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Biomedical subjects

L Teppo

Publications and source records attributed to L Teppo.

At least 109 records · Page 6Linked to original sources
PubMed1985

Age dependence of the west/east gradient in cardiovascular mortality of Finnish males.

A cohort of 4 475 Finnish men was followed up during 1964-80 in order to study regional differences in mortality from cardiovascular diseases, especially ischaemic heart disease (IHD). The west/east gradient in cardiovascular mortality recorded in several previous studies was greatly age-dependent. The excess eastern risk was a feature of younger age groups; with increasing age the risk pattern was reversed. The risk factors in IHD in eastern Finland have an element which somehow accelerates the process of this disease.

Adult↗
PubMed1985

Multiple cancer--an epidemiologic exercise in Finland.

The material of the Finnish Cancer Registry from 1953-79 (279,745 cancer patients, 774,518 person-yr at risk) was analyzed for the occurrence of multiple cancer. There were 5,871 new primary cancers in the series (excluding the first 12 mo from diagnosis of the first cancer). A positive association between cancers with similar etiology could be demonstrated, e.g., between cancers of the lip, larynx, and lung (smoking) and between cancers of the breast and endometrium (hormones, reproductive history). Clustering of different risk factors resulted, e.g., in an excess risk of colon cancer among female breast cancer patients (risk factors in both cancers are prevalent particularly in higher-social classes). Differences in the distribution of the risk factors resulted in risk deficits, e.g., low relative risk of lung cancer among male colon cancer patients (the prevalence of smoking was highest in the lower-social classes and the prevalence of risk factors in colon cancer was highest in the higher-social classes). The risk of leukemia was increased among patients with cancers of the breast, endometrium, and thyroid (possibly due to irradiation). There was a high relative risk of salivary gland cancer among patients with skin cancer other than melanoma or basal cell carcinoma in both sexes. The relative risk of a new primary cancer decreased with increasing age at diagnosis of the first cancer. The length of follow-up was positively associated with the relative risk of many cancers, although this finding was not as consistent as that with age.

Adolescent↗
PubMed1984

Cancer incidence by living area, social class and occupation.

The variation in the incidence of cancer between geographic areas and socio-economic classes is outlined. In many instances the differences in the incidence can be attributed to differences in life-style factors such as smoking, diet, sexual habits, and the reproductive history of women. The role of smoking as an explanation of the variation in the risk of lung cancer between occupational groups is emphasized.

Age Factors↗
PubMed1983

Occupation and smoking as risk determinants of lung cancer.

The standardized incidence ratio (SIR) of lung cancer was determined for different occupational groups in Finland. The data on all cases of lung cancer diagnosed in Finland in age groups of 35-69 years in 1971-1975 were supplemented by information on occupation from the 1970 census (Central Statistical Office). The expected numbers of cases were based on the sex, age and occupation-specific numbers of person-years computed in the Central Statistical Office, and sex- and age-specific incidence rates of lung cancer among the economically active population (as defined 1 January 1971). Compared with the risk of the total economically active population, the relative risk of those not active (SIR) was 1.69 for men and 0.86 for women. Lower than expected relative risks were encountered among highly educated and white-collar male workers (religious, legal, pedagogical, medical, technical and administrative work), in sales work, transport service work and among farmers. High SIRs were found in mining and quarrying, forestry, woodworking (joiners), construction, painting and among unskilled workers. Among women the numbers of cases were small and only one significant SIR was obtained; the risk was lower than expected in farming. Data on the smoking habits of males in different main occupational categories in Finland show that variation between different occupational groups in the prevalence of smoking closely corresponds to that in the SIR for lung cancer (R = 0.96).

Adolescent↗
PubMed1983

[Lung cancer in Finland].

Lung cancer incidence in Finland ranked first in the late fifties. In the seventies, 2,000 new cases of lung cancer in males were registered annually, i.e. more more than a third of all newly-registered cases of cancer. At present lung cancer ranks tenth in females. About 300 new cases (nearly 5% of all primary malignancies) are reported every year. Every effort must be made to comprehend the etiology of lung cancer and to develop methods of its prevention.

