Biomedical subjects
Publications and source records attributed to L Sutton.
Azlocillin, carbenicillin, cefsulodin, mezlocillin, nocardicin A, piperacillin, pirbenicillin, sulbenicillin, and ticarcillin, but not HR756, showed reduced activity against Pseudomonas aeruginosa strains producing seven types of beta-lactamase.
Directional characteristics of spinal injections delivered via a 22 gauge Whitacre needle were confirmed in twenty-one obstetric patients undergoing elective Caesarean section. Caudad injection was inadequate for elective Caesarean section, while cephalad or lateral injection provided good sensory levels for the duration of the surgery. It is speculated that along with the low incidence of postspinal headache and ease of administering the block with a more rigid 22 gauge needle, low dose caudally directed injections may provide a superior means of administering saddle block analgesia for obstetric patients.
Plasmid-containing strains of Pseudomonas aeruginosa were screened for resistance to disinfectants. Two plasmids, pMG1 and pMG2, were found to determine hexachlorophene resistance.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Swimming as a response of the sea anemone Actinostola new species can be elicited as a result of contact with the submarginal surface of another swimming sea anemone Stomphia coccinea. However, Stomphia does not swim as a result of contact with Actinostola. In all other known respects, swimming is caused in both species by the same stimuli, including certain starfishes, a nudibranch, and electrical stimuli. No agent that causes Actinostola to swim has been detected in extracts, rubbings, or dried matter from Stomphia.
CONTEXT: The transmission of drug-resistant human immunodeficiency virus (HIV) has been documented, but the prevalence of such transmission is unknown. OBJECTIVE: To assess the spectrum and frequency of antiretroviral susceptibility among subjects with primary HIV infection. DESIGN, SETTING, AND PATIENTS: Retrospective analysis of 141 subjects identified from clinical research centers in 5 major metropolitan areas, enrolled from 1989 to 1998, with HIV seroconversion within the preceding 12 months and no more than 7 days' prior antiretroviral (ARV) therapy. MAIN OUTCOME MEASURES: Phenotypic and genotypic ARV susceptibility of HIV from plasma samples. RESULTS: The transmission of drug-resistant HIV as assessed by a greater than 10-fold reduction in ARV susceptibility to 1 or more drugs was observed in 3 (2%) of 141 subjects, including to a nonnucleoside reverse transcriptase inhibitor in 1 patient and to a nucleoside reverse transcriptase inhibitor and a protease inhibitor in 2 patients. Population-based sequence analysis of these 3 samples identified multidrug-resistance mutations in reverse transcriptase (M184V, T215Y, K219K/R) and protease (L101/V, K20R, M361, M46I, G48V, L63P, A71T, V771, V82T, 184V, L90M) in the 2 latter patient samples, along with numerous polymorphisms. A reduction in susceptibility of greater than 2.5- to 10-fold to 1 or more drugs was observed in viral isolates from 36 patients (26%). Sequence analysis of these 36 samples identified well-characterized drug resistance mutation in reverse transcriptase and protease in only 1 of these patients. CONCLUSIONS: Reductions in drug susceptibility of more than 10-fold were rare among this cohort of recently HIV-infected subjects and were distributed among each of the 3 major classes of ARV drugs tested. Reductions in susceptibility of more than 2.5- to 10-fold to certain ARV drugs of unknown clinical significance were highly prevalent among newly infected patients. Resistance testing may be warranted to monitor the frequency of drug resistance over time and to assess the potential for geographic variability.
Osteochondroma of the proximal fibula is relatively common, but reports of this lesion in conjunction with peroneal nerve palsy have been scarce. Six patients with peroneal nerve palsy and fibular exostosis are presented with the results of electrical studies, radiographic evaluation, physical examination, and operative treatment. A wide variation in presentation and outcome was observed. Preoperative and postoperative electromyography and nerve-conduction studies are useful in evaluation. A heightened awareness of this entity is required to avoid permanent damage in an otherwise treatable condition.
Several types of central nervous system tumors primarily consisting of a combination of astrocytes and fibrocollagen and occurring most commonly in infancy have been separately introduced as new diagnostic entities. The names applied to these tumors have included 'gliofibroma', 'desmoplastic cerebral astrocytoma', and 'desmoplastic infantile ganglioglioma', a group containing ganglion cells as well as the astrocytes and mesenchymal tissue. We studied a gliofibroma arising in the fourth ventricle of a 6-month-old infant and three examples of desmoplastic cerebral astrocytoma in infants utilizing routine histological and immunocytochemical methods, and at the ultrastructural level in two tumors. In view that the desmoplastic cerebral astrocytomas contain poorly differentiated neuroepithelial cells and rarely, a ganglion cell, we suggest that gliofibroma and desmoplastic astrocytoma are basically the same entity and that the desmoplastic infantile ganglioglioma is a variant containing primitive or mature ganglion cells.
This is the second article in our series which looks in detail at one of the most pressing nursing problems of the age--coping with the behaviours of people with dementia in acute care units. The authors analyse the misunderstandings and misperceptions which conspire to build barriers to communication between nurses and people with dementia, and offer some practical advice on how to overcome them.
Mitogen-activated protein kinase and Phosphatidylinositol-3 kinase/Akt-mediated signaling pathways play a major role in controlling cell proliferation, differentiation and cell death. Phosphorylation and dephosphorylation of their specific Thr/Tyr residues is critical in determining their activity. We determined the expression pattern and activity of MAP kinases and Akt in Primitive Neuroectodermal Tumors (PNETs). The kinase activity of extracellular signal-regulated kinase (ERK) was higher in both primary tumors and cell lines, as evident from the increased phosphorylation of ERK1 and ERK2. We did not observe the activation of C-jun N-terminal kinase (JNK) or p38 MAPK The expression of Raf-1, a kinase acting upstream of ERK, was significantly increased in primary tumors compared to normal brain. The PI-3 kinase-activated phosphorylation of Akt was also higher in primary tumors. These results suggest that activation of the Raf-1/ERK module of the MAP kinase pathway play an important role in PNETs.
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