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Biomedical subjects

L Tóth

Publications and source records attributed to L Tóth.

At least 91 records · Page 5Linked to original sources
PubMed1983

Calcium-containing mitochondrial granules in neurohypophysial axon terminals disappear following vasopressin treatment of Brattleboro rats.

The presence of intramitochondrial calcium-containing electron-dense granules was demonstrated in axon terminals of chronically hyperactive neurosecretory neurons of untreated homozygous Brattleboro rats. Following vasopressin treatment for 30 days, which has been shown to attenuate this neuronal hyperactivity, calcium-containing deposits could not be detected in mitochondria. It is concluded that the presence of intramitochondrial calcium-containing dense deposits is connected with the functional state of neurosecretory neurons.

Animals↗
PubMed1983

Enzyme cytochemistry of the cerebral microvessel wall.

The cytochemical localisation of five hydrolytic enzymes has been studied in the brain capillaries of laboratory animals. Acid phosphatase is present in primary lysosomes of endothelial cells; alkaline phosphatase activity is seen mainly on the plasma membrane of the luminal side but also in the basal lamina. The latter is also active concerning 5'nucleotidase. Butyrylcholinesterase is an enzyme synthesized by most brain capillary endothelial cells, as can be seen by intensive staining of endoplasmic reticulum cisternae. In contrast acetylcholinesterase activity at the capillaries presumably is of neuronal origin. Local neurons appear to secrete this enzyme, which then reaches the endothelial basal lamina via the extracellular spaces. From these cytochemical observations it is concluded that pinocytotic traffic in brain endothelial cells is predominantly from the brain tissue side to the luminal side.

5'-Nucleotidase↗
PubMed1983

[Subcellular localization of calcium in the neurosecretory axon terminals of the neurohypophysis of the rat following stimulation by administration of hypertonic salt solution].

The calcium accumulating capacity of neurohypophysial axon terminals stimulated by the intravenous injection of hypertonic saline has been studied by using light and electron microscopic histochemical methods and X-ray microanalysis. In the stimulated neurosecretory terminals Ca++ containing granules appeared in the mitochondria. Smaller granules of similar morphological appearance occurred in the smooth endoplasmic reticulum as well. It is suggested that the mitochondria and the smooth endoplasmic reticulum are intimately involved in the regulation of the intraaxonal free calcium level during the process of vasopressin secretion.

Animals↗
PubMed1983

Primary inflammatory carcinoma of the breast.

Among 2775 cases of breast cancer examined over a 10-year period, primary inflammatory carcinoma was diagnosed in 35 patients. The symptomatology, the clinical and pathological features and problems of differential diagnosis of primary inflammatory carcinoma of the breast are discussed in detail. On the basis of data in the literature and their own experience, the authors do not recommend surgical treatment of the disease.

Breast Neoplasms↗
PubMed1982

Morphological evidence for the involvement of calcium in neurohypophysial hormone release.

An elevated intracellular Ca2+ concentration in the secretory nerve endings of the rat neurohypophysis was detected histochemically by means of light microscopy concomitant with the vasopressin secretion evoked by hypertonic saline. The electron microscopic and X-ray microanalytical results furnish morphological evidence for the function-dependent Ca2+ storage capacity of the mitochondria, and suggest their role in the regulation of the free Ca2+ level in the neurosecretory axon terminal.

Animals↗
PubMed1982

[Changes in the butyrylcholinesterase activity of fenestrated capillaries in the area postrema during postnatal development].

Ontogenetic changes in butyrylcholinesterase (BuChE) activity of fenestrated capillaries in the rat Area postrema lying outside of the blood-brain barrier were investigated by means of light and electron microscopic histochemical methods. Marked enzyme activity could be demonstrated in the capillary endothelial cells of the neonatal rat. The intensity of the light microscopically detectable BuChE activity in the capillaries decreased gradually during the postnatal ontogenesis, but the capacity of the enzyme synthesis of the endothelium remained unchanged in the adult rat, too. Our results do not indicate any direct correlation between BuChE positivity of capillaries and the existence of the blood-brain barrier.

Aging↗
PubMed1981

Evidence for the neuronal origin of brain capillary acetylcholinesterase activity.

Acute administration of monosodium-L-glutamate (MSG) to rats induces the degeneration of acetylcholinesterase (AChE)-positive neurons of the area postrema (AP). Chronic treatment with MSG results in the disappearance of AChE activity of area subpostrema (ASP) capillaries. It is concluded that processes of AChE-positive AP neurons terminate within the ASP and may contribute to the AChE activity of ASP capillaries.

Acetylcholinesterase↗