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Biomedical subjects

L Tamsen

Publications and source records attributed to L Tamsen.

14 recordsLinked to original sources
PubMed1994

HLA antigen sharing in preeclampsia.

The association between human leukocyte antigens (HLA) and the development of preeclampsia (PE) was studied in 48 women with PE and their partners. In 20 of the families, the HLA antigens of the child were also determined. In 8 of 15 cases (53%) of primigravidae with PE, the child shared at least 2 paternal antigens with the mother, whereas this was the case in only 1 of 26 (4%) children of healthy mothers (p < 0.001). In contrast to this, none of 6 children of multigravidae with PE shared 2 paternal antigens with the mother. An increased homozygosity at the HLA-B locus was also seen in the children of primigravidae with PE (40 vs. 4%, p = 0.01).

Adult↗
PubMed1990

Pretreatment serum levels of CA-125, carcinoembryonic antigen, tissue polypeptide antigen, and placental alkaline phosphatase, in patients with ovarian carcinoma, borderline tumors, or benign adnexal masses: relevance for differential diagnosis.

Pretreatment serum levels of the antigens CA-125, tissue polypeptide Antigen (TPA), carcinoembryonic antigen (CEA), and placental alkaline phosphatase (PLAP) were determined in samples from 295 women with adnexal masses. At laparotomy 48% of patients had epithelial ovarian carcinoma, 9% had tumors of low malignant potential, and 8% suffered from malignancies of other kinds. The sensitivity of CA-125 with 35 U/ml as the cutoff was 88% in women with ovarian carcinoma, but 74% among those with limited disease and 58% in borderline malignancy. Only 6 of 17 mucinous ovarian carcinomas were detected. Specificity was 83%. CEA was elevated above 5.0 micrograms/liter in 15 of 17 patients with mucinous ovarian cancer. TPA detected advanced stages of malignancy, but the sensitivity was low, 53%, in cases with limited disease. PLAP was elevated in 46% of ovarian carcinoma patients. For detecting malignancy overall, the use of a parallel combination of the CA-125 and CEA assays was more sensitive than use of CA-125 as a single marker. This test combination may be of value in the diagnosis of adnexal masses. The predictive value of a positive result was 90%, and that of a negative result, 76%.

Adnexal Diseases↗
PubMed1990

Pretreatment serum levels of CA-125, carcinoembryonic antigen, tissue polypeptide antigen, and placental alkaline phosphatase in patients with ovarian carcinoma: influence of histological type, grade of differentiation, and clinical stage of disease.

Pretreatment serum levels of the tumor-associated antigens CA-125, tissue polypeptide antigen (TPA), carcinoembryonic antigen (CEA), and placental alkaline phosphatase (PLAP) were analyzed in 142 patients with epithelial ovarian carcinoma, and related to clinical and histopathological parameters. In a linear multiple regression model CA-125 serum levels were profoundly influenced by the type of tumor, i.e., mucinous or nonmucinous. Clinical stage also had significant impact, whereas grade of differentiation did not, when the other two factors were taken into account. CEA levels were also dependent mainly on histological type. Mucinous tumor cases had high levels. Only clinical stage or tumor burden had a significant impact on TPA levels. PLAP levels were significantly influenced by histological type of tumor and by grade of differentiation but not by clinical stage. The dependence of CA-125 levels upon clinical stage was evident only in nonmucinous tumors. Furthermore, size of the primary tumor was not important for the CA-125 value, in contrast to FIGO stage. Thus CA-125 is primarily a sensitive indicator of disseminated disease in ovarian carcinoma patients. On the basis of the CA-125 level it was possible to predict the extent of disease with an overall accuracy of 55%. If TPA and CEA levels were also considered, the predictive accuracy was 63%.

Alkaline Phosphatase↗
PubMed1990

Premature rupture of the membranes--intervention or not.

