Defining the chromosomal basis of mental handicap.
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Chromosome Aberrations↗
Biomedical subjects
L Stranc
Publications and source records attributed to L Stranc.
Complications, comorbidities, and mortality: improving classification and prediction.
OBJECTIVE: First, to compare the distribution of complications and comorbidities associated with 17 common surgical procedures. We then describe the effect of augmenting an ICD-9-CM version of the Charlson comorbidity index, given the possible confounding of comorbidities and complications, for three common inpatient surgical procedures: coronary artery bypass surgery, pacemaker surgery, and hip fracture repair. DATA SOURCES AND STUDY SETTING: Individuals having one of the above procedures between April 1, 1990 and March 31, 1994, identified from Manitoba Health hospital discharge data, and their extracted records. STUDY DESIGN: Design was cross-sectional and longitudinal using Manitoba data on hospital utilization and mortality. DATA COLLECTION/EXTRACTION: Manitoba hospital discharge abstracts permit identifying whether or not the diagnosis represents an in-hospital complication of care. Two data sets were created for each procedure, one including complication diagnoses and another with complications removed. PRINCIPAL FINDINGS: The degree to which complications contaminated estimation of comorbidity depended both on the procedures studied and on the covariates selected. The unique structure of the algorithm for the Charlson comorbidity index led to complication diagnoses having only a minor effect on the comorbidity score generated. Unless a data set affords the opportunity to remove complication diagnoses, the improvement in comorbidity detection afforded by augmenting the Charlson index, combined with the potential for overestimation of comorbidity, seem sufficiently modest to contraindicate such augmentation.
Algorithms↗
Analysis for linkage between F13A and three chromosome 6 marker loci: evidence for 6pter:F13A:HLA:GLO1:cen gene order.
The results of the present study provide independent support for F13A:HLA linkage and refine the F13A:HLA and F13A:GLO1 linkage relationships. Analysis of the corresponding recombination fractions for the total paternal F13A:HLA and F13A:GLO1 peak lod scores (z) indicates a locus order of 6pter:F13A:HLA:GLO1:cen. Lod scores between F13A and PLG, a locus recently assigned to chromosome 6, exclude close linkage between these loci.
Child↗