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Biomedical subjects

L Stenhammar

Publications and source records attributed to L Stenhammar.

80 records · Page 5Linked to original sources
PubMed1982

A family study of coeliac disease.

Small intestinal biopsy was performed in all 100 first-degree relatives of 32 index patients with childhood coeliac disease (CD) diagnosed according to the European Society for Paediatric Gastroenterology and Nutrition. CD was found in 2 relatives (2.0%), which means that first-degree relatives of coeliac children would run a ten-fold increased risk of CD compared with the general population of Sweden. Five relatives had a moderately abnormal mucosa. On rebiopsy they had a normal mucosa and are therefore not classified as having CD according to current diagnostic criteria. For practical purposes it would be impossible to perform a biopsy in all first-degree relatives of coeliac patients. However, relatives with a past history of symptoms suggestive of malabsorption and relatives with present signs of malabsorption should be candidates for biopsy.

Adolescent↗
PubMed1981

The incidence of coeliac disease in children in south-east Sweden.

Among children born between 1969 and 1977 in two areas of south-east Sweden an initial flat small intestinal mucosa was found in 84 cases, 64 of whom were considered to have coeliac disease (CD) diagnosed mostly according to the criteria formulated by the European Society for Paediatric Gastroenterology and Nutrition. The incidence of CD was 1/859, which is in agreement with that of a recent report from south Sweden. This suggests that the incidence of CD is the same in the whole of Sweden. In the present study all patients with an initial flat mucosa improved clinically and histologically after 1 year or more on a gluten-free diet. When challenged with gluten, 19% did not relapse within 2 years, thus fulfilling the criteria for so-called transient gluten intolerance. These patients had a lower mean age of symptom debut and for first biopsy, compared with the patients with CD.

Celiac Disease↗
PubMed1981

Transient gastro-intestinal disorders during infancy and early childhood. A follow-up study with special reference to coeliac disease.

In a reappraisal study of coeliac disease (CD) 38 children and adolescents were studied: 20 (group A) had a previous diagnosis of CD from early childhood but had been lost to follow-up, 18 (group B) had in infancy or early childhood been hospitalized for more than 1 month for different gastro-intestinal symptoms without receiving a diagnosis of CD. In the present study the patients had a clinical examination and Hb, serum IgA and folate were analysed. These investigations did not prove helpful in selecting coeliac cases. Intestinal biopsy revealed CD in 8 patients in group A and in 6 patients in group B. Thus the frequency of CD was almost the same in the two groups. All 14 patients with CD had very few complaints, when a careful medical history was taken before biopsy. The present study shows the importance of performing intestinal biopsy on liberal indications on patients with an infancy or early childhood history of malabsorption-related symptoms. Among these patients many coeliacs are likely to be found.

Adolescent↗
PubMedDate not supplied

Treatment with antioxidants at onset of type 1 diabetes in children: a randomized, double-blind placebo-controlled study.

BACKGROUND: In recent years different types of immune interventions have been tried at the onset of type 1 diabetes. Although some have shown effects, none have proven to be sufficiently effective to justify the inherent risks and side effects. Antioxidants have no or minimal side effects. If they can protect the beta cells against free oxygen radicals during the inflammatory process this would be a safe and cheap intervention. To evaluate this hypothesis a combination of various antioxidative agents was employed in a double-blind randomized study. METHODS: The study group comprised 46 children aged 1-17 years at diagnosis. They were followed for 3 years: 2 years whilst taking the tablets and 1 year of follow-up. Twenty-four children were randomly allocated to active treatment with high doses of antioxidants and 22 children to placebo tablets. The tablets were the same size and tasted identical. RESULTS: Twenty patients had for more than 1 month an insulin dose <0.5 U/kg in parallel with a normal HbA(1c) value and stable blood glucose values, but with no difference observed between those with and without active treatment. Nor was any significant difference observed regarding C-peptide values, fasting as well as stimulated. Whilst the antioxidants demonstrated no positive effect, they also had no negative side effects. CONCLUSION: At diagnosis of type 1 diabetes in children, high doses of antioxidative agents have no effect either on the preservation of beta cell function or on metabolic balance.

Adolescent↗
PubMedDate not supplied

Aneurysmal bone cyst of the femur in a child with celiac disease.

A case of aneurysmal bone cyst of the femur in a 2-year-old boy with celiac disease is described. The bone cyst presented with a pathological fracture while the boy was undergoing gluten challenge. The definite diagnosis of celiac disease according to the criteria formulated by the European Society for Paediatric Gastroenterology and Nutrition was established. A hypothetical association between the two disorders is discussed.

Bone Cysts↗
PubMedDate not supplied

The incidence of childhood celiac disease in Sweden.

Within a defined population in southeast Sweden, celiac disease was diagnosed in 167 children born between 1970 and 1982. The diagnosis was based on the criteria of the European Society for Paediatric Gastroenterology and Nutrition. Another six children had an initial flat small intestinal mucosa but do not yet fulfill the criteria for the diagnosis of celiac disease. The incidence of celiac disease was 1.27/1,000 live births for the years 1970-1976 and 1.43/1,000 for 1977-1982. In contrast to our findings, a decline in the disorder during the late 1970s was reported from other countries. We discuss the observation that the incidences of celiac disease in children are moving discrepantly in different populations.

Adolescent↗