Premature rupture of the membranes (PROM) in otherwise uncomplicated full-term single pregnancies was studied in a prospective randomized study. Ninety-three women were randomized to either induction with oxytocin infusion (n = 43) or expectant management (n = 50). Twenty-four and 26 respectively were nulliparas. In the induction group, all but 3 were delivered within 24 h from PROM. There were 3 vacuum extractions (VE), all in nulliparous women. No cesarean section (CS) was performed. In the expectancy group, 23 of 50 were delivered within 24 h. There were 5 VE and 3 CS in nulliparas and 1 VE and 1 CS in paras. The instrumental actions were mainly due to arrest of 1st or 2nd stage labor. The only clinical infections occurred in nulliparas in the expectancy group. Our conclusion is that parous women with PROM can be treated by either induction or expectancy while in nulliparas, induction after some hours' expectation seems preferable.

Adult↗
PubMed1986

Serum levels of pregnancy-specific beta 1-glycoprotein (SP1) and human chorionic gonadotropin (beta-hCG) in women using an intrauterine device.

Forty-two women using intrauterine contraceptive devices volunteered in a study in which blood samples were drawn in late luteal phase 1-3 times during 73 menstrual cycles. In all 129 blood samples were collected. Pregnancy-specific beta 1-glycoprotein (SP1) and human chorionic gonadotropin (beta-hC) were measured by radioimmunoassays. SP1 was measurable in 5/129 samples and beta-hCG in 2/123 samples. Both SP1 and beta-hCG were measurable in 2 samples. All women in the study had regular menstrual periods. It is concluded that an early implantation and subsequent abortion in connection with a "normal" menstruation could occur but in a frequency that is much lower than in women using no contraception.

Abortion, Spontaneous↗
PubMed1984

Pregnancy-specific beta 1-glycoprotein, SP1, in maternal serum during uncomplicated single pregnancies.

Pregnancy-specific beta 1-glycoprotein (SP1) levels in uncomplicated single pregnancies were measured by radioimmunoassay from the time of ovulation until the 8th week of pregnancy in 129 blood samples from 78 women. SP1 was detectable in all samples examined from 34 days after the last menstrual period (LMP), and thereafter the SP1 level increased rapidly with time and 38 to 40 days after LMP the geometric mean SP1 concentration was 90 micrograms/l. From pregnancy weeks 8 to 41, SP1 levels were measured by nephelometry in 1255 blood samples from 1255 women. A 95% reference range was established using logarithmic transformation. There was a steady increase in the SP1 concentration until the last month of pregnancy, in which a tendency to level off was seen, the geometric mean levels ranging from 149 to 170 mg/l. The day-to-day variation was studied during 5 consecutive days in 10 women. No significant variation was found. The diurnal variation was studied in blood samples taken every 4th hour during a 24-hour period form 10 women. A significant decrease was found at midnight and at 4 a.m. The elimination rate of SP1 from serum was studied in 10 women following labor. Elimination was non-linear and the time taken for SP1 to decrease to 50% ranged from 24 to 50 hours. No correlation was found between the concentration of SP1 and parity, maternal age, or the sex of the infant. The SP1 concentration was significantly lower in heavier women (greater than 70 kg) than in lighter women (less than or equal to 70 kg).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1984

Pregnancy-specific beta 1-glycoprotein (SP1) levels measured by nephelometry in serum from women with vaginal bleeding in the first half of pregnancy.

Pregnancy-specific beta 1-glycoprotein (SP1) levels were measured by nephelometry in sera from 107 women admitted to hospital because of vaginal bleeding in weeks 8 to 20 of pregnancy. The SP1 results were compared with those in single samples from 655 women and serial samples from 9 women with uncomplicated single pregnancies in the same period. The possibility of predicting the outcome of a pregnancy complicated by vaginal bleeding was calculated on the basis of the SP1 level on admission to hospital. In 65% a normal SP1 value predicted continuation of pregnancy, whereas a low SP1 value invariably predicted spontaneous abortion.

