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Biomedical subjects

L Stefanović

Publications and source records attributed to L Stefanović.

17 recordsLinked to original sources
PubMed1995

[Use and efficacy of radioiodine therapy in the treatment of hyperthyroidism].

Radioiodine (131J) therapy is a method of radical treatment for hyperthyroidism. In our study in the period 1971-1993, we administered radioiodine therapy in 163 patients with hyperthyroidism. We performed a long-term follow-up, from one month, to 21 years after the radioiodine therapy. The cured rate was 83.4%: euthyroid state was found in 43.6% of patients and hypothyroidism appeared in 39.9% of patients. After the radioiodine therapy hyperthyroidism was found in 16.6% of cases. Radioiodine therapy is very efficient, non-invasive, radical treatment of hyperthyroidism, not expensive and easy to administer. It has practically no immediate or long-term complications, except hypothyroidism.

Adult↗
PubMed1993

[Scintigraphy of the vascular supply of the liver in the differential diagnosis of hemangioma, in malignant processes and cystic formations in the liver].

The aim of the research is to establish and confirm the diagnoses of patients with suspected haemangioma of the liver with completed ultrasonography. A group of 92 patients were checked by scintigraphy after the equilibration of marked eritrocytes in the circulation. After the marking dose of 99mTc-Sn-PYP in a dose of 555 MBq scintigraphy and static scintigram of the liver (early and late, after 3 hours) were done. During the clinical studies the classic scintigraphy of the liver by 99mTc-S-coloid was done in all the patients. After the study it was concluded that there was a partial gathering of the radioisotopes in early scintigrams which was more evident in the late ones especially in the areas which represented focal-cold zones in the classic scintigrams.

Adult↗
PubMed1993

Myocardial perfusion imaging using 99mTc-MIBI in patients with dilated cardiomyopathy--methodology and its clinical use.

The aim of the study was to demonstrate the methodology of investigation of myocardial perfusion and viability using 99mTc-MIBI in patients with dilated cardiomyopathy and to estimate its clinical use. Myocardial perfusion and viability were investigated by using the planar and SPECT scintigraphy and by estimating the wall motion of the myocardium. The foci of decreased myocardial viability were found in 7 patients. One patient had perfusion defect only at stress. Analyzing the patients data, by using the gated studies, we found various degrees of wall motion myocardial abnormalities.

Cardiomyopathy, Dilated↗
PubMed1993

Correlation between the blood pool tomoscintigraphy (SPECT) and planar scintigraphy in the diagnostic of the liver hemangioma.

The aim of the study was the estimation of diagnostic importance of the hepatic blood pool tomoscintigraphy (SPECT) and planar scintigraphy in patients investigated under suspicion of the liver hemangioma. In the diagnostic procedure the correlation between radiocolloidal scintigraphy, blood pool planar scintigraphy (early and late) and SPECT was made. Sixty-seven patients with focal lesions in the liver were investigated. The blood pool scintigraphy was made after application of traser dose of 99mTc and equilibration of tagged red blood cells in circulation. The planar scintigraphy was made 20 min after the red cells tagging and again 2 hours later (early and late scintigrams). SPECT was also applied to make the diagnostic procedure more accurate. From 31 hemangiomas detected by SPECT only 19.4% were clearly visible by planar scintigraphy. The diagnostic of very small hemangiomas is enabled by SPECT too.

Adult↗
PubMed1993

Protocol of the diagnostic, therapy and follow-up of differentiated thyroid cancer.

The Protocol of the multidisciplinary diagnostic treatment and follow-up of differentiated thyroid cancers, made in the Institute of Oncology in Sremska Kamenica, is described. It is in use in this institution from 1990. It is in concordance with general oncology principles and follows the guidelines of the International Union Against Cancer (UICC) concerning this problem.

Clinical Protocols↗
PubMed1992

[Dosimetric measurements and early complications in patients with differentiated thyroid carcinomas treated with radioactive iodine].

