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L Szabó

Publications and source records attributed to L Szabó.

At least 19 recordsLinked to original sources
PubMed1992

[Advantages and limitations of single-channel urodynamics in childhood].

The simultaneous recording of urodynamic parameters and x-ray imaging of the lower urinary tract is the ideal technique for a complex investigation of the lower urinary tract morphology and function. The urodynamic and micturating cystourethrography findings were reviewed in 57 children. The causes of the examinations were recurrent urinary tract infection, voiding dysfunction and urinary tract dilatation by ultrasound. 53/57 patients had a clear cystomanometry results. 4 did not cooperate. 15/53 had unstable bladder. 34/57 had vesico-ureteric reflux. Unilateral reflux was more frequently noted in children with an unstable bladder. In cases of a stable bladder, bilateral reflux occurred more frequently. The ureteric reflux in children with unstable bladder should resolve with therapy to decrease bladder activity. Urodynamics is complementary rather than competitive with radiologic investigations. It is necessary to make micturating cystourethrography with cystomanometry.

Age Factors↗
PubMed1992

Synthesis of allyl 6-O-(3-deoxy-alpha- and -beta-D-manno-oct-2- ulopyranosylonic acid)-(1----6)-2-deoxy-2-[(3R)-3-hydroxytetradecanamido]- beta-D-glucopyranoside 4-phosphate and of the copolymer of the alpha anomer with acrylamide.

The title disaccharides were synthesized by mercuric cyanide-catalyzed condensation of methyl (4,5,7,8-tetra-O-acetyl-3-deoxy-alpha-D-manno-oct-2-ulopyranosyl bromide)onate and allyl 2-[(3R)-3-acetoxy-tetradecanamido]-3-O-benzyl-2-deoxy-beta-D- glucopyranoside, followed by phosphorylation of the alcoholic function of the amino sugar. The phosphorylated anomers were separated by chromatography and deprotected by conventional methods. Polymeric material was obtained by copolymerisation, catalyzed by peroxosulphate and N,N,N',N'-tetramethylethylenediamine, of the alpha anomer with acrylamide; it contained ca. one disaccharide unit for 18 acrylamide residues.

Acrylamide↗
PubMed1992

[Adult-age Kawasaki disease].

The clinical history of a 65-years-old man is described by authors with typical symptoms of the Kawasaki disease. The clinical picture of this syndrome is characterized by high fever, characteristic changes of mucous membrane and skin and enlargement of cervical lymph nodes. The disease is most frequent in Japan and very rare after the age of eighteen. The specific features of the case is emphasized in the adulthood and attention is drawn to the fact that their case is the oldest one in the literature.

Age Factors↗
PubMed1992

[Urinary incontinence caused by sacral agenesis].

A rare cause of urine incontinence is sacral agenesis based on genetic or teratogenic disturbances. Abnormalities of the gluteal region can help in diagnosis. The sacral agenesis may be demonstrated by using anteroposterior X-ray examination. The early diagnosis is very important for the therapy and for the prevention of late complications.

Female↗
PubMed1992

Haptoglobin polymorphism in Hungary.

The haptoglobin phenotype was determined in 2609 blood samples collected from every Hungarian county. The results of the nation-wide survey are in agreement with those of a series of previous studies in which only Budapest inhabitants were investigated. However, a statistically significant difference was found in the haptoglobin phenotype frequency and distribution of people living west and east of the Danube. A lower HP*1 frequency was observed in the inhabitants of the eastern part of Hungary when compared to those living in the western part.

Female↗
PubMed1992

Endogenous scavenger levels (vitamin E and A) of patients with chronic alcoholic liver disease under different environmental conditions.

Serum level of endogenous scavengers (E and A vitamin) was studied in groups of patients with various chronic alcoholic liver diseases and in a healthy control group on polluted and non-polluted areas. Vitamin levels in patients with chronic liver disease are diminished in comparison to the healthy in general, but mainly in the cirrhotic group. Diminution of vitamin E levels was observed in earlier phase of liver disease than that of vitamin A levels. Patients and healthy control on polluted area showed more expressed diminution of vitamin levels than the same groups on non-polluted area. Free radical parameter (RBC diene conjugate content) and characteristic alcoholic parameters (serum GOT, gamma-GT, cholesterol level and liver GOT, gamma-GT content in biopsy specimen) were used to explain the differences between the same investigated groups on polluted and non-polluted areas. As conclusion can be supposed that industrial pollution of environment has a worsening effect in diseases with free radical mechanism.

