Corticosteroid complications in respiratory disease.
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Biomedical subjects
Publications and source records attributed to L Tuft.
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Excellent clinical results were obtained in 85 patients with chronic asthma who took corticosteroids (mostly triamcinolone) on a long-term basis for periods varying from one to 26 years. There was a minimum of side-effects, none serious; the most discomforting were ecchymosis and a tendency to easy bruising. The results of this and previous studies have convinced the author that corticosteroids, if judiciously used, are the most valuable adjunct we have in the treatment of acute and chronic asthma.
In 18 ragweed hay fever patients who received injections of alum-precipitated pyridine (Allpyral) ragweed extracts in maintenance doses of between 6000 and 8000 P.N.U. at intervals of between two and four months over a two-year period, the prolonged interval did not seem to influence either the clinical response or the tendency to reaction, or result in significant change in immunological tolerance as determined by antibody studies, which included fluorescent antibody assays, as well as hemagglutination and RAST technics.
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Hyposensitization therapy with APP extracts was found to be effective in 80% of 185 patients allergic to animals (96 to cats, 84 to dogs and 5 to horses) with a minimum of reactions (2.5 local and 0.2% constitutional). Lower respiratory symptoms were the most common complaints, followed by nasal, ocular and respiratory, singly or in combination.
A rare instance of contact-type urticaria resulting from an acquired sensitization to cephalosporin compounds in a chemist is reported. Patch tests elicited an immediate urticarial rather than a delayed contact-type response. Similar control tests to other antibiotics gave negative results. Although the patient's primary complaint was urticaria, prolonged or excessive contact with the cephalosporins caused coryza and dyspnea. Following transfer to another laboratory where the patient worked with other chemicals, there was no recurrence of symptoms.
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