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Biomedical subjects

L Stanton

Publications and source records attributed to L Stanton.

At least 19 recordsLinked to original sources

Screen-film mammographic technique for breast cancer screening.

The values of dose and signal-to-noise ratio (SNR) for many techniques and breast thicknesses were computed and compared with a reference technique and breast thickness to provide a valid basis upon which to select a screening technique for screen-film mammography. The reference consisted of a Min-R/OM1 combination (or its equivalent) exposed through a 4.5-cm thick breast via 28 kV and a molybdenum target-beryllium window tube with a 0.03-mm Mo filter. Radiographs of an improved breast phantom were used to relate computed relative SNR values of techniques to diameters of the smallest calcific and soft-tissue objects demonstrated in mammograms. Without use of a grid, four Mo target/filtration combinations yielded similar computed dose and SNR levels, as did a tungsten target tube operated at 23 kV without a filter. Operation of the latter tube at 27.5 kV with a 0.051-mm rhodium filter should reduce dose by half but also SNR by 22%. However, such operation with a grid should greatly improve imaging moderate to large breasts without increasing dose over reference values.

Breast Neoplasms

Human proto-oncogene N-myc encodes nuclear proteins that bind DNA.

N-myc is a gene whose amplification has been implicated in the genesis of several malignant human tumors. We have identified two proteins with molecular weights of 65,000 and 67,000 encoded by N-myc. The abundance of these proteins in tumor cells was consonant with the extent of amplification of N-myc. The two proteins apparently arose from the same mRNA, were phosphorylated, were exceptionally unstable, were located in the nucleus of cells, and bound to both single- and double-stranded DNA. These properties suggest that the products of N-myc and of the related proto-oncogene c-myc may have similar biochemical functions and that N-myc may be a regulatory gene. Our findings sustain the view that inordinate expression of N-myc may contribute to the genesis of several different human tumors.

Apudoma

Dosage evaluation in mammography.

Estimates of breast dose per view are needed for selection of mammographic techniques and verification of their proper use. However, accurate dosimetry requires standardization of both the methodology and the assumed breast composition. Because several different methods have been reported, the authors developed a simple and reproducible method using a reference "average breast" composition of 50/50% water/fat by weight. Working curves were derived for average glandular and whole-breast dose per unit of exposure in air vs. HVL and thickness. When these curves are combined with on-site measurements of exposure per view, one obtains values of dose per view for each technique. Factors were also computed to correct dosage from the reference composition to other breast compositions.

Adult

Breast radiography: phantom, equipment performance, and radiation dosage comparisons for twenty-eight major mammography centers in the midwest. Work in progress.

This preliminary report discusses mammography tests that were conducted at 28 midwest medical centers. Equipment-parameter measurements were made, and images that were obtained with the Stanton Mark IIR Mammography Phantom were studied to compare image quality. These tests indicate that variations in equipment parameters and techniques can result in differences in the imaging of various sized phantom fibril and speck groups.

Humans

Auditory evoked potentials and auditory behavior following prenatal and perinatal asphyxia in rhesus monkeys.

Two types of asphyxia were studied in monkeys, total asphyxia during mid-pregnancy (94--98 days gestation) and combined partial and total axphyxia at term (165 days gestation). Auditory evoked potentials and the acquisition of 2 auditory discrimination tasks were studied in asphyxiated animals as well as in group of controls. The brains of all asphyxiates were examined histologically. No auditory discrimination deficit was found in the asphyxiated animals; however, the auditory evoked potentials differentiated between control and asphyxiated animals, especially those with verified inferior colliculus damage.

Animals

Rapid computation of diagnostic X-ray bremsstrahlung spectra.

A method is described for rapid and accurate computation of diagnostic x-ray spectra. Accuracy limitations of Kramers' equation are overcome by providing intensity correction factors derived from published measured data. Use of a parameter based on the energy of the Kramers spectrum intensity peak permits deriving master factor curves which are remarkably independent of kVp, waveform and filtration. Computed and measured spectra generally agree to better than +/- 1 keV for beams generated at 100 kVp and below. Possible application of the method to higher energy diagnostic beams is discussed.

Mathematics

A study of mammographic exposure and detail visibility using three systems: Xerox 125, Min-R, and Xonics XERG.

A breast phantom of novel design has been used to measure visibility of simulated calcific and soft-tissue fibrillar details in mammography, as well as to determine the roentgen exposure vs. depth. Exposure data were combined with a model of the breast as compressed during mammography to compute the mean exposure to the ductal parenchyma (MDE). Three different imaging systems were compared over a wide range of x-ray beam energies and breast characteristics. "Dosage" criteria other than the MDE are discussed.

Breast

Clinical evaluation of electron radiography. Current status.

Details of a 4-phase evaluation of electron radiography are reported. The experimental equipment now uses liquid toners which result in less edge contrast and latitude than in powder-cloud exposures. Use of a bias technique during development prevents deposition except to areas where voltage exceeds the bias voltage. Quality radiographs with decreased doses and expense result.

Electrons

Image characteristics of liquid developed electron radiographs.

This paper presents electron radiograph studies using the new Xonics liquid development system described only briefly previously. Results indicate: (a) higher contrast images with reduced but useful edge enhancement; (b) adjustable contrast; (c) reduced exposure vs. aerosol development; (d) sharp, low artifact images to densities greater than 2.5; and (e) possibility of nongrid scatter control in some situations.

Electrons

Racial differences in color vision: do they exist?

The present experiment investigated the possibility that variation in fundus pigmentation among individuals may be related to differential color sensitivity. Fifty black and white observers representing a wide range of skin (and fundus) pigmentation made direct heterochromatic brightness matches for a white standard field against each of five chromatic comparison fields. Results indicated that pigment (i.e., racial) differences in color vision do not exist, as measured by the two psychophysical methods used. The data showed that the heterochromatic matches were less reliable for the more saturated colors, violet and red, and also that the psychophysical methods used to obtain the matching data differentially influenced the results for the more saturated colors.

Black People