Cholesterol↗
PubMed1992

[Experience with the surgical management of childhood fractures and epiphyseal injuries].

Authors analyse 1792 fractures in children, treated during 10 years in their Department and distributed in age groups. They take the part of conservative treatment of the majority, about two third, of fractures in childhood. They consider as operative indication certain forms of epiphyseal injuries, the dislocated intraarticular fractures, the unstable fractures, certain cases of polytrauma and the open fractures.

Adolescent↗
PubMed1991

Analysis of unmodified endotoxin preparations by 252Cf plasma desorption mass spectrometry. Determination of molecular masses of the constituent native lipopolysaccharides.

Nine unmodified endotoxin preparations constituted of Re-, Rd-, and Rc-type lipopolysaccharides (2 to 5 glycoses), representing four species of enterobacteria were analyzed by 252Cf plasma desorption mass spectrometry. The constituent lipopolysaccharides were characterized by the ion pair: (M-H)- and its corresponding lipid fragment ion. The lipid fragment ion is produced by cleavage of the glycosidic bond of the 3-deoxy-D-manno-oct-2-ulosonic acid unit that substitutes O-6' of the glucosamin beta 1'-6glucosamine ("lipid A backbone") disaccharide of the lipid A moiety. These lipid fragment ions were identical to the (M-H)- ions seen in the spectra of homologous isolated lipid A preparations that were obtained by hydrolysis (pH 4.5, 100 degrees C) promoted by sodium dodecyl sulfate. Since the molecular components present in the endotoxin preparations analyzed are known, the ion pair (M-H)(-)-lipid fragment ion defines the molecular compositions of each individual lipopolysaccharide. Heterogeneity of the R-type endotoxin preparations analyzed was due almost exclusively to differing lipid A moieties. In three Salmonella minnesota 595 Re endotoxin preparations 10 different lipopolysaccharides were identified, only two of which were common to all three preparations. Of the nine lipopolysaccharides identified in two S. minnesota R7 endotoxin preparations, only two were present in both.

Bacterial Toxins↗
PubMed1991

Synthesis of 2-deoxy-4-O-alpha- and -beta-D-mannopyranosyl-L-erythro-pentonic acids.

The title compounds, required for the identification of structural features of the Bordetella pertussis endotoxin, have been synthesised by condensation of benzyl 3-O-benzyl-2-deoxy-beta-L-erythro-pentopyranoside with 2,3,4,6-tetra-O-benzoyl-alpha-D-mannopyranosyl bromide and with 4,6-di-O-acetyl-2,3-O-carbonyl-alpha-D-mannopyranosyl bromide, respectively, thus affording the fully protected alpha- and beta-linked disaccharides 7 and 12. Hypoiodite oxidation of the reducing disaccharides 9 and 14, obtained by conventional deprotection of 7 and 12, yielded the title compounds.

Carbohydrate Sequence↗
PubMed1991

[Maternal Bartter syndrome and pregnancy].

The course of pregnancy, the parturition and postpartal period of a 19-year-old caucasian woman with Bartter syndrome was described. The pathogenesis, diagnosis, complications and the prenatal course of the autosomal recessive condition was also described by reviewing literary and own data. Analysis of amniotic fluid and ultrasound measurements showed unaffected fetus. The purpose of the paper was to summarize the suggested and recently applied prenatal care, maternal and fetal diagnostic and therapeutic measures in case of Bartter syndrome. Special emphasis was made on the prevention of fetal intrauterin growth retardation which frequently occurs in this condition.

Adult↗
PubMed1991

Vasodilator and angioprotective activity of 1-ethyl-1-hydroxyalkyl-octahydroindolo[2,3a]quinolizine derivates.

