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Biomedical subjects

L Townsend

Publications and source records attributed to L Townsend.

At least 19 recordsLinked to original sources
PubMed1986

Electrophoresis and immunoblot of cerebrospinal fluid proteins in spasmodic torticollis.

Protein patterns of cerebrospinal fluid (CSF) from patients with spasmodic torticollis (ST) were investigated to determine whether abnormalities previously reported could be detected and further identified. CSF was collected from 12 patients with ST and 6 normal controls. The CSF proteins were analyzed using sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis and silver staining. In 11 of the 12 patients with ST, a CSF protein pattern was observed which differed from that in the controls. The identity of the abnormal proteins was ascertained by blotting and immunostaining with specific antisera to IgG and ceruloplasmin (Cp). CSF from 2 of 12 patients had distinct bands staining for IgG and 7 had abnormal immunostaining for Cp.

Adult↗
PubMed1984

Geographic tongue. Report of a case showing significant reduction in lingual tactile sensitivity.

A case of a 25-year-old white adult female with geographic tongue is reported. A decrease in lingual tactile sensitivity was indicated to exist as measured through mechanical vibration. This decreased lingual sensitivity remained constant over a 10-week interval, even though the patient developed an overall healthier general outlook during this period. The overt symptoms accompanying this condition also changed from day to day, but appeared to have little or no effect on the overall decreased lingual tactile sensitivity.

Adult↗
PubMed1982

Kinetics of [14C-5] 8-methoxypsoralen distribution in rabbits.

Distribution, kinetics and localization of 8-methoxypsoralen (8-MOP) was determined in rabbits over 24 h following i.v. administration of [14C-5] labeled and carrier 8-MOP at respective concentration of 50 muCi and 5 mg/kg. Peak levels were reached by kidneys at 1 h (18,500 ng/g) at 2 h by liver (2,470 ng/g) and at 8 h by bile (64,000 ng/g). Muscles, lymphatic tissues and brain showed low drug uptake (800 ng/g). Endocrine organs also had low drug concentration. In gastrointestinal tract the maximum level of 8-MOP was 1,500 mg/g at 1 h in jejunum. Plasma 8-MOP concentration was 3,700 ng/ml at 5 min post injection with 100 ng/ml still detectable at 24 h. Urine label concentration peaked at 1 h (4 x 10(5) cpm/ml) and was 2 x 10(2) cpm/ml at 24 h. The intact skin concentration was at the maximum during the first 30 min (1,958 ng/g) declining progressively thereafter to 155 ng/g at 24 h. The UVA irradiated skin (320-380 nm at the rate of 14.2 mW/cm2 x s-1 for 1 h) had a higher 8-MOP concentration (2,834 ng/g at 1 h and 280 ng/g at 24 h).

Animals↗
PubMed1978

Paediatric follow up of pregnancies complicated by subnormal oestriol excretion. Interim report.

In 92 pregnant women with low urinary oestriol excretion after 30 weeks' gestation, there was a higher incidence of fetal distress, premature delivery and induced labour, while resuscitation of the infant at birth was required more often than in controls. The birth weights, head circumference, and body lengths of the infants were significantly lower than those of the controls. In the 26 cases where maternal oestriol levels were persistently low, three were associated with placental sulphatase deficiency, and three infants died postnatally. Four infants had evidence of neurological defects on follow up, as did four infants in the control group. The low head circumferences, weight, and length were still present at two years of age. It is concluded that, although low oestriol excretion during pregnancy is associated with increased risk to the fetus, it is not associated per se with permanent neurological damage, provided the infant is born alive, and is congenitally normal. However, many infants remain smaller than average, at least for the first years of life.

Birth Weight↗
PubMed1977

Maternal mortality in Australia 1964-72.

Statistics covering deaths directly due to pregnancy in the Commonwealth of Australia have been available since the turn of the century. However, those for deaths associated with pregnancy have not. Over the past two decades each State in the Commonwealth has set up Maternal Mortality Committees to collect confidential information on each maternal death, both direct (where the death is directly attributable to pregnancy or childbirth) and associated (where the death is associated with but not directly due to pregnancy or childbirth). New South Wales had set up the first such Committee in the 1930's, and this has since been followed by the other States. Most of the States have published reports from time to time but, owing to the small numbers involved, these reports have been limited in the conclusions that could be made. Confidential information on each maternal death is obtained and is considered by the State Maternal Mortality Committee. The cause of death is confirmed and classified. A necropsy is usually performed in each instance, the pathologist travelling to the town where the death has occurred, if requested.

Abortion, Induced↗
PubMed1976

The induction of ovulation.

A treatment plan utilizing placebo, cyclical steroid therapy, clomiphene citrate, and human pituitary gonadotropin is outlined for the induction of ovulation in carefully selected potentially fertile women. Such a plan minimizes any risk with the potentially hazardous ovulatory stimulants. A total of 220 patients with secondary amenorrhea were studied and an etiologic basis for the condition was found in 98 (45 per cent). Of the 220, 190 were found suitable for the induction of ovulation, and together with 145 patients with oligomenorrhea and 17 patients with anovulation, entered the treatment plan. Ovulation was successfully induced in 351 of the 352 (99.5 per cent) and pregnancy in 218 (61.9 per cent). The success rates for the agents in the various conditions are presented and discussed.

Amenorrhea↗
PubMed1975

Maternal deaths in Australia compared with England and Wales from 1967 to 1969.

A comparison of the main causes of maternal death in Australia and in England and Wales over the same three-year period from 1967 to 1969 was undertaken, based on the trienneal reports from the two countires. In this triennium the maternal mortality rates (maternal deaths due to pregnancy and childbirth and not including associated maternal deaths) of the two countries were very similar, that of Australia being 0.23 per 1,000 and that of England and Wales being 0.21 per 1,000. These figures include death due to abortion, and both show an improvement from the previous triennium. Comparison of the figures still reveals higher death rates from haemorrhage, pulmonary embolism and preeclampsia in Australia than in England and Wales, but this is largely balanced by the higher death rate from abortion in England and Wales. In 1972 Neil and Townsend compared the first report on maternal deaths in the Commonwealth of Australia with the fifth report on maternal deaths in England and Wales, covering the triennium 1964 to 1966. The purpose of this article is to compare the reports on the triennium 1967 to 1969 (Beischer et alii, 1972); Report on Confidential Enquiries into Maternal Deaths in England and Wales, 1967-1969) and to comment on the improvements which have occurred in this triennium.

Abortion, Illegal↗