The pharmacology of diphenylalkyl derivatives. I. Comparative studies of coronary dilator diphenylalkylamine derivatives.
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Biomedical subjects
Publications and source records attributed to L Tardos.
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GYKI-32 887 reveals an antihypertensive action, similar to that of the known ergoline derivatives, in conscious SH-rats, in anesthetized normotensive rats, and in cats. It exerts its action first of all by stimulation of the central DA-receptors and by this it reduces the sympathetic activity. The hypotensive effect cannot be detected after icv administration, but both the hypotension and bradycardia can be antagonized by sulpiride administered either icv or iv.