The aim of the study was to determine the exposure dose rate during the application of radioiodine therapy (ablative or tumoral dose) given in order to treat the differentiated thyroid carcinoma, during the medical visit and examinations of those patients, to establish the safety distance from patients both for population and for medical staff and to perceive early complications after the therapy. The dosimetric measurements were performed in 10 patients. The exposure dose rate during the application of the therapy ranged from 2000 to 10000 pC/kg.s, during the visit from 528 to 15 pC/kg.s and during the examinations of patients from 5500 to 200 pC/kg.s. The average safety distance from patients for population was about 8.5 m on the day O (the very day of the therapy) and 2.0 m on the day 4, while for the medical staff it amounted to 5.0 m on the day 0 and 0.5 m on the day 4. The early complications perceived were as follows: radiation thyroiditis in 5/10 patients, stomach problems in 1/10 patients and transitorial leucopeny, forty days after the therapy, in 2/10 patients.

Adult↗
PubMed1990

[Inhalation scintigraphy in the diagnosis of pulmonary thromboembolism].

The purpose of this report is to realize the role of inhalation scintigraphy in the diagnostics of the pulmonary thromboembolic disease, as an addition to perfusion lung scintigraphy in the assessment of the nature of perfusion disturbances discovered by the perfusion scintigram. Perfusion lung scintigraphy, in itself, is a very sensitive indicator of a recent pulmonary thromboembolism but it is not sufficiently specific. The combining of perfusion and inhalation lung scintigraphy increases the specific quality of scintigraphic examinations in the diagnostics of lung thromboembolism.

Administration, Inhalation↗
PubMed1989

[Inhalation scintigraphy of the lungs and its clinical aspects].

The aim of the work was to examine the new Taplin's system for the production and inhalation of radioactive aerosol in routine diagnostic application. For that purpose a new commercially produced system of the firm CADEMA was used with a small modification which made possible its repeated application. The advantage of this system is a high level of aerosol particles of optimal size from 0.7-0.8 micron and inhalation is carried out only on the basis of air circulation caused by natural breathing. Total of 125 inhalation scintigrams was made. The results show that one can get aerosol of a high quality the distribution of which does not depend significantly on the sort of material marked with 99mTc. The distribution itself is even and scintigrams of high quality can be obtained. Inhalation scintigram of high quality combined with a perfusion scintigram enables reliable estimation of regional relationship between ventilation and perfusion of the lungs which is of special interest in the diagnostic of lung thromboembolism.

Humans↗
PubMed1979

Comparative chemical, biological and clinical studies of 99mtc-glucoheptonate and 99mtc-dimercaptosuccinate as used in renal scintigraphy.

The renal radiopharmaceutical preparations 99mTc-DMS and 99mTc-GH were examined chemically, biologically and clinically. Both preparations are of high radiochemical purity. The biodistribution of both preparations was examined in experimental animals at different time intervals, from 15 min to 4 hr; the precentage of incorporation of 99mTc-DMS into kindeys is much higher (29.4% to 52.0%) than that of 99mTc-GH (12.80% to 22.20%). Both preparations accumulate to a greater extent in the renal cortex than in the medulla. The most suitable time for renal scintigraphy for 99mTc-DMS is 90--150 min while for 99mTc-GH it is 60--90 min. It is concluded that 99mTc-DMS is more suitable for static scintigrams on the scanner and 99mTc-GH for dynamic studies with the gamma camera.

Animals↗
PubMedDate not supplied

[The beginnings and development of diagnostic imaging in nuclear medicine].

