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Biomedical subjects

L TETREAULT

Publications and source records attributed to L TETREAULT.

At least 19 recordsLinked to original sources
PubMed1965

A PHARMACOLOGY TEACHING EXERCISE IN DRUG EVALUATION: A COMPARISON OF THE DIURETIC EFFICACY OF CLOREXOLONE, HYDROCHLOROTHIAZIDE AND A PLACEBO IN NORMAL SUBJECTS.

In 63 healthy medical students, grouped in 21 randomized blocks, the comparative effects of clorexolone, hydrochlorothiazide and placebo on the quantity of urine excreted and on weight loss were studied. Each subject ingested a single 50-mg. dose of one of the medications. An oral saltloading technique was employed. Measurements were recorded during the four hours following administration. This experiment, which was an integral part of a teaching program in pharmacology, permitted a practical demonstration to medical students of the four fundamental control measures in clinical pharmacology: the comparison with a standard medication and/or a placebo, the random distribution of treatments, the double-blind technique and the statistical analysis of data. In this study hydrochlorothiazide proved to have significantly greater diuretic activity than placebo and clorexolone; the latter medication did not demonstrate effects statistically superior to those of the placebo. A highly significant positive correlation was found to exist between the measurements of urine volume and weight loss.

Biomedical Research↗
PubMed1964

[COMPARATIVE EVALUATION OF THE SUBJECTIVE EFFECTS OF DEXTROAMPHETAMINE, METHYLPHENIDATE AND PLACEBO].

The subjective effects of dextroamphetamine, methylphenidate and placebo were evaluated in 16 medical students during the period just prior to their final oral examinations. The subjects served as their own controls. The order of administration of the three medications for each student was randomized, and a double-blind technique was used throughout. A questionnaire method was employed for the collection of results, which proved to be a useful and effective means. It demonstrated that dextroamphetamine, methylphenidate and placebo were statistically different from one another with regard to their effect on efficiency of studying, fatigue, duration of sleep and appetite. There were also significant differences in the number of side effects caused by the three medications. The stimulants, however, did not increase the number of study hours, nor was their use recommended by the students when preparing for important examinations.

Appetite↗
PubMed1964

COMPARATIVE ANALGESIC ACTIVITY OF LEVOMEPROMAZINE AND MORPHINE IN PATIENTS WITH CHRONIC PAIN.

Apart from its ability to potentiate the action of narcotics, levomepromazine, a phenothiazine derivative, was shown to possess its own analgesic activity comparable to that of morphine at a 3:2 dose relationship.In a double-blind crossover study of 18 patients suffering from chronic pain (cancer and arthritis), levomepromazine (15 mg.) was compared with morphine (10 mg.) and placebo. Three hours after intramuscular administration, levomepromazine proved to be significantly superior to placebo (p < .05) and indistinguishable from morphine. Evaluations of pain relief by estimations of changes in pain intensity were found to correlate well with evaluations based on recognition of pain relief exceeding 50%.The potent analgesic effect of levomepromazine was obtained at the price of excessive sedation. This, however, was considered an acceptable side effect in a patient suffering from chronic pain. These results provide encouragement in the quest for a non-addicting substitute for morphine.

Analgesics↗