Adenocarcinoma↗
PubMed1982

Risk indicators of breast and cervical cancer on ecologic and individual levels.

Ecologic and individual risk indicators were derived from the population censuses of Finland Cancer Registry. The years covered in the study were 1955-1974 for the ecologic analysis and 1971-1975 for the analysis on individuals. The incidence of both diseases was high in an urban environment with high standard of living. The individuals with high risk of breast cancer were of high socioeconomic status and were well educated, whereas cervical cancer was common among women of low socioeconomic status and with less education. Conceptually similar indicators used on both the ecologic and individual levels characterize different aspects of risk; for example, a woman with a low standard of living in a well-to-do environment has a high risk of cervical cancer.

Adolescent↗
PubMed1981

Occupations with low risk of lip cancer show high risk of skin cancer of the head.

The standardized morbidity ratios (SMR) of lip and non-melanomatous skin cancer (basal-cell carcinoma excluded) of the head and neck in males were determined for different occupational groups in Finland. The data on all cases of these types of cancer diagnosed in Finland in the age group 35-69 years in 1971-75 were supplemented by information on occupations from the 1970 census (Central Statistical Office of Finland). The expected numbers of cases were based on the age and occupation-specific numbers of person-years computed by the Central Statistical Office, and the age-specific incidence rates of lip and skin cancers among the economically active population. The highest SMR of lip cancer among all the occupational groups was found in agriculture, forestry and fishing (1.64). In contrast, the SMR of skin cancer was not higher than expected in occupations related to agriculture and forestry. Significantly lower than expected risks of lip cancer were observed among highly educated white-collar workers, among whom the risk of contracting skin cancer was the highest (technical, scientific, humanistic and artistic work, SMR 1.78). The morbidity of both lip and skin cancers varies considerably by occupation, and the risks seem to be, at least in part, inversely related. Thus, it is probable that there are also differences in the risk factors, contrary to several earlier suggestions. The nature of these factors are discussed.

Adult↗
PubMed1981

Incidence of different morphological types of thyroid cancer in the Nordic countries.

In order to determine the incidence of different morphological types of thyroid cancer in the Nordic countries, all cases of thyroid cancer reported to the national cancer registries of Finland, Iceland, Norway and Sweden over periods ranging from 1 to 14 years were re-examined (a total of 706 cases) by one or two pathologists from each country. The age-adjusted incidence rate for Iceland was clearly higher than those for the other Nordic countries. The rate for Finland was the lowest, and a five-fold difference was seen between Iceland and Finland. The differences in the incidence rates applied to all age groups and to both sexes. The differences also concerned all histological types and were more pronounced for papillary and medullary carcinomas. In papillary carcinoma, an almost 10-fold difference was found between Finland and Iceland. The causes of the differences are not known. There has been and probably still is some endemic goitre in Finland, Norway and Sweden, but no endemic goitre occurs in Iceland. Thus, no positive association was found between the presence of endemic goitre and the risk of follicular carcinoma. There was a marked negative association between endemic goitre and the risk of papillary carcinoma.

Adenocarcinoma↗
PubMed1980

Is upper lip cancer "true" lip cancer?

A description is given of the occurrence of upper and lower lip cancers in Finland in the period 1953-1974 with the aim of reaching conclusions on the possible differences in the etiological factors involved. Substantial differences with respect to various epidemiological parameters, such as incidence rates, trends in the incidence with time, male/female ratios of the incidence rates, age-incidence curves, urban/rural ratios of the incidence rates, and geographical distribution, were demonstrated between upper and lower lip cancers. On the other hand, similarities in the occurrence of upp]er lip cancer and non-melanomatous skin cancer of the head and neck could be observed. It was concluded that in terms of etiology upper lip cancer could be regarded as a separate entity and different from "true" lip cancer of the lower lip. The role of recurrent herpetic infections of the lips is also discussed.

Adult↗