INTRODUCTION: The phenomenon of radioactivity was discovered in 1896 by Antoin Henri Becquerel, but its application in visual diagnostics started about fifty years later. RECTILINEAR SCANNER: It was constructed by B. Cassen and ass. in 1949, when first scintiscans were obtained. Technical improvements have been made 1950-1956 (B. Cassen and ass., R. Newall and ass., P. Bell, D. Kuhl). Soon after appearance of the first Cassen's scanner, commercial production began. GAMMA CAMERA: It was invented and constructed by H. Anger in 1957, improvements being made from 1958 to 1963. Gamma cameras are being commercially produced and sold since 1962; about ten years later they become widely used, and soon they pushed out the scanner from visual diagnostics. COMPUTER: Its use in scintigraphic diagnostics started in 1964 (H. Shepers, D. Wincler, D. Brown). From 1965 to 1974 various centers developed their own computer programs; after 1974 computers with incorporated nuclear medicine software packages became commercially available. TOMOSCINTIGRAPHY (SPET) AND POSITRON TOMOGRAPHY (PET): Numerous attempts to obtain tomographic images of organs using scanners and gamma cameras were made between 1963 and 1973 (D. Kuhl and R. Edwards, H. Anger, N. Charkes and R. Somburanasin et al.). The concept of contemporary single photon emission tomography (SPET) device was developed between 1974 and 1977 (J. Keyes and ass. and R. Jaszczak and ass.), while commercial production started in 1982. First cyclotrons for production of positron emitters, a prerequisite for positron emission tomography (PET) diagnostics, emerged in hospitals in 1955, and in last ten years they are being commercially made for these purposes. H. Anger (1959), M. Phelps, E. Hoffman and M. Ter-Pogossian (1975) set the grounds of PET; commercial production of PET systems started thereafter. CONCLUSION: Visual diagnostics in nuclear medicine reached its zenith in clinical practice during 1970-1980. It is partly pushed into the background by new imaging techniques (US, CT, MRI), but it only initiated further improvements (SPET, PET).

History, 19th Century↗
PubMedDate not supplied

[131-I-lipiodol in therapy of liver carcinoma--methods and case report].

INTRODUCTION: Primary malignant liver tumors are successfully treated only by means of surgery, but no more than 10% of patients are candidates for surgical intervention. The rest receive only palliative treatment which is, as a rule, unsuccessful. 131I-Lipiodol therapy (commercial label LIPIOCISTM) applied to the hepatic artery through a catheter has been used since 1984, primarily for treatment of hepatocellular carcinoma (HCC). The aim of this paper is to review the methodology of 131J-Lipiodol treatment of primary liver carcinomas. This treatment was applied for the first time in Yugoslavia. CASE REPORT: A female patient, 46 years of age had an inoperable primary liver carcinoma. Since progression of the disease couldn't be controlled by chemotherapy, treatment with 131I-Lipiodol was indicated. After blocking the thyroid with Lugol, Sol. 2.22 GBq of 131I-Lipiodol was injected into hepatic artery via catheter, and the patient was isolated in a designated facility until discharged. Around 5 months later, second therapeutic dose of 1.11 GBq was administered. Early post-therapy complications were severe, but transient. After 131I-Lipiodol therapy, the tumor growth was stopped, but the patient's general condition slowly deteriorated. The patient died 7 months after receiving the first therapeutic dose. CONCLUSION: In the reported patient, 131I-Lipiodol therapy stopped the tumor growth within the liver and significantly prolonged survival compared to the expected, but no improvement in quality of life was achieved. This treatment methodology is very complex. Medical staff providing care for these patients is exposed to substantial irradiation.

Adenocarcinoma↗
PubMedDate not supplied

[Goals and scientific achievements of the Institute of Oncology].

The Institute of oncology represents an oncological center which renders the measures of prevention, early detection and diagnostic of tumours and multidisciplinary strategy for antitumour treatment, including rehabilitation of patients suffering from tumours. To fulfil the above mentioned aims the Institute is organized in ten completely operative units and several functional centres and committees. The paper presents only few aspects of diagnostic and treatment of tumour, and the implementation of the programmes and targets of individual organizational units within the Institute. This orientation is particularly actual now when epidemiological studies show an increase of disease and mortality incidence in the region of Vojvodina.

Cancer Care Facilities↗