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Biomedical subjects

L Szymanski

Publications and source records attributed to L Szymanski.

14 recordsLinked to original sources
PubMed2002

Metabolic signals, hormones and neuropeptides involved in control of energy balance and reproductive success in hamsters.

In the 'postgenome era', most research on the neuroendocrine control of energy homeostasis has focused on hormonal and neuropeptide control of food intake (i.e. the amount of food eaten) in rats and mice. The amount of food consumed is influenced by both the motivation to procure food and the consummatory act of ingestion. In some species, the rate of food intake remains relatively constant, while survival is maintained via changes in food procurement, external storage and internal expenditure. For example, in hamsters, metabolic signals, peripheral hormones and central neuropeptides influence hunger motivation, food hoarding and changes in energy expenditure without necessarily influencing the amount of food ingested. A similar suite of metabolic signals, hormones and neuropeptides is involved in optimizing reproductive success under fluctuating energetic conditions. Reproductive processes are inhibited or delayed when energy expenditure outstrips energy intake and mobilization from storage. Estrous cyclicity in Syrian hamsters is sensitive to the availability of oxidizable glucose, but the presence of central glucose alone is not sufficient for normal estrous cycles. Food deprivation-induced anestrus does not depend upon food deprivation-induced increases in concentrations of adrenal hormones such as glucocorticoids. If hormones such as insulin and leptin play a role, they might do so by modulating the availability of glucose detected at extra-hypothalamic sites, instead of or in addition to direct effects on the mechanisms that control gonadotropin releasing hormone secretion. Despite our ability to measure and manipulate gene transcription, understanding of fuel homeostasis requires examination of indirect effects of hormones and neuropeptides on peripheral metabolism, attention to the motivational as well as consummatory aspects of ingestion, and the study of behaviour in a natural or seminatural context.

Animals↗
PubMed1999

Changes in self-efficacy and decisional balance for exercise among obese women in a weight management program.

OBJECTIVE: To assess changes in eating and exercise self-efficacy and decisional balance for exercise in an obese population enrolled in a multi-disciplinary weight management program. RESEARCH METHOD AND PROCEDURES: Thirty-two obese women were assessed at entry and after 12 weeks of treatment. RESULTS: Participants showed 15% mean weight loss after 12 weeks of treatment. Mean minutes of self-reported exercise increased by 229%. Participants demonstrated significant improvements in self-efficacy for both eating and exercise and health parameters but not in decisional balance for exercise adoption. DISCUSSION: These results may have implications for the practitioner in that self-efficacy changes occur during successful weight loss, but decisional balance for exercise may not change until individuals enter maintenance. These results imply that practitioners may be advised to shift from confidence building to relapse prevention early on in treatment, and that focusing on strengthening the pros of exercise and reducing the cons of exercise may need to remain constant during treatment.

Adult↗
PubMed1999

Practice parameters for the assessment and treatment of children, adolescents, and adults with mental retardation and comorbid mental disorders. American Academy of Child and Adolescent Psychiatry Working Group on Quality Issues.

Mental retardation (MR) is a heterogeneous condition defined by significantly subaverage intellectual and adaptive functioning and onset before age 18 years. With an approach underscored by principles of normalization and the availability of appropriate education and habilitation, persons with MR generally live, are educated, and work in the community. Mental disorders occur more commonly in persons with MR than in the general population. However, the disorders themselves are essentially the same. Clinical presentations can be modified by poor language skills and by life circumstances, so a diagnosis might hinge more heavily on observable behavioral symptoms. The diagnostic assessment considers and synthesizes the biological, psychological, and psychosocial context of mental disorders. Comprehensive treatment integrating various approaches, including family counseling, pharmacological, educational, habilitative, and milieu interventions is the rule.

Adolescent↗
PubMed1999

Summary of the Practice Parameters for the Assessment and Treatment of Children, Adolescents, and Adults with Mental Retardation and Comorbid Mental Disorders. American Academy of Child and Adolescent Psychiatry.

This summary provides an overview of the assessment and treatment recommendations contained in the Practice Parameters for the Assessment and Treatment of Children, Adolescents, and Adults With Mental Retardation and Comorbid Mental Disorders. The parameters were written to aid clinicians in the assessment and treatment of children, adolescents, and adults with symptoms of mental retardation (MR) and comorbid mental disorders. MR is a heterogeneous condition defined by significantly subaverage intellectual and adaptive functioning and onset before age 18 years. With an approach underscored by principles of normalization and the availability of appropriate education and habilitation, persons with MR generally live, are educated, and work in the community. Mental disorders occur more commonly in persons with MR than in the general population. However, the disorders themselves are essentially the same. Clinical presentations can be modified by poor language skills and by life circumstances, so a diagnosis might hinge more heavily on observable behavioral symptoms. The diagnostic assessment considers and synthesizes the biological, psychological, and psychosocial context of mental disorders. Comprehensive treatment integrating various approaches, including family counseling, pharmacological, educational, habilitative, and milieu interventions is the rule.

