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Biomedical subjects

L Turner-Stokes

Publications and source records attributed to L Turner-Stokes.

44 records · Page 3Linked to original sources
PubMed1989

Does rheumatoid factor protect lupus patients from the development of nephritis?

It has been suggested again recently that the presence of rheumatoid factor (RF) in the serum of patients with systemic lupus erythematosus (SLE) protects them from the development of nephritis. In this study the RF is measured by standard latex test and by radioimmunoassay to detect IgM, IgA, and IgG isotypes, in patients with SLE with (26 patients) and without (25 patients) renal involvement, and in a control group of 21 patients with idiopathic renal disease. In addition, patients with SLE and nephritis were tested during active and inactive phases of their disease. No significant protective effect was observed from the presence of RF.

Humans↗
PubMed1988

In vitro response to influenza immunisation by peripheral blood mononuclear cells from patients with systemic lupus erythematosus and other autoimmune diseases.

Reduced in vitro anti-influenza antibody response by peripheral blood mononuclear cells (PBMs) after vaccination was confirmed in a group of 28 patients with systemic lupus erythematosus (SLE), and also in 16 patients with some other autoimmune syndromes. This group of patients with SLE had higher serum anti-DNA binding, but there was no evidence of increased autoantibody production after vaccination, nor any clinical or laboratory evidence of flares in disease activity that are sometimes seen to follow intercurrent infection. Although a reduced in vitro antibody response may, to some extent, reflect redistribution of antibody producing cells, there appears to be more generalised impairment of the immune response in these patients, which cannot be accounted for by steroid/immunosuppressive therapy.

Adult↗
PubMedDate not supplied

Charter for disabled people using hospitals: a completed access audit cycle.

This completed audit cycle assessed access for disabled people to a district general hospital, in relation to standards laid down in the Royal College of Physicians Charter for Disabled People using Hospitals. The project was effective in demonstrating problems and implementing change to overcome them. It was also useful in raising disability awareness in the young investigators, who easily recognised the shortcomings in facilities for disabled people, and is proposed as a possible model for inclusion in medical undergraduate training programmes to raise disability awareness amongst a new generation of doctors.

Persons with Disabilities↗
PubMedDate not supplied

In vitro lymph node and peripheral blood lymphocyte responses to influenza immunization in patients with systemic lupus erythematosus.

Following influenza immunization, in vitro anti-influenza antibody production by peripheral blood lymphocytes (PBM) taken from some patients with systemic lupus erythematosus is shown to be impaired despite apparently normal serum antibody responses. One explanation for this finding could be the sequestration of antibody-producing cells in the lymphoid tissue. In this study, antibody production in vitro by lymphocytes from peripheral blood and lymph nodes was measured in parallel following influenza immunization of SLE patients and normal controls. Antibody production by lymph node cells was confirmed in the presence of an impaired PBM antibody response, suggesting redistribution of antibody-producing cells to the lymphoid tissue. This finding was not however, confined to SLE patients, and the relatively low serum antibody response in these individuals suggests a more generalised impairment of the immune response.

Antibody Formation↗
PubMedDate not supplied

Clinical differential diagnosis of shoulder pain.

Shoulder pain may arise from a number of different structures, as well as from different pathologies within the shoulder itself. This article aims to provide a guide to clinical differential diagnosis and functional assessment.

Activities of Daily Living↗