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Biomedical subjects

L Szelepin

Publications and source records attributed to L Szelepin.

4 recordsLinked to original sources
PubMed2000

[Use of YAG-Selecta laser and argon laser in the treatment of open angle glaucoma].

INTRODUCTION: The falling success rate of ALT (Argon Laser Trabeculoplasty) has raised the interest in some new laser techniques, such as q-switched Nd:YAG laser trabeculoplasty (Coherent Selecta 7000). The "selective" laser trabeculoplasty destroys melanosomes of pigmented trabecular meshwork cells, sparing adjacent non-pigmented cells and tissues. AIM: Our goal was to establish the IOP lowering effect of selective laser trabeculoplasty (SLT--Selecta Laser Trabeculoplasty) in comparison with ALT. MATERIAL AND METHODS: We have examined 27 patients (10 men, 17 women) aged 35-82, with open angle glaucoma and visual field deterioration despite maximal tolerated topical therapy (21 patients--POAG, 3--NPG, 1--pigmentary glaucoma, 1--pseudoexfoliative glaucoma, 1--juvenile glaucoma). One eye of each patient was randomly chosen for SLT, the other eye underwent ALT. In each method 50 burns were applied in 180 degrees angle with power settings of 600-1000 mW for ALT and energy settings of 0.5-1.4 mJ for SLT. The IOP was measured 1 hour before laser treatment and 1, 2, 24 hours and 3 months after treatment. RESULTS: The mean initial IOP in eyes selected for SLT was significantly higher (21.26 +/- 4.82 mm Hg) than in eyes selected for ALT (20.26 +/- 4.01 mm Hg), t-test: p = 0.037. However, there was no statistically significant difference in the IOP lowering effect between eyes treated with SLT and eyes treated with ALT. The mean IOP drop from the pre-treatment values was -2.85 +/- 4.62 mm Hg after SLT and -2.63 +/- 3.60 mm Hg after ALT (t-test, p = 0.84). All values: 2, 24-hours and 3 months after treatment were significantly lower than pre-treatment values in both groups (t-test, p < 0.03). Only in the 1st hour after SLT the IOP drop was not significant. There was a significant correlation between the amount of pigment on the trabecular meshwork and the IOP fall (U Mann-Whitney test). In SLT group 6 patients (21%) developed mild iritis during 1st day after laser treatment, which disappeared after fluorometholon drop therapy. CONCLUSION: Both methods--SLT and ALT--have equivalent IOP lowering effect in short time observation (3 months). Due to entirely novel mode of Selecta laser action, long term results may show significant differences.

Adult↗
PubMed1997

[Correlations between morphologic measurements of the optic disc using planimetric tests and changes in the visual field in patients with glaucoma].

PURPOSE: To evaluate the relationships between planimetrical measurements of the optic disc and visual field indices in primary open-angle glaucoma patients and glaucoma suspects. MATERIALS AND METHODS: Materials consisted of 64 patients (128 eyes) divided into two groups: glaucoma suspects without any treatment (30 patients, 60 eyes) and early open-angle glaucoma patients already medically treated (34 patients, 68 eyes). All the patients underwent the full, computerized, planimetrical analysis of the optic disc. A special attention was paid to the neuroretinal rim measurements. Visual field examination was performed with automated perimeter Octopus 101 using test dG2. Results were analysed with the use of "Interzeag Peridata" software. RESULTS: We found the statistically significant correlations between neuroretinal rim area and visual field parameters in the glaucoma group. The highest relationship concerned mean defect and compound index of the field. There were no such correlations in glaucoma suspects. Cup/disc ratio correlated more weakly with visual field than neuroretinal rim area. We also analysed mean and extreme values of the neuroretinal rim area in groups of different depth and configuration of visual field defects. CONCLUSIONS: Neuroretinal rim area is a more valuable planimetrical parameter in optic disc analysis than cup/disc ratio. It is also an important factor affecting the visual field, but probably not the only one. There is a significant correlation between visual field quantitative parameters and neuroretinal rim area in primary open-angle glaucoma patients, but in glaucoma suspects that is not true. Digital planimetry proved to be a valuable tool for optic disc biomorphometry and it seems to be an objective method for detecting development of structural changes in glaucoma.

Adolescent↗
PubMed1997

[Comparative analysis of changes in the visual field in primary open-angle glaucoma and glaucoma with normal tension].

PURPOSE: To compare the pattern and the depth of visual field defects of POAG and NTG patients. MATERIALS AND METHODS: The visual fields in two groups of POAG and NTG patients, each counting 25 eyes, were analysed statistically. All eyes were tested at least twice, employing full threshold G2 test of Octopus 101 (Interzeag) automatic perimeter. The tests with the highest reliability level were included. The analysis was performed using Peridata (Interzeag) statistical package. Mean values of mean defect (MD), corrected loss variance (CLV) and compound index (CI) for each group were acquired. Furthermore, main values of MD for upper and lower hemifield, quadrants and 10 degrees concentric rings, were obtained. The differences between the two groups were tested for the statistical significance. RESULTS: Values of all three above parameters (MD, CLV i CI) were significantly lower in the group of eyes with POAG as compared with those with NTG. In both groups mean MD was higher in the upper hemifield, but the upper/lower hemifield ratio was significantly higher in the POAG group (1.50) as compared with NTG group (1.05). In POAG group the highest mean MD was found in the upper-temporal quadrant whereas in NTG group the lower-nasal quadrant was the most affected. In both groups the highest values of mean MD were found in the outer ring between 20 degrees and 30 degrees of visual field but the difference between the centre and periphery was considerably lower in NTG group. CONCLUSIONS: The results support the opinion that there exist differences between the patterns of visual field changes in POAG and NTG. The loss tends to be more diffuse in POAG, showing deeper defects in the periphery and stronger tendency to affect the upper hemifield.

Adult↗