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Biomedical subjects

L T Wang

Publications and source records attributed to L T Wang.

4 recordsLinked to original sources

[Immunohistochemical study on clear cell chondrosarcoma].

Clear cell chondrosarcoma, a subtype and separate entity from the conventional chondrosarcoma, is characterized by its special histologic features, site of predilection, slow growth and better prognosis. Three cases are presented with elucidation of clinicopathologic correlation and detection by ABC immunohistochemical method using several antibodies. The observation of positive reaction to S-100 protein, vimentin, anti-alpha-chymotrypsin and Lysozyme by the tumor cells of clear cell chondrosarcoma, similar to chondrosarcoma and chondroblastoma, proves that this tumor has its origin from the cartilaginous tissue. It was found for the first time that the clear cell chondrosarcoma was positive for wheat germ agglutinin and concanavalin A. The authors believe that clear cell chondrosarcoma may result from the anaplastic change of chondroblastoma cells into another subtype of that tumor. The osteoblastlike multinucleated giant cells, retaining the antigens of phagocytes, are not considered to be neoplastic.

Adult

[Hepatobiliary tuberculosis].

An analysis of 423 cases with hepatic and biliary tuberculosis was reported. The hepatic tuberculosis may be divided into miliary, nodular and abscess type, the biliary tuberculosis may be divided into cholecystic and biliary type.

Adult

Giant cell tumors of bone. An immunohistochemical study.

Immunohistochemical study of giant cell tumor of bone (GCT) was carried out utilizing a panel of monoclonal antibodies including those against lysozyme, alpha-antichymotrypsin (AACT), vimentin (Vim), M718, HLA-DR, S-100 protein, epithelial membrane antigen (EMA), leukocyte common antigen (LCA), KB90, factor VIII related antigen (F VIII) against stromal cells and giant cells in 20 cases of GCT, with one case of prolonged continuously cultured cells GCT (GT 15). The results showed that stromal cells could be divided into two subgroups. Mesenchymal stromal cells labelled only with vimentin and were regarded as being derived from undifferentiated mesenchymal cells of bone marrow, while macrophage-like stromal cells labelled with antigens and were found to be present in mononuclear phagocytes. We believe this to be the first report that some stromal cells reacted positively with S-100 protein. Multinucleated giant cells were AACT and M718 positive, indicating their close relationship to macrophage-like stromal cells. The prolonged cultured cells accepted labelling with vimentin only indicating that all macrophage-like stromal cells disappeared after several subcultures and the only cells that could continue to be subcultured were the mesenchymal stromal cells.

Bone Neoplasms