[The degree of mineralization of bone tissue in chronic uremia compared with radiological, biochemical and clinical findings].
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Biomedical subjects
L Tougaard
Publications and source records attributed to L Tougaard.
[Phosphorus/hydroxyprolin-ratio in bone tissue. A method of estimating the degree of mineralization in bone tissue].
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The degree of mineralization in normal bone tissue estimated as the phosphorus to hydroxyproline ratio.
The degree of mineralization can be evaluated from the phosphorus to hydroxyproline ratio in bone biopsies. A small but significant rise in the ratio with increasing age was observed in 137 persons without bone diseases, aged from 20 to 89 years. No significant difference between men and women was found with regard to the phosphorus to hydroxyproline ratio. The study indicates that with increasing age, in addition to senile osteopenia, there is also a change in the form of an increase in the degree of mineralization.
Adult↗
The degree of bone mineralization in chronic renal failure estimated from phosphorus/hydroxyproline ratio in bone biopsies.
The degree of bone mineralization is the proportion between the contents of mineral and collagen in bone. As phosphorus (P) and hydroxyproline (Hypro) constitute a constant fraction of bone mineral and collagen, respectively, the P/Hypro ratio in bone tissue provides an estimate of the degree of mineralization. The P/Hydro ratio has been studied in bone biopsies from 42 patients with severe chronic renal failure. A few of them had a subnormal P/Hypro ratio and these patients corresponded to the diagnosis of classical osteomalacia or probably hyperparathyroidism. However, the mean bone P/Hypro ratio was significantly higher than normal, indicating a general tendency towards a higher degree of bone mineralization in patients with chronic renal failure.
Adult↗