PubMed Health⌕ Search

Biomedical subjects

L Taussig

Publications and source records attributed to L Taussig.

8 recordsLinked to original sources
PubMed1992

A scoring system for lung function tests in infants.

Measurements of thoracic gas volume (TGV), airway resistance (Raw), and airway conductance (Gaw) were calculated in a group of 42 normal infants using a whole-body plethysmograph. Maximum expiratory flow at functional residual capacity was measured in a separate group of 108 normal infants. Using data obtained from these infants the following regression equations were calculated: Gaw (L.s-1.cmH2O) = -0.0475 + 0.00164 x length (cm) square root of TGV (mL1/2) = -3.22 + 0.263 x length (cm) VmaxFRC (mL.s-1) = -173 + 5.2 x length (cm). The standard errors of prediction are a measure of the scatter of individual results from the normal population about the true regression line. They were used to define limits of the normal ranges for these tests of lung function, and to develop a scoring system. This approach is preferable to expressing results as percent predicted, which gives no indication of how likely a measurement is to be within normal limits.

Age Factors↗
PubMed1991

Relationship of total serum IgE levels in cord and 9-month sera of infants.

To characterize IgE levels at birth and changes in those levels during the first year of life and to identify factors that might influence IgE levels in infancy, we measured IgE levels in 1074 umbilical cord sera and in 697 sera obtained at 9 months of age in a healthy population of infants enrolled at birth into the Children's Respiratory Study in Tucson, Arizona, U.S.A. Serum IgE levels at birth and 9 months were log normally distributed with geometric means of 0.09 and 3.87 IU/ml, respectively. Cord serum IgE levels were unaffected by maternal smoking. Levels varied according to month of birth with a nadir in September. Cord and 9-month serum IgE levels were higher in boys than in girls, Hispanics compared with Anglos, and infants who developed eczema compared with those who did not, but the mean increases in log IgE from birth to 9 months were not significantly affected by these factors. A significant correlation between IgE levels at cord and 9 months was observed (r = 0.44; P less than 0.0001). Also, mean log IgE levels at 9 months in infants grouped according to cord serum IgE levels maintained the same rank order of mean values as the cord groups. These data indicate that 9-month IgE levels are influenced by cord serum IgE levels and that the main influence of gender, ethnicity and susceptibility to eczema on IgE levels occurs before birth.

Age Factors↗
PubMed1976

Influence of bronchomotor tone on regional ventilation distribution at residual volume.

We studied the topographical distribution of 133Xe boluses inhaled slowly from RV, as well as the distribution of regional volumes at RV (RVr) in seven seated normal subjects before and after aerosolized isoprenaline (ISO) and after aerosolized methacholine hydrochloride (Mech). After Mech the ratio of inhaled 133Xe in the upper lung regions to that in lower lung regions (U/L) decreased from 3.21 +/- .33 (mean +/- 1 SE) to 1.27 +/- 0.12 (P less than 0.001) and returned to 3.89 +/- 0.55 after Iso. Iso alone increased U/L from 3.23 +/- 0.47 to 5.49 +/- 0.85 (P less than 0.025). The height of phase IV in expired 133Xe vs. volume plots correlated with U/L, being greater after Iso and smaller after Mech in each subject. The difference in RVr between upper and lower lung regions decreased after Mech in four out of five subjects from 0.22 TLC to 0.11 TLC. Iso alone did not change the gradient of RVr. The results are consistent with the concept that increased bronchomotor tone widens the range of critical opening and closing pressures with a more patchy and extensive distribution of airway closure.

Adult↗