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L T Gutman

Publications and source records attributed to L T Gutman.

43 records · Page 3Linked to original sources
PubMed1967

The role of penicillin-induced bacterial variants in experimental pyelonephritis.

1. After injection into the renal medulla of rats Escherichia coli 06 variants reverted rapidly in vivo in the absence of penicillin. These variants had previously been shown to be stable in vitro. 2. Variants failed to survive following intramedullary injection when animals were receiving penicillin. 3. Late reversion of variants also failed to occur in animals treated with penicillin for only 1 or 2 days. 4. Variants survived and reverted more readily when injected in the renal medulla, compared with liver and spleen. Classical bacteria injected into the kidney, liver, and spleen were recovered in approximately equal numbers. 5. The histologic response to nonreverting variants, medium not containing variants, and killed variants was similar and was characterized by a fibrotic reaction with moderate round cell infiltration. 6. In contrast, the histologic response to reverting variants and to classical E. coli was characterized by an intense, acute, polymorphonuclear leukocytosis typical of acute pyelonephritis.

Animals↗
PubMedDate not supplied

Association of coexisting vaginal infections and multiple abusers in female children with genital warts.

All 11 girls less than 12 years of age presenting to the pediatric clinic between 1980 and 1986 with genital warts were evaluated by the Child Protection Team for possible sexual abuse. Nine of the 11 girls had condylomata acuminata, and two had verruca vulgaris. Ten of the 11 had historical and/or physical evidence other than the warts that confirmed sexual abuse. Six girls had coexisting vaginal infections such as bacterial vaginosis and infections due to various pathogens including Neisseria gonorrhoeae, Trichomonas vaginalis, Ureaplasma urealyticum, and Mycoplasma hominis. These six girls were known (three) or suspected (three) of being abused by multiple perpetrators. None of the five girls with a known or suspected single abuser had coexisting vaginal infections (P = less than 0.02, Fisher's exact test). We conclude that almost all genital warts in girls are sexually transmitted and that girls presenting with anogenital warts should be evaluated for other genito-vaginal infections and sexual abuse. Multiple vaginal infections in childhood, with organisms that are sexually transmitted or associated with sexual activity, may be a marker for abuse by multiple perpetrators.

Anus Neoplasms↗
PubMedDate not supplied

Counterimmunoelectrophoresis of synovial fluid in the diagnosis of septic arthritis.

The evaluation by counterimmunoelectrophoresis (CIE) of joint fluid for bacterial antigen from 16 children with suspected septic arthritis is reported. Joint fluid from six children contained capsular antigen of Haemophilus influenzae type b (four) or Streptococcus pneumoniae (two). One child was infected with S. pneumoniae but was positive by CIE for both H. influenzae type b and S. pneumoniae. Five of six children who were less than 2 years of age were infected with H. influenzae. Two children had negative cultures of joint fluids, and a presumptive etiology for their infection was proposed only by demonstration of bacterial antigen. CIE, which has been widely applied to cerebrospinal fluid, urine, and serum, is a helpful adjunct to the evaluation of joint fluid from children with suspected septic arthritis.

Antigens, Bacterial↗