can be fatal if left untreated. Premature babies are particularly susceptible to zinc deficiency. Unfortunately no simple, reliable test for zinc status exists at present. Short, newly-emerging scalp hair samples from 3 classical cases of zinc deficiency all showed the same characteristic abnormalities when examined by scanning electron microscopy, i.e. straight, blunt tips bearing scales, unusually thick cuticular scales with jagged free-edges, and very fine longitudinal corrugations in individual scales. These abnormal features occurring together appear to be specific for zinc deficiency; they also varied in severity with marked variations in zinc status during follow-up studies. Due to the relative rarity of classic cases of zinc deficiency, it is not possible for one centre of our catchment size to conduct a preplanned study. However, if the present findings can be confirmed elsewhere, it is concluded that scanning electron microscopy of appropriately-selected hairs may provide a valuable new test for the diagnosis of zinc deficiency and for monitoring the response to zinc therapy.

Child, Preschool↗
PubMed1984

Prominent fungiform papillae in guttate psoriasis.

Three patients presented with widespread guttate psoriasis of explosive onset which involved the palms and soles (exanthematic guttate psoriasis) and followed, in each case, a haemolytic streptococcal throat infection. At the height of the effluorescence the lingual fungiform papillae were very numerous, red and prominent and their subsequent course paralleled that of the skin lesions. This oral finding has not been reported previously in patients with psoriasis.

Adolescent↗
PubMed1982

Unexplained diarrhoea and failure to thrive in 2 siblings with unusual facies and abnormal scalp hair shafts: a new syndrome.

A family is described in which 2 siblings born to healthy parents presented with abnormal facies, persistent diarrhoea, and early death. Exhaustive pathological and biochemical investigations failed to find a cause. The scalp hair of both babies had an abnormal amino-acid composition, and presented an appearance that was unique on scanning electron microscopical examination; this fact and the clinical picture probably represents a new syndrome.

Amino Acids↗
PubMed1981

Follicular psoriasis.

This is a report on ten patients with follicular psoriasis. Two distinct clinical types could be distinguished. An adult form, seen especially in women, presented with widespread psoriasis in which follicular lesions occurred on both thighs as part of the efflorescence. Follicular lesions were aggregated to form isolated asymmetrical plaques on the trunks of children with inactive psoriasis. The histological findings in follicular psoriasis varied according to the age of the lesion. In the early lesion there was a marked dermal infiltrate in which the mast cells were prominent but the hair follicle appeared normal. Older lesions were found to have nucleated cells in the ostium of the follicle. These findings suggest that the hair follicle may be affected as part of psoriatic involvement of the integument.

Adolescent↗