Abortion, Spontaneous↗
PubMed1983

Serum levels of pregnancy-specific beta 1-glycoprotein (SP1) in women with pregnancies at risk.

Pregnancy-specific beta 1-glycoprotein (SP1) concentrations were measured by nephelometry in 133 serum samples from 74 women in their last trimester of pregnancy. All women carried one child but their pregnancies were complicated by pre-eclampsia, essential hypertension, diabetes mellitus or rhesus isoimmunization. Most of the women with pre-eclampsia or essential hypertension who gave birth to infants of normal weight had SP1 values evenly distributed within the reference range. Women with insulin-dependent diabetes mellitus who gave birth to infants to normal birth weight or large-for-date infants had SP1 levels well within the reference range and even showed a tendency to overrepresentation above the geometric mean. Women with rhesus isoimmunization all delivered infants of normal birth weight. Their SP1 values were near or above the geometric mean of the reference range. No special pattern of SP1 levels was observed in relation to the severity of the immunization.

Antibody Formation↗
PubMed1983

Pregnancy-specific beta 1-glycoprotein (SP1) in serum from women with pregnancies complicated by intrauterine growth retardation.

Serum concentrations of pregnancy-specific beta 1-glycoprotein (SP1) were measured by nephelometry in 37 women with single pregnancies complicated by intrauterine growth retardation (IUGR). Sixty-seven blood samples were examined for their contents of SP1 in pregnancy weeks 29 to 40. The SP1 values were compared with those obtained in a cross-sectional study of 323 women and a serial study of 21 women (210 samples) with uncomplicated single pregnancies. It was found that a serum SP1 value below 80 mg/l in a single blood sample drawn in pregnancy weeks 32 to 34 had a predictive value of 50% for IUGR and a value above or at 80 mg/l had a value of 93% for predicting a normal infant birth weight. Serial samples from individual women with uncomplicated single pregnancies showed an average increase in the SP1 concentration of 49% from pregnancy weeks 30 to 36. In serial samples from six women with IUGR infants there was no such increase, or a decrease occurred. It is concluded that SP1 measurements in maternal serum are valuable for the detection and monitoring of pregnancies complicated by IUGR.

Female↗
PubMed1981

Nonimmune complexes of pregnancy-specific beta 1-glycoprotein explain its heterogeneity.

Nonimmune complexes of pregnancy-specific beta 1-glycoprotein (SP1) explain its heterogeneity. Two proteins reacting with antisera specific to pregnancy-specific beta 1-glycoprotein (SP1) have previously been detected in serum from pregnant women by use of crossed immunoelectrophoresis (CIE). The major SP1-reactive protein, SP1 beta, has a molecular weight of about 90,000 and the minor, antigenically deficient protein, SP1 alpha, about 200,000. In this study, gel filtration of serum on Ultrogel AcA 34 and Sephacryl S-300 has revealed that classical radioimmunoassay (RIA) techniques of two types only measure SP1 beta. With RIAs specially designed to detect complexed SP1 two higher molecular weight, SP1-containing complexes could be identified. CIE of serum or fractions from gel filtrations revealed a loss of the anodal part of the SP1 precipitate. However, when 4% polyethylene glycol (PEG) was incorporated in the anti-SP1-containing gel an antigenically deficient precipitate developed in the alpha-region. Incorporation of antialbumin in an intermediate gel in CIE reduced the anodal loss of the SP1 precipitate in anti-SP1-containing gels without PEG which resulted in a homogeneous peak. In addition, in anti-SP1-containing gels with PEG the anodal precipitate was reduced. This SP1-albumin complex fulfills all criteria for the previously described SP1 alpha. For measuring low levels of SP1 RIAs can be used. For higher values nephelometry is preferable. Although the amount of complexed SP1 is small in comparison with the amount of native SP1 methods employing electrophoresis are not recommended. In such tests SP1 complexed to fast-moving proteins like albumin might influence the results.

Antigen-Antibody Complex↗