The blood flow enhancing activity of the homologue series of "trans" racemic 1-ethyl-1-hydroxyalkyl-1,2,3,4,6,7,12,12b-octahydroindolo[2, 3a]quinolizine (1) was studied in anesthetized dogs. It was found that the femoral vasodilator activity is the strongest for 1b, and decreases if the carbon chain is shortened (1a) or lengthened (1c). Also, a breakdown of vasodilation was observed with the racemic "cis" derivative (2). After resolution of 1b the optically active compound 3 retained the dilator capacity while 4 isomer lost it. Hence 3 (RHG-2981, vintoperol, CAS 106498-99-1) was selected for detailed pharmacological study. Dose-response studies performed in anesthetized dogs showed that vintoperol 0.03 mg/kg (i.v.) was more potent as peripheral vasodilator than buflomedil or pentoxifylline at doses ranging from 1 to 15 mg/kg. Similar results were observed during a 4-week cross-over test of maximal running distance of femoral ligated mice. The running performance, as measured by the rotating drum, showed a linear increase in the untreated control group (UCG) as a consequence of every day testing (= intensive endurance training). After bilateral femoral occlusion the maximal running distance of the mice fell off, and despite daily training it stagnated. If 0.3 or 1 mg/kg/d vintoperol or 10 mg/kg/d pentoxifylline was administered orally 4 days after the bilateral femoral occlusion, the maximal running distance increased. In the case of 1.0 mg/kg of vintoperol applied daily, the rate of enhancement approached, or even overtook, that of the UCG. 0.3 mg/kg/d of vintoperol showed less activity, however, this result is still about twice better than the effect of 10 mg/kg/d pentoxifylline.

Animals↗
PubMed1991

[Tensile strength of new and modified flexor tendon sutures].

Authors tested modified and new sutures and different sewing materials on the deep flexor tendons of the hand in cadavera. Tensile and pull strength examinations were performed. The results were compared with the Kirchmayr-Kessler suture. Suture types suitable for immediate postoperative active motion exercises are suggested.

Cadaver↗
PubMed1990

Variations in the carbohydrate regions of Bordetella pertussis lipopolysaccharides: electrophoretic, serological, and structural features.

Structural and immunological differences between the two components that are usually present in unequal quantities in Bordetella pertussis endotoxin preparations and are visualized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis have been studied by using strains 1414, A100, and 134, all in phase I. According to analyses by both sodium dodecyl sulfate-polyacrylamide gel electrophoresis and thin-layer chromatography, the minor (8%) component of the endotoxin of strain 1414 (endotoxin 1414) appeared to be the predominating component of endotoxins A100 and 134. The masses of the carbohydrate chains isolated from endotoxin A100 and from the major component of endotoxin 1414 were 1,649 and 2,311 atomic mass units, respectively, as determined by 252Cf plasma desorption mass spectrometry. Comparison of the 1H nuclear magnetic resonance spectra of these chains established that four N-acetyl groups, an N-methyl group, and a 6-deoxy function, which characterize the nonreducing, distal trisaccharide of the glycose chain of strain 1414, were absent from that of strain A100. The antigenicity of endotoxin 1414, as measured by enzyme-linked immunosorbent assay, was higher than that of endotoxin A100, but fell below it when the glycose chain of endotoxin 1414 was deprived of seven sugars by treatment with nitrous acid. This observation suggests that at least three (distal, proximal, and intermediate) regions of the glycose chain of endotoxin 1414 carry antigenic determinants. One of these, located in the distal trisaccharide, is absent from both endotoxins A100 and 134.

Bordetella pertussis↗
PubMed1989

[Ultrasonic detection of a tumor of the posterior cranial fossa in an infant].

The sonographic diagnosis and surgical treatment of the ependymoblastoma of a 9,5-month old infant is reported. The tumor originated from the posterior scale and caused obstruction in the aquaeductus cerebri and hydrocephalus. The modern radiological diagnosis of tumors in the posterior scale is reviewed.

Brain Neoplasms↗
PubMed1989

Influence of metal ions on the acquisition and quality of 252Cf plasma-desorption mass spectra.

The presence of a few mol per cent of Ca2+ ions considerably modified the 252Cf plasma-desorption mass spectrum of a phosphorylated glycolipid. In the negative-ion mode, increasing amounts of Ca2+ caused gradual disappearance of the spectrum; it was quenched at the molar ratio 3 Ca2+/4 glycolipid. Clusters as big as 5500 were observed at certain ratios of Ca2+/glycolipid. Similar, but less pronounced effects were seen in the positive-ion mode.

Calcium↗
PubMed1988

[BCG osteitis].

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BCG Vaccine↗