Adolescent↗
PubMed1998

Longitudinal changes in college students' exercise participation.

A 4-page questionnaire was mailed to 708 randomly selected 1st-year university students to assess changes in the students' exercise behavior from the 1st year of college to the 2nd year. The questionnaire assessed student demographics and participation in vigorous and moderate exercise over the preceding 7 days. Three hundred thirty-two students responded. A year later, a similar questionnaire was mailed to the same 332 students; responses were obtained from 242 students. Although no changes in reported exercise participation were found in the group as a whole, subgroups of students who either increased or decreased exercise participation were identified. Implications for exercise intervention programs among college students are presented.

Adolescent↗
PubMed1997

Services for people with mental retardation and psychiatric disorders: US-UK comparative overview.

Mental health services for people with mental retardation have been receiving greater attention over recent years following a long period of inactivity. The main policy factors which influenced the developments of services were in the USA, the emphasis on deinstitutionalisation and normalisation, and in the UK the focus on social care. Progress in the assessment of psychiatric disorders and improved diagnostic techniques have stimulated the development of a wide range of mental health services for people with mental retardation, compatible with current ideology of community care on both sides of the Atlantic. Specialist multidisciplinary, community based and easily accessible mental health services should be available for people with mental retardation. Economic cost, quality of care, and training of professionals and direct care staff, remain some of the challenges faced by purchasers and providers of mental retardation and mental health services in both countries.

Humans↗
PubMed1997

Exercise in weight management.

Exercise is integral to successful weight loss and maintenance. When talking to patients about exercise, consider their readiness, and address the barriers that prevent exercise. Physicians can help those patients who already exercise by encouraging them to continue and helping them anticipate, and recover from, lapses. Providing resource material to patients on behavioral strategies for exercise adoption and weight management can supplement the physician's efforts. Overall, patients need to hear that any regular exercise, be it step-aerobics, walking, or taking the stairs, will benefit them.

Exercise↗
PubMed1987

Naltrexone in treatment of self injurious behavior: a clinical study.

It has been suggested that the parenteral opiate antagonist, naloxone, might ameliorate self-injurious behavior. However, clinical studies have had conflicting results. We have evaluated whether a potent oral opiate antagonist, naltrexone, is effective in the treatment of this condition. The study was conducted on two young, profoundly mentally retarded adults, who exhibited intractable self-injurious behavior. A double-blind, placebo-controlled, within-subject-withdrawal design was utilized. One subject was studied for 12 weeks and the other one for 18 weeks. No measurable effects on the self-injurious behavior were observed.

Adult↗
PubMed1976

[Variations in the loudness of a brief sound compared to another brief sound as a function of the duration of both sounds].

Loudness equalizations between two short 2500 Hz tones (15 to 120 ms, about 50 dB SPL) were made. One tone, either the first or the second one, was twice as long as the other. The intensity level differences between tones of the same loudness were calculated. Results show that the relations between duration and loudness of the tones differ for different subjects. Nevertheless the calculated differences diminished with subject experience. Subject evaluations in accordance with the intensity levels of tones, i.e. independently of the duration, were quite often obtained even for the pairs 15 ms-30 ms.

Acoustic Stimulation↗
PubMed1976

[Relationship between evaluation of the duration and loudness of short sounds].

The relation between loudness and duration judgments of short tones was investigated. Sounds (15 to 120 ms, 2500 Hz, about dB SPL), were exposed in pairs; one tone of the pair, the first or the second one, was twice as long as the other. Subjects had to compare the loudness of the tones, or the duration, or the loudness and the duration at the same time. Results show that the loudness judgments are independent of experiences with duration judgments and of immediate duration judgments, but duration judgments were less precise when loudness judged at the same time.

Auditory Perception↗
PubMedDate not supplied

A comparison of questionnaire and physiological data in predicting future chronic disease risk factor status in an employee population.

BACKGROUND: The ideal screening tool for worksite health screening programs has not yet been identified, and the effectiveness of screening programs in predicting future chronic disease risk factors status is not well understood. This study compared two commonly used screening tools, health-related questionnaires and measurement of physiological parameters, in terms of their ability to predict future chronic disease risk factor status in an employee population. METHODS: Data were collected over a 10-year period from Liberty Corporation employees (N = 723). Baseline evaluation included the administration of questionnaires and measurement of physiological data. Follow-up evaluation measured physiological data only. Regression analyses identified the statistically significant predictors of future risk factor status using 1) baseline questionnaire data; 2) baseline physiological data; and 3) both questionnaire and physiological data as predictor variables. RESULTS: Although both screening methods were able to predict future risk factor status, R 2 values were higher in models including baseline physiological measures than models including questionnaire data only. Adding questionnaire data to physiological data provided little or no additional predictive ability. DISCUSSION: These results suggest that physiological data, particularly baseline measures of a risk factor, are more predictive of future risk factor status than questionnaire data.

Adult↗