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L Tomasević

Publications and source records attributed to L Tomasević.

4 recordsLinked to original sources
PubMed1990

Circulating autoantibodies in multiple sclerosis.

By using indirect immunofluorescence method, we analyzed the presence of antinuclear, anticardiac, microsomal, parietal-cell, smooth-muscle and mitochondrial antibodies in sera of 33 patients with definite multiple sclerosis (MS), without clinical evidence of associated autoimmune disorder, and 14 patients with other neurological disorders (OND). In MS patients, the prevalence of both organ-specific and non-organ-specific antibodies was significantly higher (p less than 0.05) than in OND patients. In both groups, the titers of circulating antibodies were low. The presence of low levels of autoantibodies in sera of MS patients might be the result of immunodysregulation in MS.

Adult↗
PubMedDate not supplied

[Simultaneous recording of spirometric parameters and total respiratory resistance on the Astograph in nonspecific bronchial provocation tests using methacholine].

Parallel study results of spirometric parameters (S.P.) FEV1, FEF50, FEF25 and total respiratory resistance (Rrs) measured by Astograph in nonspecific metacholine bronchoprovocation test were analyzed in 378 patients suspected of bronchial asthma. The patients were divided into 7 groups based on Astograph and S.P. instances criteria. Of 92 patients with positive test results, 91% met the set Astograph criterium; 72% met all three S.P. criteria, 1% one criterium and 12% failed to meet any of the S.P. criteria. It was noted that the patients met more the FEF50 and FEF25 criteria (87%) than FEV1 (73%). Also, there was no significant increase in respiratory resistance for those with a predominant reaction in small airways (9%). This fact points to the need of introducing appropriate complementary Astograph methods.

Adult↗
PubMedDate not supplied

[Simultaneous recording of nonspecific bronchial response using continuous measurement of total respiratory resistance and oxygen saturation of arterial blood].

In 78 patients with bronchial asthma symptoms undergoing nonspecific bronchial response test with bronchoprovocation inhalation of progressively increased methacholine concentrations, total respiratory resistance (Rrs) and oxygen saturation (SaO2) of arterial blood were continually measured. An average Rrs increase was 153% when compared to the initial values and it correlated with SaO2 decrease (5.5% of the initial values). In 45 patients along with continual Rrs and SaO2 measurements, bronchoprovocation test and spirogram flow-volume curve were periodically done. Ten of these patients had no significant Rrs or FEV1 changes, but there was a considerable drop in FEF50, FEF25 and SaO2. These results, associated with dyspnea and physical pulmonary findings in the course of BPT, as well as history of patients with similar difficulties in every-day life and in work environment, point to the need of expanding diagnostic criteria for positive BPT and for patients who did not have Rrs increased double the initial values nor sufficient FEV1 20% drop. Spirometry and oximetry as complementary methods, increase Astograph sensitivity to methacholine test. Oximetry has an advantage of enabling continual SaO2 monitoring and increased patient's safety during the BPT.

Airway Resistance↗