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Biomedical subjects

L U Tina

Publications and source records attributed to L U Tina.

14 recordsLinked to original sources
PubMed1988

Relationship of steroid dose to degree of posterior subcapsular cataracts in nephrotic syndrome.

Forty-five patients with nephrotic syndrome were included in our study. Of these, 30 received adrenocorticosteroid therapy and 15 did not. The ages of the patients ranged from 11 months to 27 years and the duration of steroid therapy from 2 1/2 years to 20 years. Seventeen patients (38%) showed posterior subcapsular cataract (PSC) formation and, of these, seven patients (41%) showed reversal of PSC. There was no statistical correlation between the total dose of steroids and the degree of PSC. An individual susceptibility may be an important factor in the production of PSC. None of the patients had visual acuity less than 20/30.

Adolescent↗
PubMed1984

Autoantibodies in minimal change nephrotic syndrome.

The presence of low level antibody (AAb) activity and circulating immune complexes (CIC) were studied in 17 patients with minimal change nephrotic syndrome (MCNS). Study groups include 12 MCNS without mesangial deposits (Group I) and 5 MCNS with mesangial deposits (Group II). In Group I reactivity against normal tissue antigens was demonstrated (kidney tubular microsomal antigen - 8, smooth muscle - 5, gastric cell - 5). In Group II reactivity against kidney basement membrane was demonstrated in all five patients. CIC were detected in eight (Group I - 6, Group II - 2). Dissociation of the CIC showed that they all contained antibodies with a corresponding autoantibody activity which could be removed by prior incubation with their complexed antigen. The presence of these AAb's and their formation of CIC may indicate their role in initiating a primary immunological insult to the kidney.

Adolescent↗
PubMed1981

Hyperlipidemia in children with chronic renal insufficiency.

Total serum cholesterol, phospholipids, and triglyceride levels, lipoprotein fractionation, and plasma parathormone levels were measured in a group of 31 nonnephrotic children with various levels of renal function and on hemodialysis. Group A served as controls and consisted of eight healthy children with glomerular filtration rate (GFR) greater than 110 ml/min/1.73 m2. Group B consisted of six children with GFR on 60 to 95 ml/min/1.73 m2. Group C consisted of nine children with GFR of 10 to 40 ml/min/1.73 m2, and group D consisted of eight children on maintenance hemodialysis with GFR of 0 to 5 ml/min/1.73 m2. Among the groups, there were no significant differences in total serum cholesterol and phospholipid levels. A significant (P less than 0.05) increase in triglyceride levels was observed in patient groups C and D. Lipoprotein fractionation revealed a significant increase (P less than 0.05) in the pre-beta lipoprotein levels (very low density lipoproteins) in patients in groups D with 63% of these patients demonstrating a type IV lipoprotein pattern. There were no significant differences observed in the beta lipoproteins (low-density lipoproteins). However, the alpha lipoproteins (high-density lipoproteins) decreased significantly (P less than 0.05) in patients whose GFR was below 40 ml/min/1.73 m2 (group C) as well as patients in group D. Absolute plasma parathormone levels did not significantly correlate with serum triglyceride levels did not significantly correlate with serum triglyceride levels and remained normal until after the onset of hemodialysis when they increased significantly in all patients.

Adolescent↗
PubMed1977

Reversibility of corticosteroid-associated cataracts in children with the nephrotic syndrome.

We reexamined the eyes of 39 nephrotic children to investigate further the relationship between oral corticosteroid therapy and posterior subcapsular cataract formation. The corticosteroid dosage was proportional to each patient's weight. Six children had posterior subcapsular cataracts an average of 16 months after the first examination. Nine patients had complete regression of their posterior subcapsular cataracts. We found no correlation between the age at onset of the nephrotic syndrome, the dosage or duration of corticosteroid therapy, or the renal biopsy findings and posterior subcapsular cataract formation. Cushingoid manifestations were significantly more common in the patients with posterior subcapsular cataracts. These patients may be more sensitive to the effects of corticosteroids than those who never had cataracts and those whose cataracts regressed.

Adolescent↗